DT-Web

DB02998 - Methyltrienolone


Identification
Name Methyltrienolone
Accession Number DB02998 (EXPT02741)
Type small molecule
Description A synthetic non-aromatizable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 284.3927
Groups experimental
Monoisotopic Weight 284.177630012
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Progesterone receptor
Name Progesterone receptor
Gene Name PGR
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.6159
Androgen receptor
Name Androgen receptor
Gene Name AR
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.0985
Nuclear receptor coactivator 2
Name Nuclear receptor coactivator 2
Gene Name NCOA2
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.8906

Predictions


Id Partner name Gene Name Score
136 Estrogen receptor ESR1 0.5542
459 Retinoic acid receptor RXR-alpha RXRA 0.0796
3811 Cytochrome P450 19A1 CYP19A1 0.0787
4512 Cytochrome P450 3A4 CYP3A4 0.062
756 Sex hormone-binding globulin SHBG 0.059
737 Mineralocorticoid receptor NR3C2 0.056
2202 Steryl-sulfatase STS 0.0552
871 Glucocorticoid receptor NR3C1 0.0518
6283 Oxysterols receptor LXR-alpha NR1H3 0.0516
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0379
1588 Multidrug resistance protein 1 ABCB1 0.0327
88 Retinoic acid receptor RXR-beta RXRB 0.0326
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0254
4118 Cytochrome P450 3A5 CYP3A5 0.0217
6016 Cytochrome P450 2C19 CYP2C19 0.0191
6228 Nuclear receptor coactivator 1 NCOA1 0.019
1649 Small inducible cytokine A2 CCL2 0.0189
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0185
290 Prostaglandin G/H synthase 2 PTGS2 0.0184
6107 Cytochrome P450 3A7 CYP3A7 0.0181
4924 Cytochrome P450 2C8 CYP2C8 0.0178
4757 Cytochrome P450 2C9 CYP2C9 0.0173
2907 Oxysterols receptor LXR-beta NR1H2 0.0172
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0167
226 Gonadotropin-releasing hormone receptor GNRHR 0.0158
3923 Cholinesterase BCHE 0.0147
381 Prolactin receptor PRLR 0.013
862 Multidrug resistance-associated protein 1 ABCC1 0.0121
3810 Catechol O-methyltransferase COMT 0.0119
4119 Cytochrome P450 2D6 CYP2D6 0.0112
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.011
587 Serum albumin ALB 0.011
373 Transthyretin TTR 0.0109
380 Cytochrome P450 17A1 CYP17A1 0.0098
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0096
723 Cytosolic phospholipase A2 PLA2G4A 0.0091
232 Corticosteroid-binding globulin SERPINA6 0.0088
3941 Amine oxidase [flavin-containing] A MAOA 0.0084
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0081
992 Protein tyrosine kinase 2 beta PTK2B 0.0078
3939 Amine oxidase [flavin-containing] B MAOB 0.0078
4120 NADPH--cytochrome P450 reductase POR 0.0074
1898 Cytochrome P450 1B1 CYP1B1 0.0071
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0071
4200 Cytochrome P450 1A2 CYP1A2 0.0068
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0066
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0061
6030 Cytochrome P450 2B6 CYP2B6 0.0059
869 Estrogen receptor beta ESR2 0.0058
6024 Cytochrome P450 1A1 CYP1A1 0.0057
6220 Aryl hydrocarbon receptor AHR 0.0053
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0048
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0047
817 DNA topoisomerase 2-alpha TOP2A 0.0044
6141 Sodium/bile acid cotransporter SLC10A1 0.0044
6142 Solute carrier family 22 member 8 SLC22A8 0.004
20 Prostaglandin G/H synthase 1 PTGS1 0.0039
1729 Solute carrier family 22 member 6 SLC22A6 0.0037
6147 Solute carrier family 22 member 3 SLC22A3 0.0036
6145 Solute carrier family 22 member 1 SLC22A1 0.003
776 Bile salt export pump ABCB11 0.0025
6144 Solute carrier family 22 member 2 SLC22A2 0.0021
5718 Cytochrome P450 2A6 CYP2A6 0.002
6014 Cytochrome P450 2A13 CYP2A13 0.0018
6031 Cytochrome P450 3A43 CYP3A43 0.0014
833 Organic cation/carnitine transporter 1 SLC22A4 0.0011
6143 Solute carrier family 22 member 7 SLC22A7 0.001
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