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DB02116 - Olomoucine


Identification
Name Olomoucine
Accession Number DB02116 (EXPT02433)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 298.343
Groups experimental
Monoisotopic Weight 298.154209228
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Cell division protein kinase 2
Name Cell division protein kinase 2
Gene Name CDK2
Pharmacological action unknown
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 2.0863
Cell division protein kinase 5
Name Cell division protein kinase 5
Gene Name CDK5
Pharmacological action unknown
Actions inhibitor
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.2054
Cell division control protein 2 homolog
Name Cell division control protein 2 homolog
Gene Name CDK1
Pharmacological action unknown
Actions binder
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.1049
D-HSCDK2
Name D-HSCDK2
Gene Name CDK2deltaT
Pharmacological action unknown
Actions Not Available
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.107
Mitogen-activated protein kinase 1
Name Mitogen-activated protein kinase 1
Gene Name MAPK1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.1235

Predictions


Id Partner name Gene Name Score
3321 Cell division control protein 2 homolog CRK2 1.1049
6321 Cyclin-dependent kinase 5 activator 1 CDK5R1 0.3312
6235 Cyclin-A2 CCNA2 0.2743
1721 Glycogen synthase kinase-3 beta GSK3B 0.2675
3959 Cell division protein kinase 4 CDK4 0.121
3482 Cell division protein kinase 7 CDK7 0.1068
3950 Cell division protein kinase 9 CDK9 0.1008
3968 Cell division protein kinase 8 CDK8 0.1006
1540 Mitogen-activated protein kinase 14 MAPK14 0.09
3955 Cell division protein kinase 6 CDK6 0.0811
1372 Insulin receptor substrate 1 IRS1 0.065
1836 Mitogen-activated protein kinase 10 MAPK10 0.0554
844 Epidermal growth factor receptor EGFR 0.0537
1152 Glycogen phosphorylase, muscle form PYGM 0.0456
36 Insulin receptor INSR 0.0421
1714 Mitogen-activated protein kinase 3 MAPK3 0.0387
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0297
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0268
1422 Serine/threonine-protein kinase 6 AURKA 0.0239
4750 Protein S100-A11 S100A11 0.0216
2530 Protein kinase C theta type PRKCQ 0.0194
4751 Mitogen-activated protein kinase 12 MAPK12 0.0189
3005 Threonine-phosphate decarboxylase cobD 0.0188
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0181
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0173
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0173
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0127
1517 Beta-3 adrenergic receptor ADRB3 0.0127
2207 Rhodopsin RHO 0.0122
6024 Cytochrome P450 1A1 CYP1A1 0.0115
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0109
1569 G1/S-specific cyclin-D1 CCND1 0.0106
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0102
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0102
1629 Transcription factor AP-1 JUN 0.0086
193 Beta-1 adrenergic receptor ADRB1 0.0086
766 Beta-2 adrenergic receptor ADRB2 0.0083
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0082
1898 Cytochrome P450 1B1 CYP1B1 0.0056
1588 Multidrug resistance protein 1 ABCB1 0.0052
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0048
4512 Cytochrome P450 3A4 CYP3A4 0.0041
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0032
6824 Tyrosine-protein kinase Lyn LYN 0.003
2599 Tyrosine-protein kinase HCK HCK 0.0028
2473 Tyrosine-protein kinase CSK CSK 0.0026
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.0026
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0024
4341 Beta crystallin B1 CRYBB1 0.0024
4340 Hypothetical conserved protein GK2698 0.0024
6484 Hypothetical conserved protein TT_C0834 0.0024
4339 Sucrose phosphorylase sucP 0.0024
1434 Protein DJ-1 PARK7 0.0024
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0024
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0024
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0022
3421 Hydroxyethylthiazole kinase thiM 0.0021
2688 Peptide deformylase def 0.0021
2708 Peptide deformylase def 0.0021
3004 Peptide deformylase def 0.0021
4337 Peptide deformylase def 0.0021
4338 Peptide deformylase def 0.0021
5368 Peptide deformylase def 0.0021
5371 Peptide deformylase def 0.0021
6375 Peptide deformylase def 0.0021
6378 Peptide deformylase def 0.0021
6379 Peptide deformylase def 0.0021
6776 Peptide deformylase def 0.0021
6900 Peptide deformylase def 0.0021
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.002
3105 M-phase inducer phosphatase 2 CDC25B 0.0019
4343 Alpha-glucosidase aglA 0.0019
2408 Tyrosine-protein kinase SYK SYK 0.0018
3168 Beta-lactamase OXA-1 bla 0.0018
3230 Non-ATP-dependent L-selective hydantoinase lhyD 0.0018
4819 Hydrolase Not Available 0.0018
5249 Hydrolase Not Available 0.0018
5436 Hydrolase Not Available 0.0018
3122 D-hydantoinase Not Available 0.0018
3145 D-hydantoinase hyuA 0.0018
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0017
2840 Beta-lactamase IMP-1 Not Available 0.0017
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0016
3873 Prolyl endopeptidase PREP 0.0015
6928 Prolyl endopeptidase Not Available 0.0015
3237 Beta-lactamase OXA-2 bla 0.0015
3292 Alanine racemase, catabolic dadX 0.0015
3281 Isoaspartyl dipeptidase iadA 0.0015
4264 Alpha-L-fucosidase, putative TM_0306 0.0015
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0015
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0015
2801 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase murE 0.0014
2983 Methylmalonyl-CoA carboxyltransferase 5S subunit Not Available 0.0014
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0014
4549 Endonuclease III HP_0602 0.0013
2646 Dihydroorotase pyrC 0.0013
2717 Folylpolyglutamate synthase fgs 0.0013
2340 Beta-lactamase PSE-2 bla 0.0012
2796 Parathion hydrolase opd 0.0012
6539 Parathion hydrolase opd 0.0012
894 Alanine racemase alr 0.0012
2453 Alanine racemase alr 0.0012
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0011
687 Tyrosine-protein phosphatase non-receptor type 1 PTPN1 0.0011
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