DT-Web

DB03425 - 2s,4r-4-Methylglutamate


Identification
Name 2s,4r-4-Methylglutamate
Accession Number DB03425 (EXPT02986)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 162.1638
Groups experimental
Monoisotopic Weight 162.076632877
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Glutamate receptor, ionotropic kainate 2
Name Glutamate receptor, ionotropic kainate 2
Gene Name GRIK2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.2992

Predictions


Id Partner name Gene Name Score
921 Glutamate receptor 2 GRIA2 0.1026
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.09
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.09
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0766
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0758
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.069
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.069
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0687
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0634
6016 Cytochrome P450 2C19 CYP2C19 0.0105
4512 Cytochrome P450 3A4 CYP3A4 0.0085
4200 Cytochrome P450 1A2 CYP1A2 0.0074
4757 Cytochrome P450 2C9 CYP2C9 0.0072
6030 Cytochrome P450 2B6 CYP2B6 0.0064
6013 Cytochrome P450 2E1 CYP2E1 0.0062
4924 Cytochrome P450 2C8 CYP2C8 0.0057
3937 Fatty-acid amide hydrolase FAAH 0.0054
5718 Cytochrome P450 2A6 CYP2A6 0.0049
20 Prostaglandin G/H synthase 1 PTGS1 0.0024
468 Cytochrome P450 4A11 CYP4A11 0.002
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0019
6106 Cytochrome P450 2C18 CYP2C18 0.0016
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0016
1898 Cytochrome P450 1B1 CYP1B1 0.0016
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0015
776 Bile salt export pump ABCB11 0.0015
862 Multidrug resistance-associated protein 1 ABCC1 0.0014
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0014
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0014
922 Glutamate receptor 4 GRIA4 0.0014
4027 Glutamate receptor delta-1 subunit GRID1 0.0014
4018 Glutamate receptor delta-2 subunit GRID2 0.0014
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0014
1912 Excitatory amino acid transporter 1 SLC1A3 0.0014
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0014
4016 Excitatory amino acid transporter 5 SLC1A7 0.0014
4019 Excitatory amino acid transporter 4 SLC1A6 0.0014
1047 Excitatory amino acid transporter 2 SLC1A2 0.0014
664 Glutamate decarboxylase 2 GAD2 0.0014
3890 Glutamate decarboxylase 2 GAD2 0.0014
4026 Aspartyl aminopeptidase DNPEP 0.0014
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0014
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0014
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0014
925 Metabotropic glutamate receptor 4 GRM4 0.0014
926 Metabotropic glutamate receptor 7 GRM7 0.0014
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0014
927 Metabotropic glutamate receptor 8 GRM8 0.0014
4020 Glutamyl aminopeptidase ENPEP 0.0014
4017 5-oxoprolinase OPLAH 0.0013
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0013
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0013
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0013
6024 Cytochrome P450 1A1 CYP1A1 0.0013
625 Glutamate carboxypeptidase 2 FOLH1 0.0012
6107 Cytochrome P450 3A7 CYP3A7 0.0012
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0012
5 Glutaminase liver isoform, mitochondrial GLS2 0.0012
917 Glutaminase kidney isoform, mitochondrial GLS 0.0012
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0012
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0012
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0012
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0012
5261 Phosphoribosylformylglycinamidine synthase purL 0.0012
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0012
665 Phosphoserine aminotransferase PSAT1 0.0011
4652 Phosphoserine aminotransferase serC 0.0011
420 Glutamate decarboxylase 1 GAD1 0.0011
3900 Glutamate decarboxylase 1 GAD1 0.0011
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0011
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0011
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0011
4118 Cytochrome P450 3A5 CYP3A5 0.0011
923 Glutamate receptor 3 GRIA3 0.0011
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0011
916 Metabotropic glutamate receptor 1 GRM1 0.0011
1671 Excitatory amino acid transporter 3 SLC1A1 0.0011
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0011
3877 Growth-inhibiting protein 18 GIG18 0.001
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.001
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.001
914 Formimidoyltransferase-cyclodeaminase FTCD 0.001
426 Aspartate aminotransferase, mitochondrial GOT2 0.001
1588 Multidrug resistance protein 1 ABCB1 0.001
763 Tyrosine aminotransferase TAT 0.001
5493 Tyrosine aminotransferase Not Available 0.001
735 Alanine aminotransferase 1 GPT 0.001
3904 Alanine aminotransferase 2 GPT2 0.001
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.001
586 Aspartate aminotransferase, cytoplasmic GOT1 0.001
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0009
705 Glutamate receptor 1 GRIA1 0.0009
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0009
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0009
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0009
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0009
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0009
3426 Glutamine synthetase glnA 0.0009
3987 Glutamine synthetase GLUL 0.0009
33 Cystine/glutamate transporter SLC7A11 0.0009
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0009
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0009
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0007
738 Monocarboxylate transporter 1 SLC16A1 0.0007
6151 Monocarboxylate transporter 10 SLC16A10 0.0007
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