DT-Web

DB01955 - 1,4-Butanediol


Identification
Name 1,4-Butanediol
Accession Number DB01955 (EXPT00771)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 90.121
Groups experimental
Monoisotopic Weight 90.068079564
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
Name Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
Gene Name MAN1B1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.2509
Phospholipase A2, membrane associated
Name Phospholipase A2, membrane associated
Gene Name PLA2G2A
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.5789
Group IIE secretory phospholipase A2
Name Group IIE secretory phospholipase A2
Gene Name PLA2G2E
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.4842
Ribosomal small subunit pseudouridine synthase A
Name Ribosomal small subunit pseudouridine synthase A
Gene Name rsuA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9139
Penicillin-insensitive murein endopeptidase precursor
Name Penicillin-insensitive murein endopeptidase precursor
Gene Name mepA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9139

Predictions


Id Partner name Gene Name Score
3706 Ribosomal small subunit pseudouridine synthase A rsuA 0.9139
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.2069
6500 Phospholipase A2 PLA2G1B 0.1471
1439 Lactotransferrin LTF 0.119
5983 Alpha-mannosidase 2 MAN2A1 0.1008
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0712
2508 Cyclomaltodextrin glucanotransferase cgt 0.0712
2523 Cyclomaltodextrin glucanotransferase cgt 0.0712
3207 Cyclomaltodextrin glucanotransferase amyA 0.0712
2245 Xylose isomerase xylA 0.068
2253 Xylose isomerase xylA 0.068
2260 Xylose isomerase xylA 0.068
2431 Xylose isomerase xylA 0.068
3289 Beta-glucosidase A bglA 0.062
3298 Beta-glucosidase A bglA 0.062
2421 Signal peptidase I lepB 0.0522
6269 S-phase kinase-associated protein 1 SKP1 0.0488
708 Alpha-tocopherol transfer protein TTPA 0.0483
2537 Aromatic-amino-acid aminotransferase tyrB 0.0417
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0416
2249 Aspartate aminotransferase aspC 0.0387
2671 Aspartate aminotransferase aspC 0.0387
5490 Aspartate aminotransferase Not Available 0.0387
290 Prostaglandin G/H synthase 2 PTGS2 0.0383
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.029
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.029
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.029
587 Serum albumin ALB 0.0228
1729 Solute carrier family 22 member 6 SLC22A6 0.0221
4165 P2Y purinoceptor 2 P2RY2 0.0216
275 Arachidonate 5-lipoxygenase ALOX5 0.0201
2654 Complement control protein C3L 0.0174
430 Follicle-stimulating hormone receptor FSHR 0.0164
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0159
1757 Myeloperoxidase MPO 0.0159
5455 Arylsulfatase A ARSA 0.0151
814 Ryanodine receptor 1 RYR1 0.0137
482 Glycine receptor subunit alpha-1 GLRA1 0.0126
723 Cytosolic phospholipase A2 PLA2G4A 0.0109
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0105
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0104
4757 Cytochrome P450 2C9 CYP2C9 0.01
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0098
3116 Bacterioferritin bfr 0.0087
4906 Bacterioferritin bfr 0.0087
4965 Bacterioferritin bfr 0.0087
3238 Multidrug resistance protein mexA mexA 0.0087
3173 Enolase eno 0.0087
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0087
3709 Glycerol uptake facilitator protein glpF 0.0087
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0087
3393 TGF-beta receptor type-2 TGFBR2 0.0087
54 Prothrombin F2 0.0086
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0083
2852 DNA mismatch repair protein mutL mutL 0.0076
1072 Granzyme B GZMB 0.0071
4878 Glycoprotein hormones alpha chain CGA 0.0071
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0071
4856 CD209 antigen CD209 0.0071
4877 Beta-mannanase man 0.0071
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0071
4880 Membrane cofactor protein CD46 0.0071
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0071
4889 Ig epsilon chain C region IGHE 0.0071
4189 Alpha-galactosidase A GLA 0.0071
4869 Major capsid protein A430L 0.0071
4852 Reticulon-4 receptor RTN4R 0.0071
757 Fusion glycoprotein F0 F 0.0071
4875 Fusion glycoprotein F0 F 0.0071
4721 Beta-1,4-mannanase manA 0.0071
4850 Beta-2-glycoprotein 1 APOH 0.0071
1354 Beta-glucuronidase GUSB 0.0071
4845 ADAM 33 ADAM33 0.0071
442 Envelope glycoprotein gp41 0.0071
4859 Envelope glycoprotein env 0.0071
3352 Structural polyprotein Not Available 0.0071
3628 Structural polyprotein Not Available 0.0071
4892 Structural polyprotein Not Available 0.0071
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0071
6459 Glycodelin PAEP 0.007
3221 Cytochrome c4 cc4 0.0067
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0067
3191 Histidinol dehydrogenase hisD 0.0067
20 Prostaglandin G/H synthase 1 PTGS1 0.0065
4604 Liver carboxylesterase 1 CES1 0.0064
4311 tRNA TRDMT1 0.0062
4325 tRNA trmD 0.0062
4328 tRNA trmD 0.0062
793 T-cell surface antigen CD2 CD2 0.0062
1184 Interferon beta IFNB1 0.0062
4890 Hemagglutinin HA 0.0062
6566 Hemagglutinin Not Available 0.0062
6858 Inactive carboxylesterase 4 CES1P1 0.0062
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0062
1379 Interleukin-12 subunit beta IL12B 0.0062
4861 Interleukin-6 receptor alpha chain IL6R 0.0062
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0062
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0062
3837 Cytokine receptor common beta chain CSF2RB 0.0062
4692 A/G-specific adenine glycosylase mutY 0.0061
740 Argininosuccinate synthase ASS1 0.0061
865 Argininosuccinate synthase ASS1 0.0061
2680 Argininosuccinate synthase argG 0.0061
3194 Argininosuccinate synthase argG 0.0061
2802 Endoglucanase G celCCG 0.0061
6316 ADP-ribosylation factor 1 ARF1 0.0059
3444 Cyanovirin-N Not Available 0.0057
1859 Prostatic acid phosphatase ACPP 0.0057
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0057
3140 Hemagglutinin-neuraminidase HN 0.0057
3609 Hemagglutinin-neuraminidase HN 0.0057
2297 Genome polyprotein Not Available 0.0057
2322 Genome polyprotein Not Available 0.0057
2694 Genome polyprotein Not Available 0.0057
2719 Genome polyprotein Not Available 0.0057
2860 Genome polyprotein Not Available 0.0057
2928 Genome polyprotein Not Available 0.0057
3160 Genome polyprotein Not Available 0.0057
3260 Genome polyprotein Not Available 0.0057
4783 Genome polyprotein Not Available 0.0057
5726 Genome polyprotein Not Available 0.0057
5779 Genome polyprotein Not Available 0.0057
5867 Genome polyprotein Not Available 0.0057
6253 Genome polyprotein Not Available 0.0057
6301 Genome polyprotein Not Available 0.0057
6380 Genome polyprotein Not Available 0.0057
6381 Genome polyprotein Not Available 0.0057
6437 Genome polyprotein Not Available 0.0057
6520 Genome polyprotein Not Available 0.0057
6521 Genome polyprotein Not Available 0.0057
6652 Genome polyprotein Not Available 0.0057
6734 Genome polyprotein Not Available 0.0057
6735 Genome polyprotein Not Available 0.0057
6736 Genome polyprotein Not Available 0.0057
6737 Genome polyprotein Not Available 0.0057
6738 Genome polyprotein Not Available 0.0057
6739 Genome polyprotein Not Available 0.0057
6744 Genome polyprotein Not Available 0.0057
6748 Genome polyprotein Not Available 0.0057
6894 Genome polyprotein Not Available 0.0057
6898 Genome polyprotein Not Available 0.0057
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0057
6042 Prostaglandin reductase 2 PTGR2 0.0055
1588 Multidrug resistance protein 1 ABCB1 0.0055
4666 Fucose-binding lectin PA-IIL lecB 0.0054
2372 Bifunctional tail protein 9 0.0054
4787 Envelope glycoprotein gp160 env 0.0054
4820 Envelope glycoprotein gp160 env 0.0054
5727 Envelope glycoprotein gp160 env 0.0054
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0054
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0052
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0052
554 Low-density lipoprotein receptor LDLR 0.0052
852 Heparin cofactor 2 SERPIND1 0.0051
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0051
1024 Solute carrier family 22 member 11 SLC22A11 0.005
3480 Mannan endo-1,4-beta-mannosidase manA 0.005
64 Neuraminidase NA 0.005
641 Neuraminidase NA 0.005
2676 Neuraminidase NA 0.005
3026 Neuraminidase NA 0.005
3519 Neuraminidase NA 0.005
6007 Neuraminidase NA 0.005
2164 Multidrug resistance-associated protein 4 ABCC4 0.0049
444 Alcohol dehydrogenase 1B ADH1B 0.0049
862 Multidrug resistance-associated protein 1 ABCC1 0.0048
595 Fibrinogen alpha chain FGA 0.0047
6043 Putative G-protein coupled receptor 44 GPR44 0.0047
1243 Cathepsin D CTSD 0.0047
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0046
2430 Chondroitinase B cslB 0.0046
958 Insulin-like growth factor 1 receptor IGF1R 0.0046
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0045
6307 Ig gamma-2 chain C region IGHG2 0.0045
2581 Chondroitinase AC cslA 0.0045
6142 Solute carrier family 22 member 8 SLC22A8 0.0045
1313 Lactoylglutathione lyase GLO1 0.0045
6847 Lactase-phlorizin hydrolase LCT 0.0044
6013 Cytochrome P450 2E1 CYP2E1 0.0043
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0042
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0041
904 Glutathione S-transferase P GSTP1 0.004
2207 Rhodopsin RHO 0.004
3814 Complement C1r subcomponent C1R 0.0039
309 Antithrombin-III SERPINC1 0.0039
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0039
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0037
4785 Ig gamma-1 chain C region IGHG1 0.0037
76 Nitric-oxide synthase, brain NOS1 0.0036
6016 Cytochrome P450 2C19 CYP2C19 0.0035
6141 Sodium/bile acid cotransporter SLC10A1 0.0033
952 Dipeptidyl peptidase 4 DPP4 0.0032
6137 Multidrug resistance-associated protein 6 ABCC6 0.0031
373 Transthyretin TTR 0.0031
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0031
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0029
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0029
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0027
6106 Cytochrome P450 2C18 CYP2C18 0.0026
6143 Solute carrier family 22 member 7 SLC22A7 0.0025
3923 Cholinesterase BCHE 0.0024
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0024
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0022
6024 Cytochrome P450 1A1 CYP1A1 0.002
6030 Cytochrome P450 2B6 CYP2B6 0.002
4924 Cytochrome P450 2C8 CYP2C8 0.0018
4200 Cytochrome P450 1A2 CYP1A2 0.0017
4512 Cytochrome P450 3A4 CYP3A4 0.0015
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