DT-Web

DB01344 - Polystyrene sulfonate


Identification
Name Polystyrene sulfonate
Accession Number DB01344
Type small molecule
Description Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among others, HIV. [Wikipedia]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight Not Available
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication Used to treat abnormally high potassium levels.
Mechanism of action Polystyrene sulfonate, which is not absorbed, binds excess potassium, carrying it out of the body. The indigestible potassium polystryene sulfonate complex is excreted with the faeces, preventing the absorption of potassium into the blood stream. Hence, the serum potassium level decreases.
Absorption Not absorbed following oral administration.
Protein binding Not Available
Biotransformation none
Route of elimination Feces.
Toxicity Overdose symptoms may include confusion, irritability, trouble thinking or concentrating, muscle weakness, or trouble breathing.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Aluminium Risk of alkalosis in renal impairment
Amiloride Risk of alkalosis in renal impairment
Calcium Formation of non-absorbable complexes
Eplerenone Risk of alkalosis in renal impairment
Magnesium Risk of alkalosis in renal impairment
Potassium Risk of alkalosis in renal impairment
Spironolactone Risk of alkalosis in renal impairment
Triamterene Antagonism of action
Food Interactions
  • Avoid calcium, magnesium and potassium.
  • Take on an empty stomach.

Targets


Potassium
Name Potassium
Gene Name Not Available
Pharmacological action yes
Actions binder
References
  • Watson M, Abbott KC, Yuan CM: Damned if you do, damned if you don't: potassium binding resins in hyperkalemia. Clin J Am Soc Nephrol. 2010 Oct;5(10):1723-6. Epub 2010 Aug 26. - Pubmed
  • Sterns RH, Rojas M, Bernstein P, Chennupati S: Ion-exchange resins for the treatment of hyperkalemia: are they safe and effective? J Am Soc Nephrol. 2010 May;21(5):733-5. Epub 2010 Feb 18. - Pubmed
  • Hoffman RS, Stringer JA, Feinberg RS, Goldfrank LR: Comparative efficacy of thallium adsorption by activated charcoal, prussian blue, and sodium polystyrene sulfonate. J Toxicol Clin Toxicol. 1999;37(7):833-7. - Pubmed
DTHybrid score Not Available

Predictions


Id Partner name Gene Name Score
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