DT-Web

DB01145 - Sulfoxone


Identification
Name Sulfoxone
Accession Number DB01145 (APRD00704)
Type small molecule
Description Sulfoxone is a water-soluble sulfone used as an antileprosy drug. It has been used with limited success in the treatment of dermatitis herpetiformis.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 404.482
Groups approved
Monoisotopic Weight 404.017048324
Pharmacology
Indication For the treatment of leprosy and dermatitis herpetiformis
Mechanism of action Sulfoxone is a competitive inhibitor of bacterial enzyme dihydropteroate synthetase. The normal substrate for the enzyme, para-aminobenzoic acid (PABA) cannot bind as usual. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Absorption Rapidly absorbed.
Protein binding 69%
Biotransformation Hepatic.
Route of elimination Not Available
Toxicity Oral, rat LD50: 7000 mg/kg
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Dihydropteroate synthetase
Name Dihydropteroate synthetase
Gene Name Not Available
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Katz SI: - Sulfoxone (Diasone) sodium for dermatitis herpetiformis
  • Takahashi T: [Mutations of drug target molecules in Pneumocystis jirovecii isolates and future investigations] Nippon Ishinkin Gakkai Zasshi. 2009;50(2):67-73. - Pubmed
DTHybrid score 1.0586

Predictions


Id Partner name Gene Name Score
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.1176
3811 Cytochrome P450 19A1 CYP19A1 0.064
4757 Cytochrome P450 2C9 CYP2C9 0.0616
6013 Cytochrome P450 2E1 CYP2E1 0.0205
4924 Cytochrome P450 2C8 CYP2C8 0.019
4512 Cytochrome P450 3A4 CYP3A4 0.0153
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