DT-Web

DB02868 - 3''-(Beta-Chloroethyl)-2'',4''-Dioxo-3, 5''-Spiro-Oxazolidino-4-Deacetoxy-Vinblastine


Identification
Name 3''-(Beta-Chloroethyl)-2'',4''-Dioxo-3, 5''-Spiro-Oxazolidino-4-Deacetoxy-Vinblastine
Accession Number DB02868 (EXPT01963)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 825.411
Groups experimental
Monoisotopic Weight 824.379001846
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Calmodulin
Name Calmodulin
Gene Name CALM1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.3689

Predictions


Id Partner name Gene Name Score
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0464
1507 Cytochrome c CYCS 0.0356
722 Troponin I, cardiac muscle TNNI3 0.0347
4119 Cytochrome P450 2D6 CYP2D6 0.03
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0224
1588 Multidrug resistance protein 1 ABCB1 0.0208
831 D(2) dopamine receptor DRD2 0.0191
4200 Cytochrome P450 1A2 CYP1A2 0.0183
6030 Cytochrome P450 2B6 CYP2B6 0.018
1089 Cartilage oligomeric matrix protein COMP 0.0168
1108 Calpastatin CAST 0.0168
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0159
6048 Troponin C, skeletal muscle TNNC2 0.0157
2392 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0146
3032 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0146
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.014
6013 Cytochrome P450 2E1 CYP2E1 0.0138
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0132
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0132
4757 Cytochrome P450 2C9 CYP2C9 0.013
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0129
4512 Cytochrome P450 3A4 CYP3A4 0.0128
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0127
2314 Triosephosphate isomerase TPI 0.0123
3417 Triosephosphate isomerase tpiA 0.0123
3443 Triosephosphate isomerase tpiA 0.0123
6346 Triosephosphate isomerase TPI1 0.0123
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.012
556 Alpha-1A adrenergic receptor ADRA1A 0.0118
2795 Methionine aminopeptidase 2 METAP2 0.0117
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0109
5682 Ribonuclease pancreatic RNASE1 0.0104
4924 Cytochrome P450 2C8 CYP2C8 0.0101
3923 Cholinesterase BCHE 0.01
23 D(1A) dopamine receptor DRD1 0.0098
2132 Protein S100-B S100B 0.0096
6859 Protein S100-A4 S100A4 0.0094
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0087
6016 Cytochrome P450 2C19 CYP2C19 0.0083
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0079
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0076
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0075
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0075
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0072
4118 Cytochrome P450 3A5 CYP3A5 0.007
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.007
6024 Cytochrome P450 1A1 CYP1A1 0.0069
1262 Corticotropin-lipotropin POMC 0.0064
492 Histamine H1 receptor HRH1 0.0062
6107 Cytochrome P450 3A7 CYP3A7 0.006
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0057
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0057
705 Glutamate receptor 1 GRIA1 0.0056
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0054
3830 Calreticulin CALR 0.0053
537 ATP synthase delta chain, mitochondrial ATP5D 0.0053
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0052
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0052
5718 Cytochrome P450 2A6 CYP2A6 0.0052
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0051
450 Muscarinic acetylcholine receptor M4 CHRM4 0.005
6035 Nuclear receptor ROR-beta RORB 0.005
6034 Hydroxyindole O-methyltransferase ASMT 0.005
482 Glycine receptor subunit alpha-1 GLRA1 0.005
6036 Eosinophil peroxidase EPX 0.005
3947 Xanthine dehydrogenase/oxidase XDH 0.0048
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0047
378 Alpha-2C adrenergic receptor ADRA2C 0.0046
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0045
629 Alpha-2B adrenergic receptor ADRA2B 0.0045
6147 Solute carrier family 22 member 3 SLC22A3 0.0045
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0044
765 Indoleamine 2,3-dioxygenase IDO1 0.0044
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0043
362 Melatonin receptor type 1B MTNR1B 0.0042
571 Melatonin receptor type 1A MTNR1A 0.0042
766 Beta-2 adrenergic receptor ADRB2 0.0042
6106 Cytochrome P450 2C18 CYP2C18 0.0042
467 Delta-type opioid receptor OPRD1 0.0041
696 Kappa-type opioid receptor OPRK1 0.0041
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.004
318 Alpha-2A adrenergic receptor ADRA2A 0.004
6144 Solute carrier family 22 member 2 SLC22A2 0.0039
587 Serum albumin ALB 0.0039
638 D(3) dopamine receptor DRD3 0.0039
847 Mu-type opioid receptor OPRM1 0.0039
6145 Solute carrier family 22 member 1 SLC22A1 0.0038
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0034
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0033
502 5-hydroxytryptamine 2A receptor HTR2A 0.0028
1757 Myeloperoxidase MPO 0.0028
737 Mineralocorticoid receptor NR3C2 0.0027
1898 Cytochrome P450 1B1 CYP1B1 0.0024
3811 Cytochrome P450 19A1 CYP19A1 0.0024
136 Estrogen receptor ESR1 0.0023
394 Calcineurin subunit B isoform 1 PPP3R1 0.0022
6742 Recoverin RCVRN 0.0022
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0022
2528 Fatty acid metabolism regulator protein fadR 0.0022
6740 Fatty acid metabolism regulator protein fadR 0.0022
6753 Apolipoprotein M APOM 0.0022
6747 Chalcone/stilbene synthase family protein MT1417 0.0022
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0022
6743 Non-fluorescent flavoprotein luxF 0.0022
6751 Gag polyprotein gag 0.0022
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0022
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0022
6749 Polyprotein Not Available 0.0022
6142 Solute carrier family 22 member 8 SLC22A8 0.0021
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0021
789 Alpha-1D adrenergic receptor ADRA1D 0.002
5961 Insulin INS 0.002
6755 Poliovirus receptor PVR 0.0019
6527 Lymphocyte antigen 96 LY96 0.0019
632 Alpha-1B adrenergic receptor ADRA1B 0.0018
6750 ADP-ribosylation factor 6 ARF6 0.0018
6524 Protein tonB tonB 0.0018
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0018
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0018
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0017
4210 Toll-like receptor 4 TLR4 0.0017
2616 Ganglioside GM2 activator GM2A 0.0017
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0016
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0016
2297 Genome polyprotein Not Available 0.0015
2322 Genome polyprotein Not Available 0.0015
2694 Genome polyprotein Not Available 0.0015
2719 Genome polyprotein Not Available 0.0015
2860 Genome polyprotein Not Available 0.0015
2928 Genome polyprotein Not Available 0.0015
3160 Genome polyprotein Not Available 0.0015
3260 Genome polyprotein Not Available 0.0015
4783 Genome polyprotein Not Available 0.0015
5726 Genome polyprotein Not Available 0.0015
5779 Genome polyprotein Not Available 0.0015
5867 Genome polyprotein Not Available 0.0015
6253 Genome polyprotein Not Available 0.0015
6301 Genome polyprotein Not Available 0.0015
6380 Genome polyprotein Not Available 0.0015
6381 Genome polyprotein Not Available 0.0015
6437 Genome polyprotein Not Available 0.0015
6520 Genome polyprotein Not Available 0.0015
6521 Genome polyprotein Not Available 0.0015
6652 Genome polyprotein Not Available 0.0015
6734 Genome polyprotein Not Available 0.0015
6735 Genome polyprotein Not Available 0.0015
6736 Genome polyprotein Not Available 0.0015
6737 Genome polyprotein Not Available 0.0015
6738 Genome polyprotein Not Available 0.0015
6739 Genome polyprotein Not Available 0.0015
6744 Genome polyprotein Not Available 0.0015
6748 Genome polyprotein Not Available 0.0015
6894 Genome polyprotein Not Available 0.0015
6898 Genome polyprotein Not Available 0.0015
6316 ADP-ribosylation factor 1 ARF1 0.0015
6085 Fatty acid-binding protein, intestinal FABP2 0.0014
864 Gag-Pol polyprotein gag-pol 0.0014
2237 Gag-Pol polyprotein gag-pol 0.0014
2326 Gag-Pol polyprotein gag-pol 0.0014
2451 Gag-Pol polyprotein gag-pol 0.0014
2901 Gag-Pol polyprotein gag-pol 0.0014
3165 Gag-Pol polyprotein gag-pol 0.0014
3722 Gag-Pol polyprotein gag-pol 0.0014
6306 Gag-Pol polyprotein gag-pol 0.0014
6624 Gag-Pol polyprotein gag-pol 0.0014
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0013
768 FK506-binding protein 1A FKBP1A 0.0012
2427 Ferrichrome-iron receptor fhuA 0.0012
6228 Nuclear receptor coactivator 1 NCOA1 0.0012
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0011
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0011
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