DT-Web

DB01433 - Methadyl Acetate


Identification
Name Methadyl Acetate
Accession Number DB01433
Type small molecule
Description A narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 353.4977
Groups illicit
Monoisotopic Weight 353.235479241
Pharmacology
Indication Used mainly in the treatment of narcotic dependence.
Mechanism of action Methadyl Acetate is primarily a mu-type opioid receptor agonist. It functions similarily to methadone.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Mu-type opioid receptor
Name Mu-type opioid receptor
Gene Name OPRM1
Pharmacological action yes
Actions agonist
References
  • Mancino MJ, McGaugh J, Feldman Z, Poling J, Oliveto A: Effect of PTSD diagnosis and contingency management procedures on cocaine use in dually cocaine- and opioid-dependent individuals maintained on LAAM: a retrospective analysis. Am J Addict. 2010 Mar;19(2):169-77. - Pubmed
  • Walczak SA, Makman MH, Gardner EL: Acetylmethadol metabolites influence opiate receptors and adenylate cyclase in amygdala. Eur J Pharmacol. 1981 Jul 10;72(4):343-9. - Pubmed
  • Wolstein J, Gastpar M, Finkbeiner T, Heinrich C, Heitkamp R, Poehlke T, Scherbaum N: A randomized, open-label trial comparing methadone and Levo-Alpha-Acetylmethadol (LAAM) in maintenance treatment of opioid addiction. Pharmacopsychiatry. 2009 Jan;42(1):1-8. Epub 2009 Jan 19. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.44

Predictions


Id Partner name Gene Name Score
467 Delta-type opioid receptor OPRD1 0.2329
696 Kappa-type opioid receptor OPRK1 0.2156
4512 Cytochrome P450 3A4 CYP3A4 0.0398
4119 Cytochrome P450 2D6 CYP2D6 0.0383
1716 Tripartite motif-containing protein 13 TRIM13 0.0335
6107 Cytochrome P450 3A7 CYP3A7 0.0261
1262 Corticotropin-lipotropin POMC 0.0243
4118 Cytochrome P450 3A5 CYP3A5 0.0184
1588 Multidrug resistance protein 1 ABCB1 0.0157
174 Sigma 1-type opioid receptor SIGMAR1 0.0153
4137 Nociceptin receptor OPRL1 0.0113
4924 Cytochrome P450 2C8 CYP2C8 0.0106
4757 Cytochrome P450 2C9 CYP2C9 0.0104
319 Opioid receptor, sigma 1 OPRS1 0.01
6030 Cytochrome P450 2B6 CYP2B6 0.009
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0085
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0084
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0081
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0072
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0065
4120 NADPH--cytochrome P450 reductase POR 0.006
3811 Cytochrome P450 19A1 CYP19A1 0.0058
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0058
341 5-hydroxytryptamine 3 receptor HTR3A 0.0057
587 Serum albumin ALB 0.0051
824 Sodium-dependent serotonin transporter SLC6A4 0.0049
1291 cAMP response element-binding protein CREB1 0.0049
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0048
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0048
4210 Toll-like receptor 4 TLR4 0.0044
6016 Cytochrome P450 2C19 CYP2C19 0.0043
4200 Cytochrome P450 1A2 CYP1A2 0.0041
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.004
1181 Alpha-1-acid glycoprotein 1 ORM1 0.004
6106 Cytochrome P450 2C18 CYP2C18 0.0038
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0037
94 5-hydroxytryptamine 4 receptor HTR4 0.0035
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0035
20 Prostaglandin G/H synthase 1 PTGS1 0.0029
465 Calmodulin CALM1 0.0028
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0026
885 5-hydroxytryptamine 1B receptor HTR1B 0.0025
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0025
6145 Solute carrier family 22 member 1 SLC22A1 0.0025
590 5-hydroxytryptamine 2C receptor HTR2C 0.0024
136 Estrogen receptor ESR1 0.0024
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0023
320 5-hydroxytryptamine 1A receptor HTR1A 0.0023
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0022
6013 Cytochrome P450 2E1 CYP2E1 0.0018
5718 Cytochrome P450 2A6 CYP2A6 0.0015
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0015
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