Identification | |
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Name | Metixene |
Accession Number | DB00340 (APRD01101) |
Type | small molecule |
Description | Metixene (or methixene) is a anticholinergic used as an anti-parkinson drug. [Wikipedia] |
Structure |
|
Categories (*) | |
Molecular Weight | 309.468 |
Groups | approved |
Monoisotopic Weight | 309.155120431 |
Pharmacology | |
Indication | Used for the symptomatic treatment of parkinsonism. |
Mechanism of action | Parkinsonism is thought to result from an imbalance between the excitatory (cholinergic) and inhibitory (dopaminergic) systems in the corpus striatum. The mechanism of action of centrally active anticholinergic drugs such as metixene is considered to relate to competitive antagonism of acetylcholine at muscarinic receptors in the corpus striatum, which then restores the balance. |
Absorption | Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known. |
Protein binding | Not Available |
Biotransformation | Hepatic. Metabolism occurs via sulfoxydation and N-demethylation. |
Route of elimination | Not Available |
Toxicity | Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures. |
Affected organisms |
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Interactions | |
Drug Interactions | Not Available |
Food Interactions | Not Available |
Muscarinic acetylcholine receptor M1 | |
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Name | Muscarinic acetylcholine receptor M1 |
Gene Name | CHRM1 |
Pharmacological action | yes |
Actions | antagonist |
References | |
DTHybrid score | 0.8625 |
Muscarinic acetylcholine receptor M4 | |
Name | Muscarinic acetylcholine receptor M4 |
Gene Name | CHRM4 |
Pharmacological action | yes |
Actions | antagonist |
References | |
DTHybrid score | 0.5385 |
Muscarinic acetylcholine receptor M5 | |
Name | Muscarinic acetylcholine receptor M5 |
Gene Name | CHRM5 |
Pharmacological action | yes |
Actions | antagonist |
References |
|
DTHybrid score | 0.4382 |
Muscarinic acetylcholine receptor M2 | |
Name | Muscarinic acetylcholine receptor M2 |
Gene Name | CHRM2 |
Pharmacological action | unknown |
Actions | antagonist |
References | |
DTHybrid score | 0.7545 |
Muscarinic acetylcholine receptor M3 | |
Name | Muscarinic acetylcholine receptor M3 |
Gene Name | CHRM3 |
Pharmacological action | unknown |
Actions | antagonist |
References | |
DTHybrid score | 0.7578 |