DT-Web

DB02052 - Indirubin-3'-Monoxime


Identification
Name Indirubin-3'-Monoxime
Accession Number DB02052 (EXPT01949)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 277.2774
Groups experimental
Monoisotopic Weight 277.085126611
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Cell division protein kinase 5
Name Cell division protein kinase 5
Gene Name CDK5
Pharmacological action unknown
Actions inhibitor
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.6637
Cell division control protein 2 homolog
Name Cell division control protein 2 homolog
Gene Name CDK1
Pharmacological action unknown
Actions binder
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.2358
D-HSCDK2
Name D-HSCDK2
Gene Name CDK2deltaT
Pharmacological action unknown
Actions Not Available
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.2379
Glycogen synthase kinase-3 beta
Name Glycogen synthase kinase-3 beta
Gene Name GSK3B
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.3746
Cyclin-dependent kinase 5 activator 1
Name Cyclin-dependent kinase 5 activator 1
Gene Name CDK5R1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.0199
Cell division protein kinase 2
Name Cell division protein kinase 2
Gene Name CDK2
Pharmacological action unknown
Actions inhibitor
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 2.1343

Predictions


Id Partner name Gene Name Score
3321 Cell division control protein 2 homolog CRK2 1.2358
6235 Cyclin-A2 CCNA2 0.2743
2116 RAC-beta serine/threonine-protein kinase AKT2 0.1438
1176 Mitogen-activated protein kinase 1 MAPK1 0.1381
3950 Cell division protein kinase 9 CDK9 0.1008
3968 Cell division protein kinase 8 CDK8 0.1006
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0943
3959 Cell division protein kinase 4 CDK4 0.0926
3482 Cell division protein kinase 7 CDK7 0.0879
3955 Cell division protein kinase 6 CDK6 0.0811
6545 Calcium/calmodulin-dependent protein kinase type IV CAMK4 0.0661
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0577
844 Epidermal growth factor receptor EGFR 0.0537
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0534
1152 Glycogen phosphorylase, muscle form PYGM 0.0456
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0297
2026 Inositol monophosphatase IMPA1 0.0272
1387 Inositol monophosphatase 2 IMPA2 0.0244
923 Glutamate receptor 3 GRIA3 0.0231
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0214
2473 Tyrosine-protein kinase CSK CSK 0.0143
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.0142
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0124
2530 Protein kinase C theta type PRKCQ 0.0114
1422 Serine/threonine-protein kinase 6 AURKA 0.0113
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0102
2408 Tyrosine-protein kinase SYK SYK 0.01
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0094
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0087
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0083
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0072
5646 Galactokinase GALK1 0.0042
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0042
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0042
5302 TrwB trwB 0.0042
5265 FtsH ftsH 0.0042
1588 Multidrug resistance protein 1 ABCB1 0.0042
5312 Kinesin-like protein KIF1A KIF1A 0.0038
2892 Acetylglutamate kinase argB 0.0036
3550 Acetylglutamate kinase argB 0.0036
2371 Pantothenate kinase coaA 0.0036
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0036
825 Arsenical pump-driving ATPase ASNA1 0.0036
3435 Arsenical pump-driving ATPase arsA 0.0036
2615 Chemotaxis protein cheA cheA 0.0036
1881 Hexokinase-1 HK1 0.0036
2727 S-adenosylmethionine synthetase metK 0.0034
1714 Mitogen-activated protein kinase 3 MAPK3 0.0034
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0033
5641 Rod shape-determining protein MreB TM_0588 0.0033
5645 DNA topoisomerase 4 subunit B parE 0.0033
6227 DNA topoisomerase 4 subunit B parE 0.0033
5644 Sensor protein phoQ phoQ 0.0033
5643 General secretion pathway protein E epsE 0.0033
4178 DNA repair protein RAD51 homolog 1 RAD51 0.0033
5649 Potassium-transporting ATPase B chain kdpB 0.0033
3794 Osmolarity sensor protein envZ envZ 0.0033
5642 Chaperone clpB clpB 0.0033
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0032
6824 Tyrosine-protein kinase Lyn LYN 0.003
2251 Thymidylate kinase tmk 0.0029
2254 Thymidylate kinase DTYMK 0.0029
3522 Thymidylate kinase tmk 0.0029
4751 Mitogen-activated protein kinase 12 MAPK12 0.0029
2867 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ispE 0.0029
740 Argininosuccinate synthase ASS1 0.0029
865 Argininosuccinate synthase ASS1 0.0029
2680 Argininosuccinate synthase argG 0.0029
3194 Argininosuccinate synthase argG 0.0029
6433 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 PFKFB4 0.0029
2397 Dihydroxyacetone kinase dhaK 0.0029
2852 DNA mismatch repair protein mutL mutL 0.0029
2599 Tyrosine-protein kinase HCK HCK 0.0028
3822 Actin, alpha skeletal muscle ACTA1 0.0028
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0028
207 Glutathione synthetase GSS 0.0027
5269 Glutathione synthetase gshB 0.0027
2299 UDP-N-acetylmuramate--L-alanine ligase murC 0.0027
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0026
3231 Death-associated protein kinase 1 DAPK1 0.0026
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0024
4341 Beta crystallin B1 CRYBB1 0.0024
4340 Hypothetical conserved protein GK2698 0.0024
6484 Hypothetical conserved protein TT_C0834 0.0024
4339 Sucrose phosphorylase sucP 0.0024
1434 Protein DJ-1 PARK7 0.0024
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0024
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0024
887 DNA gyrase subunit B gyrB 0.0024
4150 DNA gyrase subunit B gyrB 0.0024
6225 DNA gyrase subunit B gyrB 0.0024
936 Ephrin type-A receptor 2 EPHA2 0.0024
958 Insulin-like growth factor 1 receptor IGF1R 0.0022
3421 Hydroxyethylthiazole kinase thiM 0.0021
2688 Peptide deformylase def 0.0021
2708 Peptide deformylase def 0.0021
3004 Peptide deformylase def 0.0021
4337 Peptide deformylase def 0.0021
4338 Peptide deformylase def 0.0021
5368 Peptide deformylase def 0.0021
5371 Peptide deformylase def 0.0021
6375 Peptide deformylase def 0.0021
6378 Peptide deformylase def 0.0021
6379 Peptide deformylase def 0.0021
6776 Peptide deformylase def 0.0021
6900 Peptide deformylase def 0.0021
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0021
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.002
3105 M-phase inducer phosphatase 2 CDC25B 0.0019
4343 Alpha-glucosidase aglA 0.0019
4192 DNA topoisomerase 2-beta TOP2B 0.0019
1836 Mitogen-activated protein kinase 10 MAPK10 0.0019
3168 Beta-lactamase OXA-1 bla 0.0018
4819 Hydrolase Not Available 0.0018
5249 Hydrolase Not Available 0.0018
5436 Hydrolase Not Available 0.0018
3230 Non-ATP-dependent L-selective hydantoinase lhyD 0.0018
3122 D-hydantoinase Not Available 0.0018
3145 D-hydantoinase hyuA 0.0018
2236 Casein kinase II subunit alpha CSNK2A1 0.0018
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0017
2840 Beta-lactamase IMP-1 Not Available 0.0017
3873 Prolyl endopeptidase PREP 0.0015
6928 Prolyl endopeptidase Not Available 0.0015
3237 Beta-lactamase OXA-2 bla 0.0015
3292 Alanine racemase, catabolic dadX 0.0015
3281 Isoaspartyl dipeptidase iadA 0.0015
4264 Alpha-L-fucosidase, putative TM_0306 0.0015
5304 UPF0166 protein TM_0021 TM_0021 0.0015
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0015
5293 Shikimate kinase 2 aroL 0.0015
5288 Shikimate kinase aroK 0.0015
5259 Transcriptional regulator ntrC1 0.0015
6699 Transcriptional regulator Cgl2612 0.0015
5287 Signaling protein Not Available 0.0015
5266 Activator of hgdC 0.0015
3199 Phosphopantetheine adenylyltransferase coaD 0.0015
3543 Phosphopantetheine adenylyltransferase coaD 0.0015
3567 Phosphopantetheine adenylyltransferase coaD 0.0015
5289 Phosphopantetheine adenylyltransferase coaD 0.0015
5283 D-alanine--D-alanine ligase B ddlB 0.0015
5299 D-alanine--D-alanine ligase ddl 0.0015
6598 D-alanine--D-alanine ligase ddl 0.0015
5276 Chromosomal replication initiator protein dnaA dnaA 0.0015
5292 Putative partitioning protein TT_C1605 0.0015
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0015
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0015
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0015
5291 Glycogen synthase 1 glgA1 0.0015
2874 Nitrogenase iron protein 1 nifH1 0.0015
4346 Polynucleotide kinase pseT 0.0015
5264 DNA replication protein REP 0.0015
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0015
5281 Plasmid segregation protein parM parM 0.0015
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0015
5308 Preprotein translocase secA 1 subunit secA1 0.0015
5285 Kinesin heavy chain KIF5B 0.0015
5315 Chaperone protein htpG htpG 0.0015
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0015
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0015
5284 Large T antigen Not Available 0.0015
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0015
5277 Preprotein translocase subunit secA secA 0.0015
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0015
5261 Phosphoribosylformylglycinamidine synthase purL 0.0015
2801 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase murE 0.0014
2983 Methylmalonyl-CoA carboxyltransferase 5S subunit Not Available 0.0014
4549 Endonuclease III HP_0602 0.0013
2646 Dihydroorotase pyrC 0.0013
2717 Folylpolyglutamate synthase fgs 0.0013
4774 NTPase P4 Not Available 0.0013
3470 Hypothetical protein MG245 homolog MPN_348 0.0013
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0013
4837 Cag-alfa cag-alfa 0.0013
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0013
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0013
4106 Guanylate kinase GUK1 0.0013
4516 Guanylate kinase gmk 0.0013
2270 Dephospho-CoA kinase coaE 0.0013
2284 Adenylate kinase adk 0.0013
2296 Adenylate kinase adk 0.0013
2311 Adenylate kinase adk 0.0013
2312 Adenylate kinase Not Available 0.0013
4839 DNA polymerase III subunit tau dnaX 0.0013
3426 Glutamine synthetase glnA 0.0013
3987 Glutamine synthetase GLUL 0.0013
413 Amidophosphoribosyltransferase PPAT 0.0013
2515 Amidophosphoribosyltransferase purF 0.0013
3714 Amidophosphoribosyltransferase purF 0.0013
3175 Glutamate--cysteine ligase gshA 0.0013
6277 Heat shock cognate 71 kDa protein HSPA8 0.0013
5189 Trimethylamine dehydrogenase tmd 0.0013
4838 PMS1 protein homolog 2 PMS2 0.0013
2340 Beta-lactamase PSE-2 bla 0.0012
2796 Parathion hydrolase opd 0.0012
6539 Parathion hydrolase opd 0.0012
2683 Mono-ADP-ribosyltransferase C3 C3 0.0012
894 Alanine racemase alr 0.0012
2453 Alanine racemase alr 0.0012
2390 Nonsecretory ribonuclease RNASE2 0.0012
2922 Glycerol kinase glpK 0.0012
5271 Focal adhesion kinase 1 PTK2 0.0012
3669 Ribokinase rbsK 0.0011
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0011
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0011
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0011
687 Tyrosine-protein phosphatase non-receptor type 1 PTPN1 0.0011
5300 Antigen peptide transporter 1 TAP1 0.0011
340 Apoptotic protease-activating factor 1 APAF1 0.0011
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.001
408 Riboflavin kinase RFK 0.001
2282 Protein recA recA 0.001
2315 Protein recA recA 0.001
2332 Protein recA recA 0.001
5263 Protein recA recA 0.001
2334 Dethiobiotin synthetase bioD 0.001
6555 Dethiobiotin synthetase bioD 0.001
2697 Uridine-cytidine kinase 2 UCK2 0.001
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.001
788 Creatine kinase M-type CKM 0.001
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.001
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.001
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.001
6395 Myosin-14 MYH14 0.0009
2091 Endoplasmin HSP90B1 0.0009
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0009
48 Pyridoxal kinase PDXK 0.0009
702 UMP-CMP kinase CMPK1 0.0009
3379 Kinesin-like protein KIF11 KIF11 0.0009
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0009
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0008
504 Mast/stem cell growth factor receptor KIT 0.0008
509 Thymidine kinase TK 0.0008
570 Thymidine kinase TK 0.0008
2559 Thymidine kinase TK 0.0008
3430 Thymidine kinase tdk 0.0008
3518 Thymidine kinase TK 0.0008
5301 Thymidine kinase tdk 0.0008
5771 Thymidine kinase ORF36 0.0008
7009 Thymidine kinase ORF36 0.0008
5294 Nucleoside diphosphate kinase A NME1 0.0008
4512 Cytochrome P450 3A4 CYP3A4 0.0007
5682 Ribonuclease pancreatic RNASE1 0.0007
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0007
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0007
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0007
4773 Deoxycytidine kinase DCK 0.0006
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