Identification | |
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Name | Cefmenoxime |
Accession Number | DB00267 (APRD00851) |
Type | small molecule |
Description | Cefmenoxime is a third-generation cephalosporin antibiotic. [Wikipedia] |
Structure |
|
Categories (*) | |
Molecular Weight | 511.558 |
Groups | approved |
Monoisotopic Weight | 511.051476769 |
Pharmacology | |
Indication | Used to treat female gynecologic and obstetric infections caused by susceptible aerobic (including the gonococcus) and anaerobic bacteria. |
Mechanism of action | The bactericidal activity of cefmenoxime results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). Cefmenoxime is stable in the presence of a variety of b-lactamases, including penicillinases and some cephalosporinases. |
Absorption | Bioavailability is approximately 100% following intramuscular injection. |
Protein binding | 50-70% |
Biotransformation | Not appreciably metabolized. |
Route of elimination | Not Available |
Toxicity | Information on cefmenoxime overdosage in humans is not available. However, with other b-lactam antibiotics, adverse effects following overdosage have included nausea, vomiting, epigastric distress, diarrhea, and convulsions. |
Affected organisms |
|
Interactions | |
Drug Interactions | Not Available |
Food Interactions | Not Available |
Penicillin-binding proteins 1A/1B | |
---|---|
Name | Penicillin-binding proteins 1A/1B |
Gene Name | pbpA |
Pharmacological action | yes |
Actions | inhibitor |
References |
|
DTHybrid score | 0.7833 |
Peptidoglycan synthetase ftsI | |
Name | Peptidoglycan synthetase ftsI |
Gene Name | ftsI |
Pharmacological action | yes |
Actions | inhibitor |
References |
|
DTHybrid score | 0.019 |