DT-Web

DB01775 - Dihydroxyacetone


Identification
Name Dihydroxyacetone
Accession Number DB01775 (EXPT00122)
Type small molecule
Description A ketotriose compound. Its addition to blood preservation solutions results in better maintenance of 2,3-diphosphoglycerate levels during storage. It is readily phosphorylated to dihydroxyacetone phosphate by triokinase in erythrocytes. In combination with naphthoquinones it acts as a sunscreening agent. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 90.0779
Groups experimental
Monoisotopic Weight 90.031694058
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Dihydroxyacetone kinase
Name Dihydroxyacetone kinase
Gene Name dhaK
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0217

Predictions


Id Partner name Gene Name Score
5641 Rod shape-determining protein MreB TM_0588 0.0213
3794 Osmolarity sensor protein envZ envZ 0.0213
4178 DNA repair protein RAD51 homolog 1 RAD51 0.0213
5645 DNA topoisomerase 4 subunit B parE 0.0213
6227 DNA topoisomerase 4 subunit B parE 0.0213
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0213
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0213
5644 Sensor protein phoQ phoQ 0.0213
5643 General secretion pathway protein E epsE 0.0213
5642 Chaperone clpB clpB 0.0213
5649 Potassium-transporting ATPase B chain kdpB 0.0213
2867 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ispE 0.0185
2282 Protein recA recA 0.0185
2315 Protein recA recA 0.0185
2332 Protein recA recA 0.0185
5263 Protein recA recA 0.0185
4751 Mitogen-activated protein kinase 12 MAPK12 0.0185
5646 Galactokinase GALK1 0.0185
740 Argininosuccinate synthase ASS1 0.0185
865 Argininosuccinate synthase ASS1 0.0185
2680 Argininosuccinate synthase argG 0.0185
3194 Argininosuccinate synthase argG 0.0185
6433 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 PFKFB4 0.0185
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0185
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0185
5302 TrwB trwB 0.0185
2852 DNA mismatch repair protein mutL mutL 0.0185
5265 FtsH ftsH 0.0185
2299 UDP-N-acetylmuramate--L-alanine ligase murC 0.0171
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0171
5312 Kinesin-like protein KIF1A KIF1A 0.0171
3231 Death-associated protein kinase 1 DAPK1 0.0171
2892 Acetylglutamate kinase argB 0.0161
3550 Acetylglutamate kinase argB 0.0161
2371 Pantothenate kinase coaA 0.0161
2615 Chemotaxis protein cheA cheA 0.0161
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0161
825 Arsenical pump-driving ATPase ASNA1 0.0161
3435 Arsenical pump-driving ATPase arsA 0.0161
1881 Hexokinase-1 HK1 0.0161
2727 S-adenosylmethionine synthetase metK 0.0154
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0149
887 DNA gyrase subunit B gyrB 0.0149
4150 DNA gyrase subunit B gyrB 0.0149
6225 DNA gyrase subunit B gyrB 0.0149
936 Ephrin type-A receptor 2 EPHA2 0.0148
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0147
958 Insulin-like growth factor 1 receptor IGF1R 0.0137
2251 Thymidylate kinase tmk 0.0132
2254 Thymidylate kinase DTYMK 0.0132
3522 Thymidylate kinase tmk 0.0132
3822 Actin, alpha skeletal muscle ACTA1 0.0125
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0123
1836 Mitogen-activated protein kinase 10 MAPK10 0.0121
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0119
207 Glutathione synthetase GSS 0.0118
5269 Glutathione synthetase gshB 0.0118
4192 DNA topoisomerase 2-beta TOP2B 0.0118
1721 Glycogen synthase kinase-3 beta GSK3B 0.0114
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0114
2236 Casein kinase II subunit alpha CSNK2A1 0.0113
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