DT-Web

DB01962 - Phosphonotyrosine


Identification
Name Phosphonotyrosine
Accession Number DB01962 (EXPT02687)
Type small molecule
Description An amino acid that occurs in endogenous proteins. Tyrosine phosphorylation and dephosphorylation plays a role in cellular signal transduction and possibly in cell growth control and carcinogenesis. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 261.1684
Groups experimental
Monoisotopic Weight 261.040223633
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Tyrosine-protein kinase HCK
Name Tyrosine-protein kinase HCK
Gene Name HCK
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.585
Proto-oncogene tyrosine-protein kinase Src
Name Proto-oncogene tyrosine-protein kinase Src
Gene Name SRC
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.7434
Mast/stem cell growth factor receptor
Name Mast/stem cell growth factor receptor
Gene Name KIT
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.2551

Predictions


Id Partner name Gene Name Score
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.2081
6824 Tyrosine-protein kinase Lyn LYN 0.0952
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0812
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0623
1588 Multidrug resistance protein 1 ABCB1 0.0525
228 Beta platelet-derived growth factor receptor PDGFRB 0.0473
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0469
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0461
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0431
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0428
4512 Cytochrome P450 3A4 CYP3A4 0.0401
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0353
407 Vascular endothelial growth factor receptor 2 KDR 0.0352
26 Vascular endothelial growth factor receptor 3 FLT4 0.034
32 Vascular endothelial growth factor receptor 1 FLT1 0.0329
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0296
6837 Serine/threonine-protein kinase 17B STK17B 0.0296
165 FL cytokine receptor FLT3 0.0285
6782 Ribosomal protein S6 kinase alpha-1 RPS6KA1 0.0273
4924 Cytochrome P450 2C8 CYP2C8 0.0271
2240 Cell division protein kinase 2 CDK2 0.0268
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0257
3856 Fibroblast growth factor receptor 3 FGFR3 0.024
6599 HTH-type transcriptional regulator ttgR ttgR 0.0237
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0225
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0222
844 Epidermal growth factor receptor EGFR 0.0221
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0219
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0214
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0214
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0214
6460 Casein kinase I isoform gamma-3 CSNK1G3 0.0207
936 Ephrin type-A receptor 2 EPHA2 0.0201
4118 Cytochrome P450 3A5 CYP3A5 0.0188
1540 Mitogen-activated protein kinase 14 MAPK14 0.0187
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0187
5787 Angiopoietin-1 receptor TEK 0.0186
4119 Cytochrome P450 2D6 CYP2D6 0.0181
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0176
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0169
823 Fibroblast growth factor receptor 2 FGFR2 0.0168
489 Monocarboxylate transporter 2 SLC16A7 0.0165
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0158
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0144
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.014
2216 Fibroblast growth factor receptor 4 FGFR4 0.0138
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0136
1618 High affinity nerve growth factor receptor NTRK1 0.0136
1063 Signal transducer and activator of transcription 5B STAT5B 0.0135
4757 Cytochrome P450 2C9 CYP2C9 0.0135
4200 Cytochrome P450 1A2 CYP1A2 0.0133
6030 Cytochrome P450 2B6 CYP2B6 0.013
738 Monocarboxylate transporter 1 SLC16A1 0.0125
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0124
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0118
484 Tyrosine-protein kinase ABL2 ABL2 0.0117
4609 U1 small nuclear ribonucleoprotein A SNRPA 0.0117
6107 Cytochrome P450 3A7 CYP3A7 0.0104
4563 Acetyl transferase rimL 0.0102
2750 Aspartate 1-decarboxylase panD 0.0102
5798 Mitogen-activated protein kinase 11 MAPK11 0.0096
2164 Multidrug resistance-associated protein 4 ABCC4 0.0095
3490 Sigma factor sigB regulation protein rsbQ rsbQ 0.0094
862 Multidrug resistance-associated protein 1 ABCC1 0.0094
4600 Malonamidase E2 Not Available 0.0088
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0087
4608 Putative cytochrome P450 SCO1207 0.0085
4963 Putative cytochrome P450 SCO2884 0.0085
6254 Putative cytochrome P450 SCO6998 0.0085
760 Fibroblast growth factor 1 FGF1 0.0082
1864 RET proto-oncogene RET 0.0082
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0082
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0082
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0082
6142 Solute carrier family 22 member 8 SLC22A8 0.008
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.008
6016 Cytochrome P450 2C19 CYP2C19 0.0078
1898 Cytochrome P450 1B1 CYP1B1 0.0066
776 Bile salt export pump ABCB11 0.0057
6024 Cytochrome P450 1A1 CYP1A1 0.0054
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.005
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0038
6144 Solute carrier family 22 member 2 SLC22A2 0.0034
6145 Solute carrier family 22 member 1 SLC22A1 0.0033
20 Prostaglandin G/H synthase 1 PTGS1 0.0032
587 Serum albumin ALB 0.003
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0027
5304 UPF0166 protein TM_0021 TM_0021 0.0025
5293 Shikimate kinase 2 aroL 0.0025
5266 Activator of hgdC 0.0025
5287 Signaling protein Not Available 0.0025
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0025
5292 Putative partitioning protein TT_C1605 0.0025
3199 Phosphopantetheine adenylyltransferase coaD 0.0025
3543 Phosphopantetheine adenylyltransferase coaD 0.0025
3567 Phosphopantetheine adenylyltransferase coaD 0.0025
5289 Phosphopantetheine adenylyltransferase coaD 0.0025
5281 Plasmid segregation protein parM parM 0.0025
2874 Nitrogenase iron protein 1 nifH1 0.0025
4346 Polynucleotide kinase pseT 0.0025
5283 D-alanine--D-alanine ligase B ddlB 0.0025
5288 Shikimate kinase aroK 0.0025
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0025
5299 D-alanine--D-alanine ligase ddl 0.0025
6598 D-alanine--D-alanine ligase ddl 0.0025
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0025
5276 Chromosomal replication initiator protein dnaA dnaA 0.0025
5315 Chaperone protein htpG htpG 0.0025
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0025
5259 Transcriptional regulator ntrC1 0.0025
6699 Transcriptional regulator Cgl2612 0.0025
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0025
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0025
5284 Large T antigen Not Available 0.0025
5291 Glycogen synthase 1 glgA1 0.0025
5264 DNA replication protein REP 0.0025
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0025
5285 Kinesin heavy chain KIF5B 0.0025
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0025
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0025
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0025
5261 Phosphoribosylformylglycinamidine synthase purL 0.0025
5277 Preprotein translocase subunit secA secA 0.0025
5308 Preprotein translocase secA 1 subunit secA1 0.0025
2697 Uridine-cytidine kinase 2 UCK2 0.0024
3470 Hypothetical protein MG245 homolog MPN_348 0.0021
6277 Heat shock cognate 71 kDa protein HSPA8 0.0021
5189 Trimethylamine dehydrogenase tmd 0.002
4106 Guanylate kinase GUK1 0.002
4516 Guanylate kinase gmk 0.002
413 Amidophosphoribosyltransferase PPAT 0.002
2515 Amidophosphoribosyltransferase purF 0.002
3714 Amidophosphoribosyltransferase purF 0.002
4837 Cag-alfa cag-alfa 0.002
5646 Galactokinase GALK1 0.002
3390 Aminoglycoside 3'-phosphotransferase aphA 0.002
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.002
5302 TrwB trwB 0.002
4774 NTPase P4 Not Available 0.002
4839 DNA polymerase III subunit tau dnaX 0.002
5265 FtsH ftsH 0.002
4838 PMS1 protein homolog 2 PMS2 0.002
2270 Dephospho-CoA kinase coaE 0.002
2284 Adenylate kinase adk 0.002
2296 Adenylate kinase adk 0.002
2311 Adenylate kinase adk 0.002
2312 Adenylate kinase Not Available 0.002
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.002
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.002
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.002
3426 Glutamine synthetase glnA 0.002
3987 Glutamine synthetase GLUL 0.002
3175 Glutamate--cysteine ligase gshA 0.002
2683 Mono-ADP-ribosyltransferase C3 C3 0.0019
5271 Focal adhesion kinase 1 PTK2 0.0018
5300 Antigen peptide transporter 1 TAP1 0.0018
340 Apoptotic protease-activating factor 1 APAF1 0.0018
2390 Nonsecretory ribonuclease RNASE2 0.0018
5312 Kinesin-like protein KIF1A KIF1A 0.0018
2922 Glycerol kinase glpK 0.0018
5682 Ribonuclease pancreatic RNASE1 0.0017
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0017
408 Riboflavin kinase RFK 0.0017
2615 Chemotaxis protein cheA cheA 0.0017
2371 Pantothenate kinase coaA 0.0017
2282 Protein recA recA 0.0017
2315 Protein recA recA 0.0017
2332 Protein recA recA 0.0017
5263 Protein recA recA 0.0017
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0017
2892 Acetylglutamate kinase argB 0.0017
3550 Acetylglutamate kinase argB 0.0017
3669 Ribokinase rbsK 0.0017
1881 Hexokinase-1 HK1 0.0017
825 Arsenical pump-driving ATPase ASNA1 0.0017
3435 Arsenical pump-driving ATPase arsA 0.0017
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0017
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0016
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0016
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0016
2727 S-adenosylmethionine synthetase metK 0.0016
788 Creatine kinase M-type CKM 0.0016
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0015
2334 Dethiobiotin synthetase bioD 0.0015
6555 Dethiobiotin synthetase bioD 0.0015
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0015
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0015
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0015
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0015
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0015
48 Pyridoxal kinase PDXK 0.0015
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0014
6395 Myosin-14 MYH14 0.0014
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0014
2091 Endoplasmin HSP90B1 0.0014
702 UMP-CMP kinase CMPK1 0.0014
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0014
2251 Thymidylate kinase tmk 0.0014
2254 Thymidylate kinase DTYMK 0.0014
3522 Thymidylate kinase tmk 0.0014
1422 Serine/threonine-protein kinase 6 AURKA 0.0014
207 Glutathione synthetase GSS 0.0014
5269 Glutathione synthetase gshB 0.0014
3379 Kinesin-like protein KIF11 KIF11 0.0013
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0013
3822 Actin, alpha skeletal muscle ACTA1 0.0013
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0013
2300 Lysozyme E 0.0013
3633 Lysozyme R 0.0013
5597 Lysozyme 17 0.0013
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0013
5591 Complement component C8 gamma chain C8G 0.0013
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0013
5582 Regulator of transcription; stringent starvation protein A sspA 0.0013
2838 Ribose-5-phosphate isomerase A rpiA 0.0013
2952 Ribose-5-phosphate isomerase A rpiA 0.0013
5595 Ribose-5-phosphate isomerase A rpiA 0.0013
4238 50S ribosomal protein L4 rplD 0.0013
5578 50S ribosomal protein L4 rplD 0.0013
6173 50S ribosomal protein L4 rplD 0.0013
6219 50S ribosomal protein L4 rplD 0.0013
4695 UPF0124 protein yfiH yfiH 0.0013
5590 N utilization substance protein B homolog nusB 0.0013
5588 Cell division protein FtsY TM_0570 0.0013
4375 Glutamine synthetase 1 glnA1 0.0013
5587 Iron(III)-binding periplasmic protein fbpA 0.0013
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0013
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0013
5593 Transferase Not Available 0.0013
5581 Beta-fructosidase bfrA 0.0013
5060 Intron-associated endonuclease 1 ITEVIR 0.0013
5575 Short tail fiber protein 12 0.0013
5600 Pyruvate decarboxylase pdc 0.0013
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0013
5580 Hexon protein PII 0.0013
5574 Invasin YPTB1668 0.0013
509 Thymidine kinase TK 0.0012
570 Thymidine kinase TK 0.0012
2559 Thymidine kinase TK 0.0012
3430 Thymidine kinase tdk 0.0012
3518 Thymidine kinase TK 0.0012
5301 Thymidine kinase tdk 0.0012
5771 Thymidine kinase ORF36 0.0012
7009 Thymidine kinase ORF36 0.0012
5294 Nucleoside diphosphate kinase A NME1 0.0012
1721 Glycogen synthase kinase-3 beta GSK3B 0.0012
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0011
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0011
4992 Cytochrome c peroxidase Not Available 0.0011
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0011
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0011
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0011
4533 Glyoxalase family protein BC_1747 0.0011
3132 Tryptophan synthase alpha chain trpA 0.0011
6568 Tryptophan synthase alpha chain trpA 0.0011
5328 Prostaglandin F synthase Tb11.02.2310 0.0011
3729 Citrate synthase gltA 0.0011
4575 Citrate synthase cit 0.0011
4580 Citrate synthase gltA 0.0011
5006 RNASE4 protein RNASE4 0.0011
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0011
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0011
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0011
2555 Pol polyprotein pol 0.0011
3242 Pol polyprotein gag-pol 0.0011
3471 Pol polyprotein gag-pro-pol 0.0011
5256 Pol polyprotein pol 0.0011
6469 Pol polyprotein gag-pol 0.0011
6565 Pol polyprotein Not Available 0.0011
4773 Deoxycytidine kinase DCK 0.0011
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.001
2603 Beta-lactamase II blm 0.001
3583 6-phosphogluconolactonase pgl 0.001
2149 Angiogenin ANG 0.001
2521 Cell division protein ftsZ ftsZ 0.001
3301 Cell division protein ftsZ ftsZ 0.001
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.001
2286 Isocitrate dehydrogenase [NADP] icd 0.001
2302 Isocitrate dehydrogenase [NADP] icd 0.001
2771 Isocitrate dehydrogenase [NADP] icd 0.001
3486 Fumarate hydratase class II fumC 0.001
2942 Sialidase nanH 0.001
3546 Sialidase nedA 0.001
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0009
857 Malate dehydrogenase, mitochondrial MDH2 0.0009
1123 Eosinophil cationic protein RNASE3 0.0009
332 Beta-lactamase blaZ 0.0009
2478 Beta-lactamase ampC 0.0009
2613 Beta-lactamase ampC 0.0009
2635 Beta-lactamase ampC 0.0009
2700 Beta-lactamase penP 0.0009
5445 Beta-lactamase blaB 0.0009
6019 Beta-lactamase SHV-7 0.0009
6701 Beta-lactamase cphA 0.0009
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0009
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0009
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0009
2452 Tryptophanyl-tRNA synthetase trpS 0.0009
5579 Carboxypeptidase B CPB1 0.0008
3384 Macrophage migration inhibitory factor MIF 0.0008
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0008
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0008
411 Glycine N-methyltransferase GNMT 0.0008
128 Adenine phosphoribosyltransferase APRT 0.0007
822 Aldose reductase AKR1B1 0.0006
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0006
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