DT-Web

DB00212 - Remikiren


Identification
Name Remikiren
Accession Number DB00212 (APRD00163)
Type small molecule
Description Remikiren is an orally active, high specificity renin inhibitor.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 630.838
Groups approved
Monoisotopic Weight 630.345106042
Pharmacology
Indication For the treatment of hypertension and heart failure
Mechanism of action Several in vivo experiments have shown that remikiren is specific for renin and does not decrease arterial pressure by an unrelated mechanism.
Absorption Absorbed following oral administration.
Protein binding 83%
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Renin
Name Renin
Gene Name REN
Pharmacological action yes
Actions inhibitor
References
  • van Paassen P, Navis GJ, De Jong PE, De Zeeuw D: Pretreatment renal vascular tone predicts the effect of specific renin inhibition on natriuresis in essential hypertension. Eur J Clin Invest. 1999 Dec;29(12):1019-26. - Pubmed
  • MacFadyen RJ, Jones CR, Doig JK, Birnbock H, Reid JL: Responses to an orally active renin inhibitor, remikiren (Ro 42-5892), after controlled salt depletion in humans. J Cardiovasc Pharmacol. 1995 Mar;25(3):347-53. - Pubmed
  • Kiowski W, Beermann J, Rickenbacher P, Haemmerli R, Thomas M, Burkart F, Meinertz T: Angiotensinergic versus nonangiotensinergic hemodynamic effects of converting enzyme inhibition in patients with chronic heart failure. Assessment by acute renin and converting enzyme inhibition. Circulation. 1994 Dec;90(6):2748-56. - Pubmed
  • Hilgers KF, Fischli W, Veelken R, Mann JF: Vascular renin in the guinea pig. Suppression by the renin inhibitor remikiren. Hypertension. 1994 Jun;23(6 Pt 2):861-4. - Pubmed
  • Clozel JP, Fischli W: Comparative effects of three different potent renin inhibitors in primates. Hypertension. 1993 Jul;22(1):9-17. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.6659

Predictions


Id Partner name Gene Name Score
3180 Candidapepsin-2 SAP2 0.0586
6260 Chymotrypsin-like elastase family member 1 CELA1 0.0459
291 Nitric-oxide synthase, endothelial NOS3 0.0367
4512 Cytochrome P450 3A4 CYP3A4 0.0164
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