DT-Web

DB01763 - Tatp


Identification
Name Tatp
Accession Number DB01763 (EXPT03005)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 759.471
Groups experimental
Monoisotopic Weight 759.052608109
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


NAD(P) transhydrogenase, mitochondrial
Name NAD(P) transhydrogenase, mitochondrial
Gene Name NNT
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.6402

Predictions


Id Partner name Gene Name Score
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0136
666 NADP-dependent malic enzyme ME1 0.0136
646 Malate dehydrogenase, cytoplasmic MDH1 0.0129
3778 NAD(P) transhydrogenase subunit beta pntB 0.0116
5332 MtdA bifunctional protein mtdA 0.0115
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0115
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0115
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0115
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0115
5322 Oxidoreductase ydhF ydhF 0.0115
4403 Protein iolS iolS 0.0115
5330 General stress protein 69 yhdN 0.0115
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0115
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0115
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0115
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0107
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0106
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0103
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0103
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.0101
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.01
5073 Ferredoxin--NADP reductase petH 0.01
5076 Ferredoxin--NADP reductase fpr 0.01
5119 Ferredoxin--NADP reductase petH 0.01
5121 Ferredoxin--NADP reductase fpr 0.01
654 Flavin reductase BLVRB 0.01
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0097
4582 Putative pteridine reductase 2 ptr2 0.0097
989 L-xylulose reductase DCXR 0.0096
5328 Prostaglandin F synthase Tb11.02.2310 0.0096
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0096
2636 Shikimate dehydrogenase aroE 0.0096
3515 Shikimate dehydrogenase aroE 0.0096
3446 NADP-dependent alcohol dehydrogenase adh 0.0096
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0096
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0096
2286 Isocitrate dehydrogenase [NADP] icd 0.0096
2302 Isocitrate dehydrogenase [NADP] icd 0.0096
2771 Isocitrate dehydrogenase [NADP] icd 0.0096
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0093
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0092
444 Alcohol dehydrogenase 1B ADH1B 0.009
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.0087
6297 Prostaglandin reductase 1 PTGR1 0.0087
3062 Aspartate-semialdehyde dehydrogenase asd 0.0087
4531 Putative ketoacyl reductase actIII 0.0087
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0087
2675 Pteridine reductase 1 PTR1 0.0085
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0085
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0085
2159 Quinone oxidoreductase CRYZ 0.0082
1124 Sepiapterin reductase SPR 0.0082
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0082
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0076
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0076
822 Aldose reductase AKR1B1 0.0075
365 Dihydrofolate reductase DHFR 0.0072
2381 Dihydrofolate reductase DFR1 0.0072
2833 Dihydrofolate reductase Not Available 0.0072
2931 Dihydrofolate reductase folA 0.0072
3544 Dihydrofolate reductase folA 0.0072
3682 Dihydrofolate reductase folA 0.0072
6642 Dihydrofolate reductase folA 0.0072
6756 Dihydrofolate reductase dfrA 0.0072
76 Nitric-oxide synthase, brain NOS1 0.0055
4120 NADPH--cytochrome P450 reductase POR 0.0053
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0043
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0043
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0043
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0043
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0043
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0043
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0043
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0043
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0043
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0043
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0043
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0043
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0043
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0043
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0043
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0043
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0043
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0043
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0043
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0043
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0043
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0043
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0043
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0043
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0043
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0043
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0043
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0043
3726 D-3-phosphoglycerate dehydrogenase serA 0.0043
4291 D-3-phosphoglycerate dehydrogenase serA 0.0043
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0043
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0043
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0043
644 Heme oxygenase 2 HMOX2 0.0043
4982 Heme oxygenase 2 pbsA2 0.0043
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0043
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0043
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0043
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0043
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0043
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0043
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0043
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0043
729 GDP-L-fucose synthetase TSTA3 0.0043
3463 GDP-L-fucose synthetase fcl 0.0043
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0043
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0043
107 C-4 methylsterol oxidase SC4MOL 0.0043
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0043
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0043
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0043
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0043
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0043
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0043
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0043
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0043
167 L-lactate dehydrogenase C chain LDHC 0.0043
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0043
206 3-keto-steroid reductase HSD17B7 0.0043
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0043
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0043
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0043
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0043
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0043
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0043
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0043
643 Peroxisomal bifunctional enzyme EHHADH 0.0043
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0043
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0043
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0043
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0043
34 7-dehydrocholesterol reductase DHCR7 0.0043
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0043
711 UDP-glucose 6-dehydrogenase UGDH 0.0043
3672 UDP-glucose 6-dehydrogenase hasB 0.0043
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0043
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0043
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0043
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0042
816 Biliverdin reductase A BLVRA 0.0039
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0039
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0039
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0039
857 Malate dehydrogenase, mitochondrial MDH2 0.0036
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0036
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0036
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0036
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0036
328 Sorbitol dehydrogenase SORD 0.0035
597 Dihydropteridine reductase QDPR 0.0035
396 Alcohol dehydrogenase 4 ADH4 0.0035
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0035
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0035
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0034
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0034
6026 Alcohol dehydrogenase 6 ADH6 0.0033
77 L-lactate dehydrogenase B chain LDHB 0.0033
12 Alcohol dehydrogenase class 3 ADH5 0.0033
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0032
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0032
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0032
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0032
473 L-lactate dehydrogenase A chain LDHA 0.0032
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0032
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0032
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0031
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0031
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0031
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0031
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0031
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0031
627 11-cis retinol dehydrogenase RDH5 0.0031
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0031
626 Cysteine dioxygenase type 1 CDO1 0.0031
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0031
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0031
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0031
13 Aminomethyltransferase, mitochondrial AMT 0.0031
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.003
166 NAD-dependent malic enzyme, mitochondrial ME2 0.003
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0028
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0028
569 Retinal dehydrogenase 2 ALDH1A2 0.0028
611 Retinal dehydrogenase 1 ALDH1A1 0.0027
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0027
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0027
251 Alcohol dehydrogenase 1A ADH1A 0.0027
810 Heme oxygenase 1 HMOX1 0.0026
3391 Heme oxygenase 1 pbsA1 0.0026
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0026
279 Tyrosinase TYR 0.0025
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0024
714 Glutathione reductase, mitochondrial GSR 0.0024
380 Cytochrome P450 17A1 CYP17A1 0.0023
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0023
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0022
517 Alcohol dehydrogenase 1C ADH1C 0.0022
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0021
468 Cytochrome P450 4A11 CYP4A11 0.0019
6020 Aldehyde oxidase AOX1 0.0019
3947 Xanthine dehydrogenase/oxidase XDH 0.0018
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