DT-Web

DB00249 - Idoxuridine


Identification
Name Idoxuridine
Accession Number DB00249 (APRD00504, DB03778, EXPT01835)
Type small molecule
Description An analog of deoxyuridine that inhibits viral DNA synthesis. The drug is used as an antiviral agent. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 354.0985
Groups approved
Monoisotopic Weight 353.971264892
Pharmacology
Indication For use in keratoconjunctivitis and keratitis caused by herpes simplex virus.
Mechanism of action Idoxuridine acts as an antiviral agent by inhibiting viral replication by substituting itself for thymidine in viral DNA. This in turn inhibits thymidylate phosphorylase and viral DNA polymerases from properly functioning. The effect of Idoxuridine results in the inability of the virus to reproduce or to infect/destroy tissue.
Absorption Systemic absorption is unlikely following ocular administration even when nasolacrimal secretions are swallowed, since vidarabine is rapidly deaminated in the gastrointestinal tract.
Protein binding Not Available
Biotransformation Idoxuridine is rapidly inactivated by deaminases or nucleotidases.
Route of elimination Not Available
Toxicity Hypersensitivity or increased sensitivity of eyes to light. LD50=3080 mg/kg (orally in mice).
Affected organisms
  • Herpes simplex virus
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


DNA
Name DNA
Gene Name Not Available
Pharmacological action yes
Actions other
References
  • Komissarova NV, Tiunova AA, Anokhin KV: Selective impairments to memory consolidation in chicks produced by 5'-iodo-2'-deoxyuridine. Neurosci Behav Physiol. 2010 Feb;40(2):215-23. Epub 2009 Dec 22. - Pubmed
  • Komissarova NV, Tiunova AA, Anokhin KV: [Selective disruption of memory consolidation in chicks produced by 5'-iodo-2'-deoxyuridine] Zh Vyssh Nerv Deiat Im I P Pavlova. 2008 Nov-Dec;58(6):700-10. - Pubmed
DTHybrid score Not Available
Thymidine kinase
Name Thymidine kinase
Gene Name TK
Pharmacological action unknown
Actions unknown
References
  • Wild K, Bohner T, Folkers G, Schulz GE: The structures of thymidine kinase from herpes simplex virus type 1 in complex with substrates and a substrate analogue. Protein Sci. 1997 Oct;6(10):2097-106. - Pubmed
DTHybrid score 0.8307

Predictions


Id Partner name Gene Name Score
570 Thymidine kinase TK 0.8307
2559 Thymidine kinase TK 0.8307
3430 Thymidine kinase tdk 0.8307
3518 Thymidine kinase TK 0.8307
5301 Thymidine kinase tdk 0.8307
5771 Thymidine kinase ORF36 0.8307
7009 Thymidine kinase ORF36 0.8307
3957 Adenosine deaminase ADA 0.0908
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0481
338 DNA polymerase UL30 0.0464
379 DNA polymerase UL54 0.0464
697 DNA polymerase ORF28 0.0464
2482 DNA polymerase 43 0.0464
4104 DNA polymerase BALF5 0.0464
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0388
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0261
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.025
6142 Solute carrier family 22 member 8 SLC22A8 0.0236
1729 Solute carrier family 22 member 6 SLC22A6 0.022
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