Identification | |
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Name | Sodium Tetradecyl Sulfate |
Accession Number | DB00464 (APRD00575) |
Type | small molecule |
Description | An anionic surface-active agent used for its wetting properties in industry and used in medicine as an irritant and sclerosing agent for hemorrhoids and varicose veins. |
Structure |
|
Categories (*) | |
Molecular Weight | 294.451 |
Groups | approved |
Monoisotopic Weight | 294.186480138 |
Pharmacology | |
Indication | For the treatment of small uncomplicated varicose veins of the lower extremities that show simple dilation with competent valves. |
Mechanism of action | Sodium tetradecyl sulfate is a potent toxin for endothelial cells in that brief exposure to even low concentrations are effective in stripping endothelium over a considerable distance and exposing highly thrombogenic endothelium in the process. Diluted sodium tetradecyl sulfate is also able to induce a hypercoagulable state, possibly by selective inhibition of protein C, and can also promote platelet aggregation. |
Absorption | Not Available |
Protein binding | Not Available |
Biotransformation | Not Available |
Route of elimination | Not Available |
Toxicity | LD50=1250 mg/kg (Orally in rat); LD50=3 ml/kg (Skin in rat) |
Affected organisms |
|
Interactions | |
Drug Interactions | Not Available |
Food Interactions | Not Available |
Vitamin K-dependent protein C | |
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Name | Vitamin K-dependent protein C |
Gene Name | PROC |
Pharmacological action | yes |
Actions | inhibitor |
References |
|
DTHybrid score | 0.6694 |
Vitamin K-dependent protein S | |
Name | Vitamin K-dependent protein S |
Gene Name | PROS1 |
Pharmacological action | yes |
Actions | inhibitor |
References |
|
DTHybrid score | 0.6733 |