Identification | |
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Name | Rescinnamine |
Accession Number | DB01180 (APRD00112) |
Type | small molecule |
Description | Rescinnamine is an angiotensin-converting enzyme inhibitor used as an antihypertensive drug. It is an alkaloid obtained from Rauwolfia serpentina and other species of Rauwolfia. [Wikipedia] |
Structure |
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Categories (*) | |
Molecular Weight | 634.716 |
Groups | approved |
Monoisotopic Weight | 634.289030952 |
Pharmacology | |
Indication | For the treatment of hypertension. |
Mechanism of action | Rescinnamine Binds to and inhibits the angiotensin converting enzyme. Rescinnamine competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. Inhibition of ACE results in decreased plasma angiotensin II. As angiotensin II is a vasoconstrictor and a negative-feedback mediator for renin activity, lower concentrations result in a decrease in blood pressure and stimulation of baroreceptor reflex mechanisms, which leads to decreased vasopressor activity and to decreased aldosterone secretion. |
Absorption | Not Available |
Protein binding | Not Available |
Biotransformation | Not Available |
Route of elimination | Not Available |
Toxicity | Not Available |
Affected organisms |
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Interactions | |
Drug Interactions | Not Available |
Food Interactions | Not Available |
Angiotensin-converting enzyme | |
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Name | Angiotensin-converting enzyme |
Gene Name | ACE |
Pharmacological action | yes |
Actions | inhibitor |
References |
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DTHybrid score | 0.4741 |