DT-Web

DB02240 - N-{(1s)-4-[Bis(2-Chloroethyl)Amino]-1-Methylbutyl}-N-(6-Chloro-2-Methoxy-9-Acridinyl)Amine


Identification
Name N-{(1s)-4-[Bis(2-Chloroethyl)Amino]-1-Methylbutyl}-N-(6-Chloro-2-Methoxy-9-Acridinyl)Amine
Accession Number DB02240 (EXPT02733)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 468.847
Groups experimental
Monoisotopic Weight 467.129795654
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Trypanothione reductase
Name Trypanothione reductase
Gene Name TPR
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.1063

Predictions


Id Partner name Gene Name Score
2537 Aromatic-amino-acid aminotransferase tyrB 0.0695
2249 Aspartate aminotransferase aspC 0.0644
2671 Aspartate aminotransferase aspC 0.0644
5490 Aspartate aminotransferase Not Available 0.0644
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0565
5109 Outer membrane protein p64k or PM-6 m-6 0.007
3763 5,10-methylenetetrahydrofolate reductase metF 0.007
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.007
5094 5,10-methylenetetrahydrofolate reductase metF 0.007
5122 Mersacidin decarboxylase mrsD 0.007
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.007
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.007
5095 Putidaredoxin reductase camA 0.007
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.007
526 Thioredoxin reductase trxB 0.007
3767 Thioredoxin reductase trxB 0.007
5078 Amine oxidase, flavin-containing PSPTO1126 0.007
5115 FkbI fkbI 0.007
3133 UDP-galactopyranose mutase glf 0.007
5099 UDP-galactopyranose mutase glf 0.007
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.007
5083 Cryptochrome DASH cry 0.007
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.007
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.007
5081 L-aspartate oxidase nadB 0.007
5111 Phenylacetone monooxygenase pamO 0.007
1410 Oxidoreductase HSD17B6 0.007
4725 Oxidoreductase Not Available 0.007
5124 Oxidoreductase Not Available 0.007
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.007
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.007
4486 Phenol 2-hydroxylase component B pheA2 0.0061
4477 Dihydrolipoyl dehydrogenase lpdV 0.0061
5077 Dihydrolipoyl dehydrogenase Not Available 0.0061
5117 Dihydrolipoyl dehydrogenase lpd 0.0061
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0061
4439 Ferredoxin reductase bphA4 0.0061
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0061
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0061
2470 Pyruvate oxidase pox5 0.0061
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0061
3594 Deoxyribodipyrimidine photo-lyase phr 0.0061
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0061
5080 Deoxyribodipyrimidine photo-lyase phr 0.0061
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0061
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0061
5073 Ferredoxin--NADP reductase petH 0.0061
5076 Ferredoxin--NADP reductase fpr 0.0061
5119 Ferredoxin--NADP reductase petH 0.0061
5121 Ferredoxin--NADP reductase fpr 0.0061
2526 NADPH-ferredoxin reductase fprA fprA 0.0061
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0061
2268 Cholesterol oxidase choB 0.0061
2822 Cholesterol oxidase choA 0.0061
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0061
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0061
5072 N,N-dimethylglycine oxidase dmg 0.0061
4440 NADH peroxidase npr 0.0056
2893 Glycine oxidase thiO 0.0056
3102 Flavohemoprotein hmp 0.0056
4969 Flavohemoprotein hmp 0.0056
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0056
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0056
2567 Thymidylate synthase thyX thyX 0.0053
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0053
2769 P-hydroxybenzoate hydroxylase pobA 0.0051
2809 P-hydroxybenzoate hydroxylase pobA 0.0051
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.005
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.005
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.005
327 Glutathione reductase gor 0.0049
5110 Glutathione reductase GR2 0.0049
2380 Monomeric sarcosine oxidase soxA 0.0049
126 D-lactate dehydrogenase dld 0.0049
3545 D-lactate dehydrogenase Not Available 0.0049
4510 D-lactate dehydrogenase ldhA 0.0049
605 Fumarate reductase flavoprotein subunit frdA 0.0048
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0048
3673 Fumarate reductase flavoprotein subunit fccA 0.0048
4912 Fumarate reductase flavoprotein subunit ifcA 0.0048
6549 Fumarate reductase flavoprotein subunit frdA 0.0048
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0047
6645 D-amino-acid oxidase DAO 0.0046
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0041
714 Glutathione reductase, mitochondrial GSR 0.0037
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0037
76 Nitric-oxide synthase, brain NOS1 0.0035
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0033
4120 NADPH--cytochrome P450 reductase POR 0.0031
3939 Amine oxidase [flavin-containing] B MAOB 0.0027
3947 Xanthine dehydrogenase/oxidase XDH 0.0026
3941 Amine oxidase [flavin-containing] A MAOA 0.0024
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