DB01130 - Prednicarbate
| Identification | |
|---|---|
| Name | Prednicarbate |
| Accession Number | DB01130 (APRD01197) |
| Type | small molecule |
| Description | Prednicarbate is a relatively new topical corticosteroid drug. It is similar in potency to hydrocortisone. It is used in the treatment of inflammatory skin diseases, such as atopic dermatitis. It has a favorable benefit-risk ratio, with an inflammatory action similar to that of a medium potency corticosteroid, but with a low potential to cause skin atrophy. The anti-inflammation action of corticosteroids is associated with the inhibition of the interleukin 1-alpha cytokine within keratinocytes. IL-1a is also found in fibroblasts, where it is responsible for proliferation, collagenase induction and IL-6 synthesis, which are related to skin thickness. |
| Structure |
|
| Categories (*) | |
| Molecular Weight | 488.5699 |
| Groups | approved |
| Monoisotopic Weight | 488.241018128 |
| Pharmacology | |
| Indication | For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. |
| Mechanism of action | In common with other topical corticosteroids, prednicarbate has anti-inflammatory, antipruritic, and vasoconstrictive properties. In general, the mechanism of the anti-inflammatory activity of topical steroids is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. |
| Absorption | Absorbed systemically across the stratum corneum. |
| Protein binding | Not Available |
| Biotransformation | Primarily in skin |
| Route of elimination | Not Available |
| Toxicity | Not Available |
| Affected organisms |
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| Interactions | |
| Drug Interactions | Not Available |
| Food Interactions | Not Available |
Targets
| Glucocorticoid receptor | |
|---|---|
| Name | Glucocorticoid receptor |
| Gene Name | NR3C1 |
| Pharmacological action | yes |
| Actions | agonist |
| References |
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| DTHybrid score | 0.778 |