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DB01941 - 6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Cyclopropyl]Pyridine-3-Carboxylic Acid


Identification
Name 6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Cyclopropyl]Pyridine-3-Carboxylic Acid
Accession Number DB01941 (EXPT02021)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 363.4926
Groups experimental
Monoisotopic Weight 363.219829177
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Retinoic acid receptor RXR-beta
Name Retinoic acid receptor RXR-beta
Gene Name RXRB
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.4099

Predictions


Id Partner name Gene Name Score
6283 Oxysterols receptor LXR-alpha NR1H3 0.1452
780 Retinoic acid receptor RXR-gamma RXRG 0.0993
459 Retinoic acid receptor RXR-alpha RXRA 0.0854
229 Retinoic acid receptor beta RARB 0.0852
730 Retinoic acid receptor alpha RARA 0.0838
162 Retinoic acid receptor gamma-1 RARG 0.0828
6241 Nuclear receptor coactivator 2 NCOA2 0.0507
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0363
5934 Cytochrome P450 26A1 CYP26A1 0.029
2907 Oxysterols receptor LXR-beta NR1H2 0.0242
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0208
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0176
6228 Nuclear receptor coactivator 1 NCOA1 0.0172
331 Retinol-binding protein I, cellular RBP1 0.0171
4924 Cytochrome P450 2C8 CYP2C8 0.0143
4757 Cytochrome P450 2C9 CYP2C9 0.0132
4512 Cytochrome P450 3A4 CYP3A4 0.0116
719 Retinoic acid receptor responder protein 1 RARRES1 0.0089
770 Retinoic acid-induced protein 3 GPRC5A 0.0089
3811 Cytochrome P450 19A1 CYP19A1 0.0088
84 Nuclear receptor 0B1 NR0B1 0.0072
569 Retinal dehydrogenase 2 ALDH1A2 0.0071
587 Serum albumin ALB 0.007
611 Retinal dehydrogenase 1 ALDH1A1 0.0068
4200 Cytochrome P450 1A2 CYP1A2 0.0054
1588 Multidrug resistance protein 1 ABCB1 0.0053
468 Cytochrome P450 4A11 CYP4A11 0.005
6106 Cytochrome P450 2C18 CYP2C18 0.0042
5718 Cytochrome P450 2A6 CYP2A6 0.0034
6024 Cytochrome P450 1A1 CYP1A1 0.0033
6030 Cytochrome P450 2B6 CYP2B6 0.0031
6107 Cytochrome P450 3A7 CYP3A7 0.0031
4118 Cytochrome P450 3A5 CYP3A5 0.0029
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