DT-Web

DB01038 - Carphenazine


Identification
Name Carphenazine
Accession Number DB01038 (APRD00848)
Type small molecule
Description Carphenazine is an antipsychotic drug, used in hospitalized patients in the management of chronic schizophrenic psychoses.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 411.56
Groups approved
Monoisotopic Weight 411.198047877
Pharmacology
Indication Used in the treatment of acute or chronic schizophrenic reactions in hospitalized patients.
Mechanism of action A yellow, powdered, phenothiazine antipsychotic agent used in the treatment of acute or chronic schizophrenia. The term "phenothiazines" is used to describe the largest of the five main classes of neuroleptic antipsychotic drugs. These drugs have antipsychotic and, often, antiemetic properties, although they may also cause severe side effects such as akathisia, tardive dyskinesia and extrapyramidal symptoms. Carphenazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


D(2) dopamine receptor
Name D(2) dopamine receptor
Gene Name DRD2
Pharmacological action yes
Actions antagonist
References
  • Vinar O, Formankova M, Taussigova D, Ruzicka S: Carphenazine in the treatment of schizophrenic psychoses. Controlled clinical trial. Act Nerv Super (Praha). 1967 Nov;9(4):353-5. - Pubmed
  • Bora G: Comparison of dosage ranges of carphenazine and trifluoperazine in elderly chronic schizophrenics. Dis Nerv Syst. 1968 Oct;29(10):695-7. - Pubmed
  • Platz AR, Klett CJ, Caffey EM Jr: Selective drug action related to chronic schizophrenic subtype. (A comparative study of carphenazine, chlorpromazine, and trifluoperazine). Dis Nerv Syst. 1967 Sep;28(9):601-5. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.379
D(1A) dopamine receptor
Name D(1A) dopamine receptor
Gene Name DRD1
Pharmacological action yes
Actions antagonist
References
  • Vinar O, Formankova M, Taussigova D, Ruzicka S: Carphenazine in the treatment of schizophrenic psychoses. Controlled clinical trial. Act Nerv Super (Praha). 1967 Nov;9(4):353-5. - Pubmed
  • Bora G: Comparison of dosage ranges of carphenazine and trifluoperazine in elderly chronic schizophrenics. Dis Nerv Syst. 1968 Oct;29(10):695-7. - Pubmed
  • Platz AR, Klett CJ, Caffey EM Jr: Selective drug action related to chronic schizophrenic subtype. (A comparative study of carphenazine, chlorpromazine, and trifluoperazine). Dis Nerv Syst. 1967 Sep;28(9):601-5. - Pubmed
DTHybrid score 0.3374
D(1B) dopamine receptor
Name D(1B) dopamine receptor
Gene Name DRD5
Pharmacological action yes
Actions antagonist
References
  • Vinar O, Formankova M, Taussigova D, Ruzicka S: Carphenazine in the treatment of schizophrenic psychoses. Controlled clinical trial. Act Nerv Super (Praha). 1967 Nov;9(4):353-5. - Pubmed
  • Bora G: Comparison of dosage ranges of carphenazine and trifluoperazine in elderly chronic schizophrenics. Dis Nerv Syst. 1968 Oct;29(10):695-7. - Pubmed
  • Platz AR, Klett CJ, Caffey EM Jr: Selective drug action related to chronic schizophrenic subtype. (A comparative study of carphenazine, chlorpromazine, and trifluoperazine). Dis Nerv Syst. 1967 Sep;28(9):601-5. - Pubmed
DTHybrid score 0.1966

Predictions


Id Partner name Gene Name Score
502 5-hydroxytryptamine 2A receptor HTR2A 0.171
432 D(4) dopamine receptor DRD4 0.1284
638 D(3) dopamine receptor DRD3 0.127
318 Alpha-2A adrenergic receptor ADRA2A 0.1136
4119 Cytochrome P450 2D6 CYP2D6 0.1035
320 5-hydroxytryptamine 1A receptor HTR1A 0.1029
629 Alpha-2B adrenergic receptor ADRA2B 0.1013
556 Alpha-1A adrenergic receptor ADRA1A 0.0977
590 5-hydroxytryptamine 2C receptor HTR2C 0.0958
378 Alpha-2C adrenergic receptor ADRA2C 0.0934
632 Alpha-1B adrenergic receptor ADRA1B 0.0699
725 5-hydroxytryptamine 1D receptor HTR1D 0.0685
4512 Cytochrome P450 3A4 CYP3A4 0.0662
436 5-hydroxytryptamine 2B receptor HTR2B 0.0661
885 5-hydroxytryptamine 1B receptor HTR1B 0.0637
4200 Cytochrome P450 1A2 CYP1A2 0.0596
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0498
716 5-hydroxytryptamine 7 receptor HTR7 0.0447
1588 Multidrug resistance protein 1 ABCB1 0.0392
492 Histamine H1 receptor HRH1 0.0389
6145 Solute carrier family 22 member 1 SLC22A1 0.0326
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0317
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0308
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0299
789 Alpha-1D adrenergic receptor ADRA1D 0.0292
1256 5-hydroxytryptamine 6 receptor HTR6 0.0272
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0266
6016 Cytochrome P450 2C19 CYP2C19 0.0239
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0236
587 Serum albumin ALB 0.0208
528 5-hydroxytryptamine 1E receptor HTR1E 0.02
4757 Cytochrome P450 2C9 CYP2C9 0.0198
4118 Cytochrome P450 3A5 CYP3A5 0.0189
6107 Cytochrome P450 3A7 CYP3A7 0.018
6013 Cytochrome P450 2E1 CYP2E1 0.0173
465 Calmodulin CALM1 0.0168
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0162
341 5-hydroxytryptamine 3 receptor HTR3A 0.0157
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0155
3941 Amine oxidase [flavin-containing] A MAOA 0.014
3923 Cholinesterase BCHE 0.0135
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0129
6144 Solute carrier family 22 member 2 SLC22A2 0.0121
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.012
824 Sodium-dependent serotonin transporter SLC6A4 0.0117
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0102
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0097
4924 Cytochrome P450 2C8 CYP2C8 0.0091
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0088
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0087
6151 Monocarboxylate transporter 10 SLC16A10 0.0086
6030 Cytochrome P450 2B6 CYP2B6 0.0081
713 Sodium-dependent dopamine transporter SLC6A3 0.0081
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.008
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0078
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0077
153 Dopamine beta-hydroxylase DBH 0.0077
3939 Amine oxidase [flavin-containing] B MAOB 0.0075
923 Glutamate receptor 3 GRIA3 0.0074
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0074
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0063
3810 Catechol O-methyltransferase COMT 0.0061
131 Synaptic vesicular amine transporter SLC18A2 0.006
193 Beta-1 adrenergic receptor ADRB1 0.006
3426 Glutamine synthetase glnA 0.0056
3987 Glutamine synthetase GLUL 0.0056
6147 Solute carrier family 22 member 3 SLC22A3 0.0053
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0053
174 Sigma 1-type opioid receptor SIGMAR1 0.0048
118 Organic cation/carnitine transporter 2 SLC22A5 0.0046
921 Glutamate receptor 2 GRIA2 0.0045
6106 Cytochrome P450 2C18 CYP2C18 0.0042
6024 Cytochrome P450 1A1 CYP1A1 0.0042
6859 Protein S100-A4 S100A4 0.0041
474 Acetylcholinesterase ACHE 0.0041
94 5-hydroxytryptamine 4 receptor HTR4 0.004
694 Matrix protein 2 M 0.0039
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0038
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0036
380 Cytochrome P450 17A1 CYP17A1 0.0035
427 Substance-P receptor TACR1 0.0034
124 Histamine H2 receptor HRH2 0.0032
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0031
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0029
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0027
776 Bile salt export pump ABCB11 0.0027
5718 Cytochrome P450 2A6 CYP2A6 0.002
3947 Xanthine dehydrogenase/oxidase XDH 0.002
164 Histamine H4 receptor HRH4 0.002
766 Beta-2 adrenergic receptor ADRB2 0.0018
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0018
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0018
20 Prostaglandin G/H synthase 1 PTGS1 0.0017
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0017
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0016
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0015
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0015
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0014
1898 Cytochrome P450 1B1 CYP1B1 0.0011
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