Identification | |
---|---|
Name | Nitroxoline |
Accession Number | DB01422 |
Type | small molecule |
Description | Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. It is a fluorquinolone that is active against bacterial gyrases. |
Structure |
|
Categories (*) | |
Molecular Weight | 190.1555 |
Groups | approved |
Monoisotopic Weight | 190.037842068 |
Pharmacology | |
Indication | Nitroxoline is an antibiotic agent. |
Mechanism of action | This drug may also have antitumor activity by inhibition of ype 2 methionine aminopeptidase (MetAP2) protein which is involved in angiogenesis. Its antibacterial activity may stem from the metal ion complexation vital for bacterial growth. |
Absorption | Not Available |
Protein binding | Not Available |
Biotransformation | Not Available |
Route of elimination | Not Available |
Toxicity | Not Available |
Affected organisms | Not Available |
Interactions | |
Drug Interactions | Not Available |
Food Interactions | Not Available |
Methionine aminopeptidase 1 | |
---|---|
Name | Methionine aminopeptidase 1 |
Gene Name | METAP1 |
Pharmacological action | yes |
Actions | inhibitor |
References |
|
DTHybrid score | 1.6248 |
Magnesium | |
Name | Magnesium |
Gene Name | Not Available |
Pharmacological action | unknown |
Actions | chelator |
References |
|
DTHybrid score | Not Available |
manganese | |
Name | manganese |
Gene Name | Not Available |
Pharmacological action | unknown |
Actions | chelator |
References |
|
DTHybrid score | Not Available |
Id | Partner name | Gene Name | Score |
---|---|---|---|
2795 | Methionine aminopeptidase 2 | METAP2 | 0.1224 |