DT-Web

DB02015 - Dihydrofolic Acid


Identification
Name Dihydrofolic Acid
Accession Number DB02015 (EXPT01190)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 443.4133
Groups experimental
Monoisotopic Weight 443.155331439
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Dihydrofolate reductase
Name Dihydrofolate reductase
Gene Name folA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.0108
Putative pteridine reductase 2
Name Putative pteridine reductase 2
Gene Name ptr2
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.6792

Predictions


Id Partner name Gene Name Score
3193 Serine hydroxymethyltransferase glyA 0.1563
3342 Serine hydroxymethyltransferase glyA 0.1563
2636 Shikimate dehydrogenase aroE 0.1199
3515 Shikimate dehydrogenase aroE 0.1199
3627 UPF0190 protein yedY yedY 0.0599
1392 Catenin beta-1 CTNNB1 0.0599
3352 Structural polyprotein Not Available 0.0598
3628 Structural polyprotein Not Available 0.0598
4892 Structural polyprotein Not Available 0.0598
5682 Ribonuclease pancreatic RNASE1 0.0598
315 Arginase-1 ARG1 0.0353
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0231
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0231
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0231
5330 General stress protein 69 yhdN 0.0231
5322 Oxidoreductase ydhF ydhF 0.0231
5332 MtdA bifunctional protein mtdA 0.0231
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0231
4403 Protein iolS iolS 0.0231
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0231
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0231
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0231
3778 NAD(P) transhydrogenase subunit beta pntB 0.0231
357 Carbonic anhydrase 2 CA2 0.0221
989 L-xylulose reductase DCXR 0.0201
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0201
5328 Prostaglandin F synthase Tb11.02.2310 0.0201
3446 NADP-dependent alcohol dehydrogenase adh 0.0201
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.0201
729 GDP-L-fucose synthetase TSTA3 0.0201
3463 GDP-L-fucose synthetase fcl 0.0201
5073 Ferredoxin--NADP reductase petH 0.0201
5076 Ferredoxin--NADP reductase fpr 0.0201
5119 Ferredoxin--NADP reductase petH 0.0201
5121 Ferredoxin--NADP reductase fpr 0.0201
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0201
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0201
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0201
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0201
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0201
2286 Isocitrate dehydrogenase [NADP] icd 0.0201
2302 Isocitrate dehydrogenase [NADP] icd 0.0201
2771 Isocitrate dehydrogenase [NADP] icd 0.0201
4531 Putative ketoacyl reductase actIII 0.0186
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.0185
3062 Aspartate-semialdehyde dehydrogenase asd 0.0185
6297 Prostaglandin reductase 1 PTGR1 0.0185
2675 Pteridine reductase 1 PTR1 0.0176
1124 Sepiapterin reductase SPR 0.0175
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0175
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0175
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0173
666 NADP-dependent malic enzyme ME1 0.0172
646 Malate dehydrogenase, cytoplasmic MDH1 0.0168
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0168
2159 Quinone oxidoreductase CRYZ 0.0161
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0147
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0146
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0145
654 Flavin reductase BLVRB 0.0142
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0133
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0131
444 Alcohol dehydrogenase 1B ADH1B 0.013
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0125
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0125
76 Nitric-oxide synthase, brain NOS1 0.0117
822 Aldose reductase AKR1B1 0.0115
365 Dihydrofolate reductase DHFR 0.0108
2381 Dihydrofolate reductase DFR1 0.0108
2833 Dihydrofolate reductase Not Available 0.0108
2931 Dihydrofolate reductase folA 0.0108
3544 Dihydrofolate reductase folA 0.0108
6642 Dihydrofolate reductase folA 0.0108
6756 Dihydrofolate reductase dfrA 0.0108
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0108
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0108
4120 NADPH--cytochrome P450 reductase POR 0.0103
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