DT-Web

DB01163 - Amdinocillin


Identification
Name Amdinocillin
Accession Number DB01163 (APRD00789)
Type small molecule
Description Amidinopenicillanic acid derivative with broad spectrum antibacterial action. It is poorly absorbed if given orally and is used in urinary infections and typhus. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 325.426
Groups approved
Monoisotopic Weight 325.146012307
Pharmacology
Indication Used in the treatment of urinary tract infections caused by some strains of E. coli and klebsiella and enterobacter species. Used mainly against Gram negative organisms.
Mechanism of action Amdinocillin is a stong and specific antagonist of Penicillin Binding Protein-2 (PBP 2). It is active against gram negative bacteria, preventing cell wall synthesis by inhibiting the activity of PBP2. PBP2 is a peptidoglycan elongation initiating enzyme. Peptidoglycan is a polymer of sugars and amino acids that is the main component of bacterial cell walls.
Absorption Poorly absorbed if given orally.
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Gram-negative Bacteria
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Penicillin-binding protein 2a
Name Penicillin-binding protein 2a
Gene Name pbp2a
Pharmacological action yes
Actions inhibitor
References
  • Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. - Pubmed
DTHybrid score Not Available
Penicillin-binding protein 2
Name Penicillin-binding protein 2
Gene Name mrdA
Pharmacological action yes
Actions inhibitor
References
  • Neu HC: Penicillin-binding proteins and role of amdinocillin in causing bacterial cell death. Am J Med. 1983 Aug 29;75(2A):9-20. - Pubmed
  • Licht J, Gally D, Henderson T, Young K, Cooper S: Effect of mecillinam on peptidoglycan synthesis during the division cycle of Salmonella typhimurium 2616. Res Microbiol. 1993 Jul-Aug;144(6):423-33. - Pubmed
DTHybrid score 0.008
Penicillin-binding protein 3
Name Penicillin-binding protein 3
Gene Name pbp3
Pharmacological action yes
Actions inhibitor
References
  • Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. - Pubmed
DTHybrid score 0.0287
Penicillin-binding protein 1A
Name Penicillin-binding protein 1A
Gene Name pbpA
Pharmacological action yes
Actions inhibitor
References
  • Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. - Pubmed
DTHybrid score 0.03
Penicillin-binding protein 2B
Name Penicillin-binding protein 2B
Gene Name penA
Pharmacological action yes
Actions inhibitor
References
  • Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. - Pubmed
DTHybrid score 0.7184
Penicillin-binding protein 1b
Name Penicillin-binding protein 1b
Gene Name pbp1b
Pharmacological action yes
Actions inhibitor
References
  • Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. - Pubmed
DTHybrid score 0.0305

Predictions


Id Partner name Gene Name Score
159 Penicillin-binding protein 2B penA 0.7184
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.2024
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.1927
1729 Solute carrier family 22 member 6 SLC22A6 0.1157
118 Organic cation/carnitine transporter 2 SLC22A5 0.1066
633 Penicillin-binding proteins 1A/1B pbpA 0.0999
6113 MecA PBP2' (penicillin binding protein 2') mecA 0.0796
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0747
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0747
6142 Solute carrier family 22 member 8 SLC22A8 0.0624
587 Serum albumin ALB 0.0425
4512 Cytochrome P450 3A4 CYP3A4 0.0409
1024 Solute carrier family 22 member 11 SLC22A11 0.0367
3195 Beta-lactamase Toho-1 bla 0.0357
332 Beta-lactamase blaZ 0.0334
2478 Beta-lactamase ampC 0.0334
2613 Beta-lactamase ampC 0.0334
2635 Beta-lactamase ampC 0.0334
2700 Beta-lactamase penP 0.0334
5445 Beta-lactamase blaB 0.0334
6019 Beta-lactamase SHV-7 0.0334
6701 Beta-lactamase cphA 0.0334
543 Penicillin-binding protein 1B mrcB 0.0305
6186 Penicillin-binding protein 1B ponB 0.0305
6822 Penicillin-binding protein 1b pbp1b 0.0305
1 Peptidoglycan synthetase ftsI ftsI 0.0304
4155 Peptidoglycan synthetase ftsI ftsI 0.0304
645 Penicillin-binding protein 1A mrcA 0.03
5805 Penicillin-binding protein 1A ponA 0.03
6185 Penicillin-binding protein 1A mrcA 0.03
3760 Penicillin-binding protein 5 precursor dacA 0.0291
867 Penicillin-binding protein 3 pbpC 0.0287
6119 Penicillin-binding protein 3 pbp3 0.0287
7157 Penicillin-binding protein 3 LMHCC_2184 0.0287
7162 Penicillin-binding protein 3 pbpB 0.0287
7172 Penicillin-binding protein 3 pbp3 0.0287
6143 Solute carrier family 22 member 7 SLC22A7 0.0285
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0275
819 Penicillin-binding protein 4 dacB 0.0258
738 Monocarboxylate transporter 1 SLC16A1 0.0238
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0198
4200 Cytochrome P450 1A2 CYP1A2 0.0193
6067 Penicillin binding protein 2a mecA 0.0162
3426 Glutamine synthetase glnA 0.0097
3987 Glutamine synthetase GLUL 0.0097
4119 Cytochrome P450 2D6 CYP2D6 0.0091
115 Penicillin-binding protein 2 mrdA 0.008
6069 Penicillin-binding protein 2 mrdA 0.008
6118 Penicillin-binding protein 2 penA 0.008
6187 Penicillin-binding protein 2 pbpA 0.008
6686 Penicillin-binding protein 2 pbp2 0.008
7163 Penicillin-binding protein 2 pbpA 0.008
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