DT-Web

DB02789 - Pregnenolone


Identification
Name Pregnenolone
Accession Number DB02789 (EXPT02608)
Type small molecule
Description A 21-carbon steroid, derived from CHOLESTEROL and found in steroid hormone-producing tissues. Pregnenolone is the precursor to GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 316.4776
Groups experimental
Monoisotopic Weight 316.240230268
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Sulfotransferase family cytosolic 2B member 1
Name Sulfotransferase family cytosolic 2B member 1
Gene Name SULT2B1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.7169

Transporters


Solute carrier family 10 member 6
Name Solute carrier family 10 member 6
Gene Name Not Available
Actions Not Available
References
  • Geyer J, Doring B, Meerkamp K, Ugele B, Bakhiya N, Fernandes CF, Godoy JR, Glatt H, Petzinger E: Cloning and functional characterization of human sodium-dependent organic anion transporter (SLC10A6). J Biol Chem. 2007 Jul 6;282(27):19728-41. Epub 2007 May 9. - Pubmed
DTHybrid score Not Available

Predictions


Id Partner name Gene Name Score
3497 Ribonuclease PH rph 0.1124
5214 Phosphoprotein P/V 0.1124
3444 Cyanovirin-N Not Available 0.0904
1050 Bile salt sulfotransferase SULT2A1 0.0865
3127 Nitrite reductase nirS 0.0851
3284 Nitrite reductase nirS 0.0851
2268 Cholesterol oxidase choB 0.0699
2822 Cholesterol oxidase choA 0.0699
2283 Steroid Delta-isomerase ksi 0.0645
2920 Steroid Delta-isomerase ksi 0.0645
4382 Sulfotransferase family cytosolic 1B member 1 SULT1B1 0.0513
3317 Holo-[acyl-carrier-protein] synthase acpS 0.0511
4381 Holo-[acyl-carrier-protein] synthase acpS 0.0511
4380 Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 NDST1 0.051
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0465
2390 Nonsecretory ribonuclease RNASE2 0.041
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.037
1353 DNA topoisomerase 1 TOP1 0.0364
3552 DNA topoisomerase 1 topA 0.0364
1275 Estrogen sulfotransferase SULT1E1 0.0312
1192 Sulfotransferase 1A1 SULT1A1 0.031
5682 Ribonuclease pancreatic RNASE1 0.0255
6107 Cytochrome P450 3A7 CYP3A7 0.0197
4512 Cytochrome P450 3A4 CYP3A4 0.0156
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