DT-Web

DB02026 - Furo[2,3d]Pyrimidine Antifolate


Identification
Name Furo[2,3d]Pyrimidine Antifolate
Accession Number DB02026 (EXPT00981)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 442.4253
Groups experimental
Monoisotopic Weight 442.160082466
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Dihydrofolate reductase
Name Dihydrofolate reductase
Gene Name Not Available
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.3356

Predictions


Id Partner name Gene Name Score
365 Dihydrofolate reductase DHFR 0.3356
2381 Dihydrofolate reductase DFR1 0.3356
2931 Dihydrofolate reductase folA 0.3356
3544 Dihydrofolate reductase folA 0.3356
3682 Dihydrofolate reductase folA 0.3356
6642 Dihydrofolate reductase folA 0.3356
6756 Dihydrofolate reductase dfrA 0.3356
4403 Protein iolS iolS 0.0081
5332 MtdA bifunctional protein mtdA 0.0081
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0081
5322 Oxidoreductase ydhF ydhF 0.0081
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0081
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0081
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0081
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0081
3778 NAD(P) transhydrogenase subunit beta pntB 0.0081
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0081
5330 General stress protein 69 yhdN 0.0081
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0081
989 L-xylulose reductase DCXR 0.0071
2636 Shikimate dehydrogenase aroE 0.0071
3515 Shikimate dehydrogenase aroE 0.0071
4582 Putative pteridine reductase 2 ptr2 0.0071
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.0071
3446 NADP-dependent alcohol dehydrogenase adh 0.0071
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0071
5328 Prostaglandin F synthase Tb11.02.2310 0.0071
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0071
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0071
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0071
729 GDP-L-fucose synthetase TSTA3 0.0071
3463 GDP-L-fucose synthetase fcl 0.0071
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0071
2286 Isocitrate dehydrogenase [NADP] icd 0.0071
2302 Isocitrate dehydrogenase [NADP] icd 0.0071
2771 Isocitrate dehydrogenase [NADP] icd 0.0071
5073 Ferredoxin--NADP reductase petH 0.0071
5076 Ferredoxin--NADP reductase fpr 0.0071
5119 Ferredoxin--NADP reductase petH 0.0071
5121 Ferredoxin--NADP reductase fpr 0.0071
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0071
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.0065
3062 Aspartate-semialdehyde dehydrogenase asd 0.0065
4531 Putative ketoacyl reductase actIII 0.0065
6297 Prostaglandin reductase 1 PTGR1 0.0065
2675 Pteridine reductase 1 PTR1 0.0061
1124 Sepiapterin reductase SPR 0.0061
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0061
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0061
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0059
666 NADP-dependent malic enzyme ME1 0.0059
646 Malate dehydrogenase, cytoplasmic MDH1 0.0058
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0058
2159 Quinone oxidoreductase CRYZ 0.0057
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0051
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.005
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.005
654 Flavin reductase BLVRB 0.005
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0046
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0046
444 Alcohol dehydrogenase 1B ADH1B 0.0045
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0044
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0044
76 Nitric-oxide synthase, brain NOS1 0.0041
822 Aldose reductase AKR1B1 0.004
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0038
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0038
4120 NADPH--cytochrome P450 reductase POR 0.0036
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