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DB03187 - 6-(Hydroxyethyldithio)-8-(Aminomethylthio)Octanoic Acid


Identification
Name 6-(Hydroxyethyldithio)-8-(Aminomethylthio)Octanoic Acid
Accession Number DB03187 (EXPT02450)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 313.5
Groups experimental
Monoisotopic Weight 313.084005677
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Glycine cleavage system H protein, mitochondrial
Name Glycine cleavage system H protein, mitochondrial
Gene Name GCSH
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.7474

Predictions


Id Partner name Gene Name Score
3082 Aminomethyltransferase gcvT 0.1365
6839 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial PDK3 0.1356
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.1112
1088 5-aminolevulinate synthase, erythroid-specific, mitochondrial ALAS2 0.0159
4058 Glycine N-acyltransferase-like protein 2 GLYATL2 0.0158
4057 Glycine N-acyltransferase GLYAT 0.0158
4059 Glycine N-acyltransferase-like protein 1 GLYATL1 0.0158
4060 Vesicular inhibitory amino acid transporter SLC32A1 0.0158
4061 Peroxisomal sarcosine oxidase PIPOX 0.0158
4055 Bile acid CoA:amino acid N-acyltransferase BAAT 0.0158
1236 Sodium- and chloride-dependent glycine transporter 1 SLC6A9 0.0158
4056 N-arachidonyl glycine receptor GPR18 0.0158
4062 Sodium- and chloride-dependent glycine transporter 2 SLC6A5 0.0158
1466 Glycyl-tRNA synthetase GARS 0.0158
383 Glycine amidinotransferase, mitochondrial GATM 0.0123
411 Glycine N-methyltransferase GNMT 0.0123
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0121
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0121
62 Glycine receptor subunit beta GLRB 0.0121
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0121
207 Glutathione synthetase GSS 0.0116
5269 Glutathione synthetase gshB 0.0116
593 Proton-coupled amino acid transporter 1 SLC36A1 0.011
349 Serine--pyruvate aminotransferase AGXT 0.0109
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0108
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0108
3879 Serine hydroxymethyltransferase 2 Not Available 0.0108
3884 SHMT2 protein SHMT2 0.0108
3901 SHMT2 protein SHMT2 0.0108
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0107
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0104
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0102
820 Glycine receptor subunit alpha-2 GLRA2 0.0098
461 Glycine receptor subunit alpha-3 GLRA3 0.0098
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0096
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0087
482 Glycine receptor subunit alpha-1 GLRA1 0.0085
6151 Monocarboxylate transporter 10 SLC16A10 0.0076
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