DT-Web

DB03206 - 1-Deoxynojirimycin


Identification
Name 1-Deoxynojirimycin
Accession Number DB03206 (EXPT01227, EXPT01236, EXPT02374)
Type small molecule
Description An alpha-glucosidase inhibitor with antiviral action. Derivatives of deoxynojirimycin may have anti-HIV activity. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 163.1717
Groups experimental
Monoisotopic Weight 163.084457909
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity ORL-RAT LD50: > 5g/kg.
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
Name Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
Gene Name MAN1B1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.1864
Mannosyl-oligosaccharide alpha-1,2-mannosidase
Name Mannosyl-oligosaccharide alpha-1,2-mannosidase
Gene Name MSDC
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.8017
Xylose isomerase
Name Xylose isomerase
Gene Name xylA
Pharmacological action unknown
Actions Not Available
References
  • Collyer CA, Blow DM: Observations of reaction intermediates and the mechanism of aldose-ketose interconversion by D-xylose isomerase. Proc Natl Acad Sci U S A. 1990 Feb;87(4):1362-6. - Pubmed
DTHybrid score 0.2156
Beta-glucosidase A
Name Beta-glucosidase A
Gene Name bglA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.8064
Cyclomaltodextrin glucanotransferase
Name Cyclomaltodextrin glucanotransferase
Gene Name cgt
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.0052

Predictions


Id Partner name Gene Name Score
3289 Beta-glucosidase A bglA 1.8064
5983 Alpha-mannosidase 2 MAN2A1 0.2526
2245 Xylose isomerase xylA 0.2156
2260 Xylose isomerase xylA 0.2156
2431 Xylose isomerase xylA 0.2156
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.1858
2541 Neopullulanase 1 tvaI 0.1858
2531 Alpha-amylase amyE 0.1857
2948 Alpha-amylase amy 0.1857
3169 Alpha-amylase Not Available 0.1857
2252 Endoglucanase 5A cel5A 0.1679
2248 Malate synthase G glcB 0.1098
3190 Malate synthase G glcB 0.1098
3677 Penicillin-insensitive murein endopeptidase precursor mepA 0.094
2344 Ribosomal small subunit pseudouridine synthase A rsuA 0.094
3706 Ribosomal small subunit pseudouridine synthase A rsuA 0.094
4272 POSSIBLE CELLULASE CELA1 celA1 0.0795
2485 Hyaluronate lyase SP_0314 0.0672
3172 Hyaluronate lyase hylB 0.0672
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0542
2981 Phospholipase A2, membrane associated PLA2G2A 0.0528
1184 Interferon beta IFNB1 0.0214
4666 Fucose-binding lectin PA-IIL lecB 0.0187
2372 Bifunctional tail protein 9 0.0186
1072 Granzyme B GZMB 0.0178
4878 Glycoprotein hormones alpha chain CGA 0.0178
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0178
4877 Beta-mannanase man 0.0178
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0178
4856 CD209 antigen CD209 0.0178
4880 Membrane cofactor protein CD46 0.0178
4850 Beta-2-glycoprotein 1 APOH 0.0178
4889 Ig epsilon chain C region IGHE 0.0178
4189 Alpha-galactosidase A GLA 0.0178
4869 Major capsid protein A430L 0.0178
4852 Reticulon-4 receptor RTN4R 0.0178
442 Envelope glycoprotein gp41 0.0178
4859 Envelope glycoprotein env 0.0178
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0178
757 Fusion glycoprotein F0 F 0.0178
4875 Fusion glycoprotein F0 F 0.0178
4845 ADAM 33 ADAM33 0.0178
4721 Beta-1,4-mannanase manA 0.0178
3352 Structural polyprotein Not Available 0.0178
3628 Structural polyprotein Not Available 0.0178
4892 Structural polyprotein Not Available 0.0178
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0178
1354 Beta-glucuronidase GUSB 0.0178
2430 Chondroitinase B cslB 0.0158
793 T-cell surface antigen CD2 CD2 0.0155
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0155
6858 Inactive carboxylesterase 4 CES1P1 0.0155
1379 Interleukin-12 subunit beta IL12B 0.0155
4890 Hemagglutinin HA 0.0155
6566 Hemagglutinin Not Available 0.0155
4861 Interleukin-6 receptor alpha chain IL6R 0.0155
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0155
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0155
3837 Cytokine receptor common beta chain CSF2RB 0.0155
3444 Cyanovirin-N Not Available 0.0143
1859 Prostatic acid phosphatase ACPP 0.0143
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0143
3140 Hemagglutinin-neuraminidase HN 0.0143
3609 Hemagglutinin-neuraminidase HN 0.0143
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0143
2297 Genome polyprotein Not Available 0.0143
2322 Genome polyprotein Not Available 0.0143
2694 Genome polyprotein Not Available 0.0143
2719 Genome polyprotein Not Available 0.0143
2860 Genome polyprotein Not Available 0.0143
2928 Genome polyprotein Not Available 0.0143
3160 Genome polyprotein Not Available 0.0143
3260 Genome polyprotein Not Available 0.0143
4783 Genome polyprotein Not Available 0.0143
5726 Genome polyprotein Not Available 0.0143
5779 Genome polyprotein Not Available 0.0143
5867 Genome polyprotein Not Available 0.0143
6253 Genome polyprotein Not Available 0.0143
6301 Genome polyprotein Not Available 0.0143
6380 Genome polyprotein Not Available 0.0143
6381 Genome polyprotein Not Available 0.0143
6437 Genome polyprotein Not Available 0.0143
6520 Genome polyprotein Not Available 0.0143
6521 Genome polyprotein Not Available 0.0143
6652 Genome polyprotein Not Available 0.0143
6734 Genome polyprotein Not Available 0.0143
6735 Genome polyprotein Not Available 0.0143
6736 Genome polyprotein Not Available 0.0143
6737 Genome polyprotein Not Available 0.0143
6738 Genome polyprotein Not Available 0.0143
6739 Genome polyprotein Not Available 0.0143
6744 Genome polyprotein Not Available 0.0143
6748 Genome polyprotein Not Available 0.0143
6894 Genome polyprotein Not Available 0.0143
6898 Genome polyprotein Not Available 0.0143
4787 Envelope glycoprotein gp160 env 0.0135
4820 Envelope glycoprotein gp160 env 0.0135
5727 Envelope glycoprotein gp160 env 0.0135
554 Low-density lipoprotein receptor LDLR 0.0132
852 Heparin cofactor 2 SERPIND1 0.013
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.013
3480 Mannan endo-1,4-beta-mannosidase manA 0.0125
64 Neuraminidase NA 0.0125
641 Neuraminidase NA 0.0125
2676 Neuraminidase NA 0.0125
3026 Neuraminidase NA 0.0125
3519 Neuraminidase NA 0.0125
6007 Neuraminidase NA 0.0125
1439 Lactotransferrin LTF 0.0121
595 Fibrinogen alpha chain FGA 0.0119
1243 Cathepsin D CTSD 0.0118
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0116
958 Insulin-like growth factor 1 receptor IGF1R 0.0115
6307 Ig gamma-2 chain C region IGHG2 0.0113
2581 Chondroitinase AC cslA 0.0112
6847 Lactase-phlorizin hydrolase LCT 0.011
6500 Phospholipase A2 PLA2G1B 0.0109
2207 Rhodopsin RHO 0.0101
309 Antithrombin-III SERPINC1 0.01
3814 Complement C1r subcomponent C1R 0.0099
4785 Ig gamma-1 chain C region IGHG1 0.0093
76 Nitric-oxide synthase, brain NOS1 0.0091
4604 Liver carboxylesterase 1 CES1 0.0081
952 Dipeptidyl peptidase 4 DPP4 0.008
20 Prostaglandin G/H synthase 1 PTGS1 0.0074
3689 Endoglucanase A celA 0.0068
5411 Slt-IIvB stxB2e 0.0068
5563 Galectin-2 LGALS2 0.0068
5046 Ecotin eco 0.0068
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0068
5562 Hexokinase Not Available 0.0068
5559 Neopullulanase nplT 0.0068
5554 D-galactose-binding periplasmic protein mglB 0.0068
3741 D-galactose-binding periplasmic protein precursor mglB 0.0068
5568 Endoglucanase C307 celC307 0.0068
1875 Pulmonary surfactant-associated protein D SFTPD 0.0068
3009 Beta-glucanase Not Available 0.0068
3793 Aspartate ammonia-lyase aspA 0.0068
5569 Endo-1,4-beta glucanase EngF engF 0.0068
5553 Endoglucanase E1 Acel_0614 0.0068
4670 Cellulase B celB 0.0068
4668 Laminarinase TM_0024 0.0068
3744 Endoglucanase SS precursor celS 0.0068
5570 Endoglucanase E-4 celD 0.0068
4667 BH0236 protein BH0236 0.0068
4671 Endoglucanase C cenC 0.0068
3923 Cholinesterase BCHE 0.0062
1503 Galectin-7 LGALS7 0.0059
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0059
4509 Acetoin(diacetyl) reductase budC 0.0059
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0059
4622 Amylase Not Available 0.0059
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0059
5416 Coat protein VP1 Not Available 0.0059
5247 Endo-1,4-beta-xylanase Not Available 0.0059
5248 Endo-1,4-beta-xylanase xlnA 0.0059
5250 Endo-1,4-beta-xylanase xyl 0.0059
5176 YtnJ moxC 0.0059
5498 Maltoporin lamB 0.0059
5561 Maltoporin lamB 0.0059
4669 Endo-1,4-beta-xylanase A xynA 0.0059
4715 Endo-1,4-beta-xylanase A xlnA 0.0059
5560 Endo-1,4-beta-xylanase A xynA 0.0059
2705 Dimethyl sulfoxide reductase dmsA 0.0059
3747 Cellulase B precursor celB 0.0054
2606 Neopullulanase 2 tvaII 0.0054
3547 Enterotoxin type B entB 0.0054
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0054
4819 Hydrolase Not Available 0.0054
5249 Hydrolase Not Available 0.0054
5436 Hydrolase Not Available 0.0054
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0054
3091 Maltodextrin phosphorylase malP 0.0054
4811 Amylosucrase ams 0.0054
2324 Botulinum neurotoxin type B botB 0.0054
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0052
2523 Cyclomaltodextrin glucanotransferase cgt 0.0052
3207 Cyclomaltodextrin glucanotransferase amyA 0.0052
3225 Shiga toxin B-chain stxB 0.0051
2826 Glucose--fructose oxidoreductase gfo 0.0051
4830 Aldose 1-epimerase galM 0.0051
3365 Beta-amylase spoII 0.0051
1881 Hexokinase-1 HK1 0.0051
1675 Glucokinase GCK 0.0049
4662 Glucokinase glk 0.0049
3030 Salivary alpha-amylase AMY1A 0.0049
6614 Lactase-like protein LCTL 0.0049
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0047
3668 Maltose-binding periplasmic protein precursor malE 0.0047
2802 Endoglucanase G celCCG 0.0047
2570 Tetanus toxin tetX 0.0047
4692 A/G-specific adenine glycosylase mutY 0.0047
2440 Endoglucanase F celCCF 0.0045
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0043
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0043
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0043
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0043
2723 Cholera enterotoxin subunit B ctxB 0.004
10 Glycogen phosphorylase, liver form PYGL 0.0038
4513 Pancreatic alpha-amylase AMY2A 0.0038
2427 Ferrichrome-iron receptor fhuA 0.0038
1152 Glycogen phosphorylase, muscle form PYGM 0.0031
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