DT-Web

DB02718 - 5-Formyl-6-Hydrofolic Acid


Identification
Name 5-Formyl-6-Hydrofolic Acid
Accession Number DB02718 (EXPT01428)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 471.4234
Groups experimental
Monoisotopic Weight 471.150246061
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Serine hydroxymethyltransferase
Name Serine hydroxymethyltransferase
Gene Name glyA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9063
Dihydrofolate reductase
Name Dihydrofolate reductase
Gene Name folA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.0029

Predictions


Id Partner name Gene Name Score
3193 Serine hydroxymethyltransferase glyA 0.9063
4823 L-allo-threonine aldolase TM_1744 0.1963
4582 Putative pteridine reductase 2 ptr2 0.1619
449 Ornithine decarboxylase ODC1 0.1483
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.1382
2636 Shikimate dehydrogenase aroE 0.1199
3515 Shikimate dehydrogenase aroE 0.1199
3627 UPF0190 protein yedY yedY 0.0599
1392 Catenin beta-1 CTNNB1 0.0599
3352 Structural polyprotein Not Available 0.0598
3628 Structural polyprotein Not Available 0.0598
4892 Structural polyprotein Not Available 0.0598
5682 Ribonuclease pancreatic RNASE1 0.0598
315 Arginase-1 ARG1 0.0353
357 Carbonic anhydrase 2 CA2 0.0221
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0062
4403 Protein iolS iolS 0.0062
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0062
5322 Oxidoreductase ydhF ydhF 0.0062
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0062
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0062
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0062
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0062
5332 MtdA bifunctional protein mtdA 0.0062
5330 General stress protein 69 yhdN 0.0062
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0062
3778 NAD(P) transhydrogenase subunit beta pntB 0.0062
989 L-xylulose reductase DCXR 0.0054
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0054
5073 Ferredoxin--NADP reductase petH 0.0054
5076 Ferredoxin--NADP reductase fpr 0.0054
5119 Ferredoxin--NADP reductase petH 0.0054
5121 Ferredoxin--NADP reductase fpr 0.0054
5328 Prostaglandin F synthase Tb11.02.2310 0.0054
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0054
729 GDP-L-fucose synthetase TSTA3 0.0054
3463 GDP-L-fucose synthetase fcl 0.0054
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.0054
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0054
3446 NADP-dependent alcohol dehydrogenase adh 0.0054
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0054
2286 Isocitrate dehydrogenase [NADP] icd 0.0054
2302 Isocitrate dehydrogenase [NADP] icd 0.0054
2771 Isocitrate dehydrogenase [NADP] icd 0.0054
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0054
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0054
4531 Putative ketoacyl reductase actIII 0.005
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.005
6297 Prostaglandin reductase 1 PTGR1 0.005
3062 Aspartate-semialdehyde dehydrogenase asd 0.005
1124 Sepiapterin reductase SPR 0.0047
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0047
2675 Pteridine reductase 1 PTR1 0.0047
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0047
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0045
666 NADP-dependent malic enzyme ME1 0.0045
646 Malate dehydrogenase, cytoplasmic MDH1 0.0044
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0044
2159 Quinone oxidoreductase CRYZ 0.0043
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0039
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0039
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0039
654 Flavin reductase BLVRB 0.0038
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0035
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0035
444 Alcohol dehydrogenase 1B ADH1B 0.0035
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0033
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0033
76 Nitric-oxide synthase, brain NOS1 0.0031
822 Aldose reductase AKR1B1 0.0031
365 Dihydrofolate reductase DHFR 0.0029
2381 Dihydrofolate reductase DFR1 0.0029
2833 Dihydrofolate reductase Not Available 0.0029
2931 Dihydrofolate reductase folA 0.0029
3544 Dihydrofolate reductase folA 0.0029
6642 Dihydrofolate reductase folA 0.0029
6756 Dihydrofolate reductase dfrA 0.0029
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0029
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0029
4120 NADPH--cytochrome P450 reductase POR 0.0028
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