DT-Web

DB02001 - 5-(4-Morpholin-4-Yl-Phenylsulfanyl)-2,4-Quinazolinediamine


Identification
Name 5-(4-Morpholin-4-Yl-Phenylsulfanyl)-2,4-Quinazolinediamine
Accession Number DB02001 (EXPT03102)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 353.441
Groups experimental
Monoisotopic Weight 353.131030945
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Dihydrofolate reductase
Name Dihydrofolate reductase
Gene Name DFR1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.5267
Dihydrofolate reductase-like protein 1
Name Dihydrofolate reductase-like protein 1
Gene Name DHFRL1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.9668

Predictions


Id Partner name Gene Name Score
365 Dihydrofolate reductase DHFR 1.5267
2833 Dihydrofolate reductase Not Available 1.5267
2931 Dihydrofolate reductase folA 1.5267
3544 Dihydrofolate reductase folA 1.5267
3682 Dihydrofolate reductase folA 1.5267
6642 Dihydrofolate reductase folA 1.5267
6756 Dihydrofolate reductase dfrA 1.5267
5440 UPF0067 protein yebR yebR 0.01
3781 Thiol:disulfide interchange protein dsbC precursor dsbC 0.01
4705 Manganese catalase Not Available 0.01
5449 Hypothetical gliding protein mglB 0.01
5448 Ribonuclease Z rnz 0.01
5443 UPF0189 protein ymdB ymdB 0.01
5446 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase HI_1679 0.01
5439 33 kDa chaperonin hslO 0.01
332 Beta-lactamase blaZ 0.01
2478 Beta-lactamase ampC 0.01
2613 Beta-lactamase ampC 0.01
2635 Beta-lactamase ampC 0.01
2700 Beta-lactamase penP 0.01
5445 Beta-lactamase blaB 0.01
6019 Beta-lactamase SHV-7 0.01
6701 Beta-lactamase cphA 0.01
2720 Copper-containing nitrite reductase nirK 0.01
5447 Lethal(3)malignant brain tumor-like protein L3MBTL1 0.01
5454 Internalin-A inlA 0.01
2714 Chorismate mutase aroH 0.0087
4611 Chorismate mutase aroG 0.0087
4771 Dissimilatory copper-containing nitrite reductase nir 0.0087
3356 Diaminopimelate decarboxylase lysA 0.0087
3274 Hydroxylamine reductase hcp 0.0087
4804 Hydroxylamine reductase hcp 0.0087
4498 Ornithine cyclodeaminase PP3533 0.0087
5450 Prolyl endopeptidase Pep pep 0.0087
3399 Limonene-1,2-epoxide hydrolase limA 0.008
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.008
3462 Tyrosine-protein kinase transforming protein Abl ABL 0.008
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.008
5180 L(+)-mandelate dehydrogenase mdlB 0.0076
3500 Putative family 31 glucosidase yicI yicI 0.0076
1615 Chymase CMA1 0.0072
4608 Putative cytochrome P450 SCO1207 0.0072
4963 Putative cytochrome P450 SCO2884 0.0072
6254 Putative cytochrome P450 SCO6998 0.0072
597 Dihydropteridine reductase QDPR 0.007
3480 Mannan endo-1,4-beta-mannosidase manA 0.007
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.007
577 Argininosuccinate lyase ASL 0.0069
287 Beta-1,4-galactosyltransferase 1 B4GALT1 0.0065
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0054
904 Glutathione S-transferase P GSTP1 0.0045
474 Acetylcholinesterase ACHE 0.0039
3923 Cholinesterase BCHE 0.0032
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