DB00587 - Cinalukast
| Identification | |
|---|---|
| Name | Cinalukast |
| Accession Number | DB00587 (APRD00637) |
| Type | small molecule |
| Description | Used in the treatment of asthma, cinalukast selectively antagonizes leukotriene D4 (LTD4) at the cysteinyl leukotriene receptor, CysLT1, in the human airway. Cinalukast inhibits the actions of LTD4 at the CysLT1 receptor, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus. |
| Structure |
|
| Categories (*) | |
| Molecular Weight | 412.545 |
| Groups | approved |
| Monoisotopic Weight | 412.182063462 |
| Pharmacology | |
| Indication | For Protection against second- phase inflamation in exercise-induced bronchoconstriction and Asthma. |
| Mechanism of action | Binds to the cysteinyl leukotriene receptor. The cysteinyl leukotrienes (LTC4, LTD4, LTE4) are products of arachidonic acid metabolism and are released from various cells, including mast cells and eosinophils. These eicosanoids bind to cysteinyl leukotriene receptors (CysLT) found in the human airway. Cysteinyl leukotrienes and leukotriene receptor occupation have been correlated with the pathophysiology of asthma, including airway edema, smooth muscle contraction, and altered cellular activity associated with the inflammatory process, which contribute to the signs and symptoms of asthma. |
| Absorption | Not Available |
| Protein binding | Not Available |
| Biotransformation | Not Available |
| Route of elimination | Not Available |
| Toxicity | Not Available |
| Affected organisms |
|
| Interactions | |
| Drug Interactions | Not Available |
| Food Interactions | Not Available |
Targets
| Cysteinyl leukotriene receptor 1 | |
|---|---|
| Name | Cysteinyl leukotriene receptor 1 |
| Gene Name | CYSLTR1 |
| Pharmacological action | yes |
| Actions | antagonist |
| References |
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| DTHybrid score | 0.4639 |