DT-Web

DB00391 - Sulpiride


Identification
Name Sulpiride
Accession Number DB00391 (APRD00032)
Type small molecule
Description A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed)
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 341.426
Groups approved
Monoisotopic Weight 341.140926929
Pharmacology
Indication Sulpiride is indicated for the treatment of schizophrenia.
Mechanism of action In contrast to most other neuroleptics which block both dopamine D1 and D2 receptors, Sulpiride is more selective and acts primarily as a dopamine D2 antagonist. Sulpiride appears to lack effects on norepinephrine, acetylcholine, serotonin, histamine, or gamma-aminobutyric acid (GABA) receptors.
Absorption Sulpiride is absorbed slowly from the gastrointestinal tract. Its oral bioavailability is only 25 to 35% with marked interindividual differences.
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Sulpiride has a relatively low order of acute toxicity. Substantial amounts may cause severe but reversible dystonic crises with torticollis, protrusion of the tongue, and/or trism. In some cases all the classical symptoms typical of severe Parkinson's Disease may be noted; in others, over-sedation/coma may occur.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


D(2) dopamine receptor
Name D(2) dopamine receptor
Gene Name DRD2
Pharmacological action yes
Actions antagonist
References
  • Cavallotti C, Nuti F, Bruzzone P, Mancone M: Age-related changes in dopamine D2 receptors in rat heart and coronary vessels. Clin Exp Pharmacol Physiol. 2002 May-Jun;29(5-6):412-8. - Pubmed
  • Jaber M, Tison F, Fournier MC, Bloch B: Differential influence of haloperidol and sulpiride on dopamine receptors and peptide mRNA levels in the rat striatum and pituitary. Brain Res Mol Brain Res. 1994 Apr;23(1-2):14-20. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.3047
D(3) dopamine receptor
Name D(3) dopamine receptor
Gene Name DRD3
Pharmacological action unknown
Actions antagonist
References
  • Lipina TV, Vishnivetskaia GB: [Effect of sulpiride on immobility reflex and pinch-induced catalepsy in CBA/Lac male mice with various social status] Zh Vyssh Nerv Deiat Im I P Pavlova. 2009 Jul-Aug;59(4):482-7. - Pubmed
  • Collo G, Zanetti S, Missale C, Spano P: Dopamine D3 receptor-preferring agonists increase dendrite arborization of mesencephalic dopaminergic neurons via extracellular signal-regulated kinase phosphorylation. Eur J Neurosci. 2008 Oct;28(7):1231-40. - Pubmed
DTHybrid score 0.1679

Enzymes


Cholinesterase
Name Cholinesterase
Gene Name BCHE
Actions inhibitor
References
  • Vacca C, Maione S, Tozzi A, Marmo E: Benzamides and cholinesterases. Res Commun Chem Pathol Pharmacol. 1987 Feb;55(2):193-201. - Pubmed
  • Dross K: [The relevance of anticholinesterase properties to toxicity and neuromuscular effects of sulpiride (author's transl)]. Arzneimittelforschung. 1977 Feb;27(2):404-6. - Pubmed
DTHybrid score 0.5791

Predictions


Id Partner name Gene Name Score
502 5-hydroxytryptamine 2A receptor HTR2A 0.1277
23 D(1A) dopamine receptor DRD1 0.1272
474 Acetylcholinesterase ACHE 0.0955
4119 Cytochrome P450 2D6 CYP2D6 0.0897
432 D(4) dopamine receptor DRD4 0.0881
320 5-hydroxytryptamine 1A receptor HTR1A 0.0731
4512 Cytochrome P450 3A4 CYP3A4 0.0676
163 D(1B) dopamine receptor DRD5 0.0656
590 5-hydroxytryptamine 2C receptor HTR2C 0.0653
556 Alpha-1A adrenergic receptor ADRA1A 0.0638
629 Alpha-2B adrenergic receptor ADRA2B 0.0595
378 Alpha-2C adrenergic receptor ADRA2C 0.0581
318 Alpha-2A adrenergic receptor ADRA2A 0.0577
1588 Multidrug resistance protein 1 ABCB1 0.0549
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0518
4200 Cytochrome P450 1A2 CYP1A2 0.0508
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0501
725 5-hydroxytryptamine 1D receptor HTR1D 0.0491
716 5-hydroxytryptamine 7 receptor HTR7 0.0466
436 5-hydroxytryptamine 2B receptor HTR2B 0.0439
885 5-hydroxytryptamine 1B receptor HTR1B 0.0439
632 Alpha-1B adrenergic receptor ADRA1B 0.0388
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0359
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0328
492 Histamine H1 receptor HRH1 0.0319
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0282
766 Beta-2 adrenergic receptor ADRB2 0.0255
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0246
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0245
4118 Cytochrome P450 3A5 CYP3A5 0.024
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0238
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0236
6145 Solute carrier family 22 member 1 SLC22A1 0.023
6107 Cytochrome P450 3A7 CYP3A7 0.0228
1256 5-hydroxytryptamine 6 receptor HTR6 0.0224
2433 Capsid protein P40 UL80 0.0213
3569 Capsid protein P40 BVRF2 0.0213
6016 Cytochrome P450 2C19 CYP2C19 0.0197
465 Calmodulin CALM1 0.0192
2049 Gastrin/cholecystokinin type B receptor CCKBR 0.0191
3076 Antigen 85-C fbpC 0.0187
789 Alpha-1D adrenergic receptor ADRA1D 0.0178
341 5-hydroxytryptamine 3 receptor HTR3A 0.0173
6030 Cytochrome P450 2B6 CYP2B6 0.0159
6013 Cytochrome P450 2E1 CYP2E1 0.0158
4757 Cytochrome P450 2C9 CYP2C9 0.0152
2796 Parathion hydrolase opd 0.0147
6539 Parathion hydrolase opd 0.0147
174 Sigma 1-type opioid receptor SIGMAR1 0.0146
6144 Solute carrier family 22 member 2 SLC22A2 0.0142
3454 Esterase estA 0.0141
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0137
587 Serum albumin ALB 0.013
528 5-hydroxytryptamine 1E receptor HTR1E 0.0126
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0126
2929 (S)-2-haloacid dehalogenase dhlB 0.0124
2995 (S)-2-haloacid dehalogenase Not Available 0.0124
734 D1 dopamine receptor-interacting protein calcyon CALY 0.012
124 Histamine H2 receptor HRH2 0.0119
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0114
131 Synaptic vesicular amine transporter SLC18A2 0.011
713 Sodium-dependent dopamine transporter SLC6A3 0.0108
290 Prostaglandin G/H synthase 2 PTGS2 0.0105
244 Angiotensin-converting enzyme ACE 0.0101
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0097
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.009
4924 Cytochrome P450 2C8 CYP2C8 0.0089
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0087
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0086
20 Prostaglandin G/H synthase 1 PTGS1 0.0085
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0082
275 Arachidonate 5-lipoxygenase ALOX5 0.0079
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0075
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0074
923 Glutamate receptor 3 GRIA3 0.0074
6147 Solute carrier family 22 member 3 SLC22A3 0.0073
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0071
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.007
85 Growth hormone receptor GHR 0.0065
3947 Xanthine dehydrogenase/oxidase XDH 0.0065
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0065
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0055
3811 Cytochrome P450 19A1 CYP19A1 0.0055
118 Organic cation/carnitine transporter 2 SLC22A5 0.0055
3939 Amine oxidase [flavin-containing] B MAOB 0.0054
824 Sodium-dependent serotonin transporter SLC6A4 0.0054
6024 Cytochrome P450 1A1 CYP1A1 0.0051
6151 Monocarboxylate transporter 10 SLC16A10 0.005
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.005
3941 Amine oxidase [flavin-containing] A MAOA 0.005
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0049
737 Mineralocorticoid receptor NR3C2 0.0048
1656 CYP2B protein CYP2B 0.0047
4784 Beta-mannosidase manB 0.0046
6695 Beta-mannosidase BT_0458 0.0046
921 Glutamate receptor 2 GRIA2 0.0045
153 Dopamine beta-hydroxylase DBH 0.0044
614 Progesterone receptor PGR 0.0043
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0043
6106 Cytochrome P450 2C18 CYP2C18 0.0043
232 Corticosteroid-binding globulin SERPINA6 0.0043
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0042
6859 Protein S100-A4 S100A4 0.0041
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0041
3480 Mannan endo-1,4-beta-mannosidase manA 0.0041
468 Cytochrome P450 4A11 CYP4A11 0.0041
94 5-hydroxytryptamine 4 receptor HTR4 0.004
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.004
146 Androgen receptor AR 0.0039
694 Matrix protein 2 M 0.0039
871 Glucocorticoid receptor NR3C1 0.0036
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0036
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0036
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0036
4787 Envelope glycoprotein gp160 env 0.0036
4820 Envelope glycoprotein gp160 env 0.0036
5727 Envelope glycoprotein gp160 env 0.0036
144 Hemoglobin subunit alpha HBA1 0.0036
3810 Catechol O-methyltransferase COMT 0.0035
380 Cytochrome P450 17A1 CYP17A1 0.0035
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0035
2297 Genome polyprotein Not Available 0.0034
2322 Genome polyprotein Not Available 0.0034
2694 Genome polyprotein Not Available 0.0034
2719 Genome polyprotein Not Available 0.0034
2860 Genome polyprotein Not Available 0.0034
2928 Genome polyprotein Not Available 0.0034
3160 Genome polyprotein Not Available 0.0034
3260 Genome polyprotein Not Available 0.0034
4783 Genome polyprotein Not Available 0.0034
5726 Genome polyprotein Not Available 0.0034
5779 Genome polyprotein Not Available 0.0034
5867 Genome polyprotein Not Available 0.0034
6253 Genome polyprotein Not Available 0.0034
6301 Genome polyprotein Not Available 0.0034
6380 Genome polyprotein Not Available 0.0034
6381 Genome polyprotein Not Available 0.0034
6437 Genome polyprotein Not Available 0.0034
6520 Genome polyprotein Not Available 0.0034
6521 Genome polyprotein Not Available 0.0034
6652 Genome polyprotein Not Available 0.0034
6734 Genome polyprotein Not Available 0.0034
6735 Genome polyprotein Not Available 0.0034
6736 Genome polyprotein Not Available 0.0034
6737 Genome polyprotein Not Available 0.0034
6738 Genome polyprotein Not Available 0.0034
6739 Genome polyprotein Not Available 0.0034
6744 Genome polyprotein Not Available 0.0034
6748 Genome polyprotein Not Available 0.0034
6894 Genome polyprotein Not Available 0.0034
6898 Genome polyprotein Not Available 0.0034
427 Substance-P receptor TACR1 0.0034
1517 Beta-3 adrenergic receptor ADRB3 0.0033
3426 Glutamine synthetase glnA 0.0033
3987 Glutamine synthetase GLUL 0.0033
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0032
833 Organic cation/carnitine transporter 1 SLC22A4 0.0032
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0031
1178 Adenosine A2a receptor ADORA2A 0.0031
3437 Eosinophil lysophospholipase CLC 0.003
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0027
6131 Carbonic anhydrase 14 CA14 0.0026
164 Histamine H4 receptor HRH4 0.0025
193 Beta-1 adrenergic receptor ADRB1 0.0024
2207 Rhodopsin RHO 0.0024
776 Bile salt export pump ABCB11 0.0023
5718 Cytochrome P450 2A6 CYP2A6 0.0023
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0023
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0023
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0023
4785 Ig gamma-1 chain C region IGHG1 0.0022
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0022
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0022
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0021
102 DNA topoisomerase I, mitochondrial TOP1MT 0.002
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0019
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0018
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0017
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0017
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0017
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0017
3927 Choline transporter-like protein 3 SLC44A3 0.0017
861 Choline kinase alpha CHKA 0.0017
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0017
769 High-affinity choline transporter 1 SLC5A7 0.0017
700 Choline dehydrogenase, mitochondrial CHDH 0.0017
1686 Choline transporter-like protein 1 SLC44A1 0.0017
3926 Choline transporter-like protein 2 SLC44A2 0.0017
3925 Choline transporter-like protein 4 SLC44A4 0.0017
576 Choline O-acetyltransferase CHAT 0.0017
3922 Phospholipase D2 PLD2 0.0017
3924 Phospholipase D1 PLD1 0.0017
1353 DNA topoisomerase 1 TOP1 0.0017
3552 DNA topoisomerase 1 topA 0.0017
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0017
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0017
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0017
4604 Liver carboxylesterase 1 CES1 0.0016
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0016
904 Glutathione S-transferase P GSTP1 0.0016
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0016
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0015
1898 Cytochrome P450 1B1 CYP1B1 0.0015
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0014
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0014
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0014
6163 Copper-transporting ATPase 2 ATP7B 0.0013
6165 Copper-transporting ATPase 1 ATP7A 0.0013
4498 Ornithine cyclodeaminase PP3533 0.0012
6146 High affinity copper uptake protein 1 SLC31A1 0.0012
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0012
5449 Hypothetical gliding protein mglB 0.0012
5443 UPF0189 protein ymdB ymdB 0.0012
5440 UPF0067 protein yebR yebR 0.0012
4705 Manganese catalase Not Available 0.0012
5439 33 kDa chaperonin hslO 0.0012
5446 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase HI_1679 0.0012
2720 Copper-containing nitrite reductase nirK 0.0012
5448 Ribonuclease Z rnz 0.0012
3781 Thiol:disulfide interchange protein dsbC precursor dsbC 0.0012
5447 Lethal(3)malignant brain tumor-like protein L3MBTL1 0.0012
5454 Internalin-A inlA 0.0012
332 Beta-lactamase blaZ 0.0012
2478 Beta-lactamase ampC 0.0012
2613 Beta-lactamase ampC 0.0012
2635 Beta-lactamase ampC 0.0012
2700 Beta-lactamase penP 0.0012
5445 Beta-lactamase blaB 0.0012
6019 Beta-lactamase SHV-7 0.0012
6701 Beta-lactamase cphA 0.0012
908 Glutathione S-transferase theta-1 GSTT1 0.0012
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0011
896 Glutathione S-transferase Mu 1 GSTM1 0.0011
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0011
5450 Prolyl endopeptidase Pep pep 0.0011
3356 Diaminopimelate decarboxylase lysA 0.001
6137 Multidrug resistance-associated protein 6 ABCC6 0.001
597 Dihydropteridine reductase QDPR 0.001
4771 Dissimilatory copper-containing nitrite reductase nir 0.001
862 Multidrug resistance-associated protein 1 ABCC1 0.001
3274 Hydroxylamine reductase hcp 0.001
4804 Hydroxylamine reductase hcp 0.001
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.001
2714 Chorismate mutase aroH 0.001
4611 Chorismate mutase aroG 0.001
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.001
3462 Tyrosine-protein kinase transforming protein Abl ABL 0.001
6136 Multidrug resistance-associated protein 5 ABCC5 0.001
3399 Limonene-1,2-epoxide hydrolase limA 0.001
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.001
1757 Myeloperoxidase MPO 0.001
4608 Putative cytochrome P450 SCO1207 0.0009
4963 Putative cytochrome P450 SCO2884 0.0009
6254 Putative cytochrome P450 SCO6998 0.0009
5180 L(+)-mandelate dehydrogenase mdlB 0.0009
577 Argininosuccinate lyase ASL 0.0009
3500 Putative family 31 glucosidase yicI yicI 0.0009
4878 Glycoprotein hormones alpha chain CGA 0.0009
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0009
1072 Granzyme B GZMB 0.0009
4889 Ig epsilon chain C region IGHE 0.0009
4877 Beta-mannanase man 0.0009
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0009
4189 Alpha-galactosidase A GLA 0.0009
4850 Beta-2-glycoprotein 1 APOH 0.0009
4880 Membrane cofactor protein CD46 0.0009
4856 CD209 antigen CD209 0.0009
1354 Beta-glucuronidase GUSB 0.0009
757 Fusion glycoprotein F0 F 0.0009
4875 Fusion glycoprotein F0 F 0.0009
4869 Major capsid protein A430L 0.0009
4852 Reticulon-4 receptor RTN4R 0.0009
4845 ADAM 33 ADAM33 0.0009
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0009
442 Envelope glycoprotein gp41 0.0009
4859 Envelope glycoprotein env 0.0009
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0009
4721 Beta-1,4-mannanase manA 0.0009
3352 Structural polyprotein Not Available 0.0009
3628 Structural polyprotein Not Available 0.0009
4892 Structural polyprotein Not Available 0.0009
1615 Chymase CMA1 0.0009
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0009
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.0008
365 Dihydrofolate reductase DHFR 0.0008
2381 Dihydrofolate reductase DFR1 0.0008
2833 Dihydrofolate reductase Not Available 0.0008
2931 Dihydrofolate reductase folA 0.0008
3544 Dihydrofolate reductase folA 0.0008
3682 Dihydrofolate reductase folA 0.0008
6642 Dihydrofolate reductase folA 0.0008
6756 Dihydrofolate reductase dfrA 0.0008
287 Beta-1,4-galactosyltransferase 1 B4GALT1 0.0008
4861 Interleukin-6 receptor alpha chain IL6R 0.0008
793 T-cell surface antigen CD2 CD2 0.0008
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0008
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0008
3837 Cytokine receptor common beta chain CSF2RB 0.0008
4890 Hemagglutinin HA 0.0007
6566 Hemagglutinin Not Available 0.0007
1379 Interleukin-12 subunit beta IL12B 0.0007
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0007
6858 Inactive carboxylesterase 4 CES1P1 0.0007
1184 Interferon beta IFNB1 0.0007
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0007
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0007
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0006
554 Low-density lipoprotein receptor LDLR 0.0006
852 Heparin cofactor 2 SERPIND1 0.0006
1859 Prostatic acid phosphatase ACPP 0.0006
3444 Cyanovirin-N Not Available 0.0006
3140 Hemagglutinin-neuraminidase HN 0.0006
3609 Hemagglutinin-neuraminidase HN 0.0006
595 Fibrinogen alpha chain FGA 0.0006
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0006
4666 Fucose-binding lectin PA-IIL lecB 0.0005
2372 Bifunctional tail protein 9 0.0005
958 Insulin-like growth factor 1 receptor IGF1R 0.0005
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0005
3814 Complement C1r subcomponent C1R 0.0005
64 Neuraminidase NA 0.0005
641 Neuraminidase NA 0.0005
2676 Neuraminidase NA 0.0005
3026 Neuraminidase NA 0.0005
3519 Neuraminidase NA 0.0005
6007 Neuraminidase NA 0.0005
1243 Cathepsin D CTSD 0.0005
1439 Lactotransferrin LTF 0.0005
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0005
309 Antithrombin-III SERPINC1 0.0005
2430 Chondroitinase B cslB 0.0004
6307 Ig gamma-2 chain C region IGHG2 0.0004
2581 Chondroitinase AC cslA 0.0004
6847 Lactase-phlorizin hydrolase LCT 0.0004
6500 Phospholipase A2 PLA2G1B 0.0004
76 Nitric-oxide synthase, brain NOS1 0.0003
952 Dipeptidyl peptidase 4 DPP4 0.0003
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