DT-Web

DB01931 - Dcka, 5,7-Dichlorokynurenic Acid


Identification
Name Dcka, 5,7-Dichlorokynurenic Acid
Accession Number DB01931 (EXPT01212)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 258.058
Groups experimental
Monoisotopic Weight 256.964648445
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Glutamate [NMDA] receptor subunit zeta-1
Name Glutamate [NMDA] receptor subunit zeta-1
Gene Name GRIN1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.5949

Predictions


Id Partner name Gene Name Score
5469 Head decoration protein shp 0.0562
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0448
824 Sodium-dependent serotonin transporter SLC6A4 0.0345
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.034
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0327
482 Glycine receptor subunit alpha-1 GLRA1 0.0265
6070 Nischarin NISCH 0.0261
6151 Monocarboxylate transporter 10 SLC16A10 0.0249
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0198
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0175
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.017
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0161
6030 Cytochrome P450 2B6 CYP2B6 0.0152
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0145
378 Alpha-2C adrenergic receptor ADRA2C 0.0139
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0139
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0135
6147 Solute carrier family 22 member 3 SLC22A3 0.0133
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0121
6144 Solute carrier family 22 member 2 SLC22A2 0.0116
6145 Solute carrier family 22 member 1 SLC22A1 0.0113
4512 Cytochrome P450 3A4 CYP3A4 0.0112
492 Histamine H1 receptor HRH1 0.0091
696 Kappa-type opioid receptor OPRK1 0.0089
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0088
6013 Cytochrome P450 2E1 CYP2E1 0.0081
587 Serum albumin ALB 0.007
6016 Cytochrome P450 2C19 CYP2C19 0.006
4119 Cytochrome P450 2D6 CYP2D6 0.0057
922 Glutamate receptor 4 GRIA4 0.0032
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0032
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0032
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0032
4018 Glutamate receptor delta-2 subunit GRID2 0.0032
4027 Glutamate receptor delta-1 subunit GRID1 0.0032
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0032
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0032
1912 Excitatory amino acid transporter 1 SLC1A3 0.0032
4019 Excitatory amino acid transporter 4 SLC1A6 0.0032
4026 Aspartyl aminopeptidase DNPEP 0.0032
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0032
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0032
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0032
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0032
4016 Excitatory amino acid transporter 5 SLC1A7 0.0032
4017 5-oxoprolinase OPLAH 0.0032
1047 Excitatory amino acid transporter 2 SLC1A2 0.0032
927 Metabotropic glutamate receptor 8 GRM8 0.0032
925 Metabotropic glutamate receptor 4 GRM4 0.0032
664 Glutamate decarboxylase 2 GAD2 0.0032
3890 Glutamate decarboxylase 2 GAD2 0.0032
926 Metabotropic glutamate receptor 7 GRM7 0.0032
4020 Glutamyl aminopeptidase ENPEP 0.0032
625 Glutamate carboxypeptidase 2 FOLH1 0.003
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0028
5 Glutaminase liver isoform, mitochondrial GLS2 0.0027
917 Glutaminase kidney isoform, mitochondrial GLS 0.0027
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0027
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0027
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0027
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0027
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0027
5261 Phosphoribosylformylglycinamidine synthase purL 0.0027
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0027
916 Metabotropic glutamate receptor 1 GRM1 0.0027
923 Glutamate receptor 3 GRIA3 0.0026
665 Phosphoserine aminotransferase PSAT1 0.0026
4652 Phosphoserine aminotransferase serC 0.0026
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0026
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0026
420 Glutamate decarboxylase 1 GAD1 0.0026
3900 Glutamate decarboxylase 1 GAD1 0.0026
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0026
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0025
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0025
1671 Excitatory amino acid transporter 3 SLC1A1 0.0025
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0025
426 Aspartate aminotransferase, mitochondrial GOT2 0.0025
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0024
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0024
3877 Growth-inhibiting protein 18 GIG18 0.0024
763 Tyrosine aminotransferase TAT 0.0023
5493 Tyrosine aminotransferase Not Available 0.0023
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0023
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0023
735 Alanine aminotransferase 1 GPT 0.0023
3904 Alanine aminotransferase 2 GPT2 0.0023
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0022
33 Cystine/glutamate transporter SLC7A11 0.0022
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0021
3426 Glutamine synthetase glnA 0.0021
3987 Glutamine synthetase GLUL 0.0021
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0021
705 Glutamate receptor 1 GRIA1 0.0021
738 Monocarboxylate transporter 1 SLC16A1 0.0018
921 Glutamate receptor 2 GRIA2 0.0016
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0016
↑