DT-Web

DB03346 - 3,5,3',5'-Tetrachloro-Biphenyl-4,4'-Diol


Identification
Name 3,5,3',5'-Tetrachloro-Biphenyl-4,4'-Diol
Accession Number DB03346 (EXPT02524)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 323.987
Groups experimental
Monoisotopic Weight 321.912190264
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Estrogen sulfotransferase
Name Estrogen sulfotransferase
Gene Name SULT1E1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.6735

Carriers


Predictions


Id Partner name Gene Name Score
492 Histamine H1 receptor HRH1 0.0448
4757 Cytochrome P450 2C9 CYP2C9 0.0414
1192 Sulfotransferase 1A1 SULT1A1 0.0396
1050 Bile salt sulfotransferase SULT2A1 0.0387
4382 Sulfotransferase family cytosolic 1B member 1 SULT1B1 0.0361
3317 Holo-[acyl-carrier-protein] synthase acpS 0.0357
4381 Holo-[acyl-carrier-protein] synthase acpS 0.0357
4380 Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 NDST1 0.0357
2390 Nonsecretory ribonuclease RNASE2 0.0306
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0273
1353 DNA topoisomerase 1 TOP1 0.0269
3552 DNA topoisomerase 1 topA 0.0269
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0259
290 Prostaglandin G/H synthase 2 PTGS2 0.0192
6258 Protein S100-A7 S100A7 0.0191
5682 Ribonuclease pancreatic RNASE1 0.0182
578 Endothelin-1 receptor EDNRA 0.0182
20 Prostaglandin G/H synthase 1 PTGS1 0.0182
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.015
1729 Solute carrier family 22 member 6 SLC22A6 0.0142
4512 Cytochrome P450 3A4 CYP3A4 0.0133
520 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0132
2306 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0132
2367 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0132
1588 Multidrug resistance protein 1 ABCB1 0.0124
6102 Arylamine N-acetyltransferase 2 NAT2 0.012
2183 Fatty acid-binding protein, adipocyte FABP4 0.0114
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0111
4924 Cytochrome P450 2C8 CYP2C8 0.0104
4200 Cytochrome P450 1A2 CYP1A2 0.0099
6024 Cytochrome P450 1A1 CYP1A1 0.0098
4119 Cytochrome P450 2D6 CYP2D6 0.0097
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0093
5718 Cytochrome P450 2A6 CYP2A6 0.0089
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0088
6013 Cytochrome P450 2E1 CYP2E1 0.0087
587 Serum albumin ALB 0.0085
594 Thyroxine-binding globulin SERPINA7 0.0082
758 Thyroid hormone receptor alpha THRA 0.008
346 Thyroid hormone receptor beta-1 THRB 0.0079
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.007
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0069
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0065
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0064
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0062
869 Estrogen receptor beta ESR2 0.006
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0055
6016 Cytochrome P450 2C19 CYP2C19 0.0054
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0052
146 Androgen receptor AR 0.0051
136 Estrogen receptor ESR1 0.0048
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0046
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0046
199 Monocarboxylate transporter 8 SLC16A2 0.0045
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0045
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
2236 Casein kinase II subunit alpha CSNK2A1 0.0045
6141 Sodium/bile acid cotransporter SLC10A1 0.0041
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.004
6228 Nuclear receptor coactivator 1 NCOA1 0.0037
6142 Solute carrier family 22 member 8 SLC22A8 0.0037
6241 Nuclear receptor coactivator 2 NCOA2 0.0036
3809 Estrogen-related receptor gamma ESRRG 0.0036
6151 Monocarboxylate transporter 10 SLC16A10 0.0035
862 Multidrug resistance-associated protein 1 ABCC1 0.0032
1898 Cytochrome P450 1B1 CYP1B1 0.003
3810 Catechol O-methyltransferase COMT 0.0027
817 DNA topoisomerase 2-alpha TOP2A 0.0026
3811 Cytochrome P450 19A1 CYP19A1 0.0021
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0018
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0016
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0016
2981 Phospholipase A2, membrane associated PLA2G2A 0.0015
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0015
275 Arachidonate 5-lipoxygenase ALOX5 0.0012
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.001
6106 Cytochrome P450 2C18 CYP2C18 0.001
1024 Solute carrier family 22 member 11 SLC22A11 0.001
2164 Multidrug resistance-associated protein 4 ABCC4 0.0009
6030 Cytochrome P450 2B6 CYP2B6 0.0008
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