DT-Web

DB03176 - 3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid


Identification
Name 3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid
Accession Number DB03176 (EXPT01852)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 355.213
Groups experimental
Monoisotopic Weight 354.042564414
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Thyroid hormone receptor beta-1
Name Thyroid hormone receptor beta-1
Gene Name THRB
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.225
Thyroid hormone receptor alpha
Name Thyroid hormone receptor alpha
Gene Name THRA
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.4226

Predictions


Id Partner name Gene Name Score
6369 Thyroid hormone receptor, alpha isoform 1 variant Not Available 0.1207
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.1048
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.103
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0959
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0908
594 Thyroxine-binding globulin SERPINA7 0.0907
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0668
373 Transthyretin TTR 0.0483
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0462
563 Thyroid peroxidase TPO 0.0462
199 Monocarboxylate transporter 8 SLC16A2 0.0445
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0386
6141 Sodium/bile acid cotransporter SLC10A1 0.0349
587 Serum albumin ALB 0.0337
6151 Monocarboxylate transporter 10 SLC16A10 0.0303
1588 Multidrug resistance protein 1 ABCB1 0.0282
6142 Solute carrier family 22 member 8 SLC22A8 0.0243
4924 Cytochrome P450 2C8 CYP2C8 0.0204
4512 Cytochrome P450 3A4 CYP3A4 0.0084
↑