DT-Web

DB00147 - Pyridoxal


Identification
Name Pyridoxal
Accession Number DB00147 (NUTR00049)
Type small molecule
Description The 4-carboxyaldehyde form of vitamin B 6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 167.162
Groups approved
Monoisotopic Weight 167.058243159
Pharmacology
Indication Pyridoxal is one of the natural forms available of vitamin B6, therefore, it is used for nutritional supplementation and for treating dietary shortage or imbalances.
Mechanism of action Pyridoxal is the precursor to pyridoxal phosphate. Pyridoxal 5'-phosphate is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA).
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Oral LD50 Rat: 2150 mg/kg, Oral LD50 Mouse: 1800 mg/kg
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Pyridoxal kinase
Name Pyridoxal kinase
Gene Name PDXK
Pharmacological action yes
Actions Not Available
References
  • Tang L, Li MH, Cao P, Wang F, Chang WR, Bach S, Reinhardt J, Ferandin Y, Galons H, Wan Y, Gray N, Meijer L, Jiang T, Liang DC: Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives. J Biol Chem. 2005 Sep 2;280(35):31220-9. Epub 2005 Jun 28. - Pubmed
  • Adams JB, George F, Audhya T: Abnormally high plasma levels of vitamin B6 in children with autism not taking supplements compared to controls not taking supplements. J Altern Complement Med. 2006 Jan-Feb;12(1):59-63. - Pubmed
  • Newman JA, Das SK, Sedelnikova SE, Rice DW: The crystal structure of an ADP complex of Bacillus subtilis pyridoxal kinase provides evidence for the parallel emergence of enzyme activity during evolution. J Mol Biol. 2006 Oct 20;363(2):520-30. Epub 2006 Aug 12. - Pubmed
DTHybrid score 1.0651

Predictions


Id Partner name Gene Name Score
6024 Cytochrome P450 1A1 CYP1A1 0.0588
5312 Kinesin-like protein KIF1A KIF1A 0.0258
2615 Chemotaxis protein cheA cheA 0.0241
3669 Ribokinase rbsK 0.024
5466 Putative sugar kinase STM4066 0.0239
2878 Probable serine/threonine-protein kinase pknB pknB 0.0238
2621 Thermoresistant gluconokinase gntK 0.0237
4517 Probable butyrate kinase 2 buk2 0.0237
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.023
2299 UDP-N-acetylmuramate--L-alanine ligase murC 0.0219
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0219
2717 Folylpolyglutamate synthase fgs 0.0197
36 Insulin receptor INSR 0.0189
3199 Phosphopantetheine adenylyltransferase coaD 0.0038
3543 Phosphopantetheine adenylyltransferase coaD 0.0038
3567 Phosphopantetheine adenylyltransferase coaD 0.0038
5289 Phosphopantetheine adenylyltransferase coaD 0.0038
5288 Shikimate kinase aroK 0.0038
5304 UPF0166 protein TM_0021 TM_0021 0.0038
5287 Signaling protein Not Available 0.0038
5292 Putative partitioning protein TT_C1605 0.0038
5266 Activator of hgdC 0.0038
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0038
5259 Transcriptional regulator ntrC1 0.0038
6699 Transcriptional regulator Cgl2612 0.0038
2874 Nitrogenase iron protein 1 nifH1 0.0038
4346 Polynucleotide kinase pseT 0.0038
5293 Shikimate kinase 2 aroL 0.0038
5281 Plasmid segregation protein parM parM 0.0038
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0038
5276 Chromosomal replication initiator protein dnaA dnaA 0.0038
5315 Chaperone protein htpG htpG 0.0038
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0038
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0038
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0038
5291 Glycogen synthase 1 glgA1 0.0038
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0038
5283 D-alanine--D-alanine ligase B ddlB 0.0038
5284 Large T antigen Not Available 0.0038
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0038
5285 Kinesin heavy chain KIF5B 0.0038
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0038
5299 D-alanine--D-alanine ligase ddl 0.0038
6598 D-alanine--D-alanine ligase ddl 0.0038
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0038
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0038
5261 Phosphoribosylformylglycinamidine synthase purL 0.0038
5277 Preprotein translocase subunit secA secA 0.0038
5308 Preprotein translocase secA 1 subunit secA1 0.0038
5264 DNA replication protein REP 0.0038
4774 NTPase P4 Not Available 0.0031
5646 Galactokinase GALK1 0.0031
5265 FtsH ftsH 0.0031
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0031
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0031
5302 TrwB trwB 0.0031
6277 Heat shock cognate 71 kDa protein HSPA8 0.0031
3470 Hypothetical protein MG245 homolog MPN_348 0.0031
4838 PMS1 protein homolog 2 PMS2 0.0031
4837 Cag-alfa cag-alfa 0.0031
4839 DNA polymerase III subunit tau dnaX 0.0031
4106 Guanylate kinase GUK1 0.0031
4516 Guanylate kinase gmk 0.0031
5189 Trimethylamine dehydrogenase tmd 0.0031
413 Amidophosphoribosyltransferase PPAT 0.0031
2515 Amidophosphoribosyltransferase purF 0.0031
3714 Amidophosphoribosyltransferase purF 0.0031
2270 Dephospho-CoA kinase coaE 0.0031
2284 Adenylate kinase adk 0.0031
2296 Adenylate kinase adk 0.0031
2311 Adenylate kinase adk 0.0031
2312 Adenylate kinase Not Available 0.0031
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0031
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0031
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0031
3175 Glutamate--cysteine ligase gshA 0.0031
3426 Glutamine synthetase glnA 0.0031
3987 Glutamine synthetase GLUL 0.0031
2683 Mono-ADP-ribosyltransferase C3 C3 0.0029
340 Apoptotic protease-activating factor 1 APAF1 0.0029
2390 Nonsecretory ribonuclease RNASE2 0.0028
5300 Antigen peptide transporter 1 TAP1 0.0028
5271 Focal adhesion kinase 1 PTK2 0.0028
2922 Glycerol kinase glpK 0.0028
2282 Protein recA recA 0.0027
2315 Protein recA recA 0.0027
2332 Protein recA recA 0.0027
5263 Protein recA recA 0.0027
408 Riboflavin kinase RFK 0.0027
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0026
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0026
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0026
2371 Pantothenate kinase coaA 0.0026
1881 Hexokinase-1 HK1 0.0026
2892 Acetylglutamate kinase argB 0.0026
3550 Acetylglutamate kinase argB 0.0026
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0026
825 Arsenical pump-driving ATPase ASNA1 0.0026
3435 Arsenical pump-driving ATPase arsA 0.0026
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0025
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0025
2727 S-adenosylmethionine synthetase metK 0.0025
788 Creatine kinase M-type CKM 0.0025
2697 Uridine-cytidine kinase 2 UCK2 0.0024
2334 Dethiobiotin synthetase bioD 0.0024
6555 Dethiobiotin synthetase bioD 0.0024
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0023
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0023
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0023
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0022
702 UMP-CMP kinase CMPK1 0.0022
6395 Myosin-14 MYH14 0.0022
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0022
2091 Endoplasmin HSP90B1 0.0022
2251 Thymidylate kinase tmk 0.0022
2254 Thymidylate kinase DTYMK 0.0022
3522 Thymidylate kinase tmk 0.0022
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0021
207 Glutathione synthetase GSS 0.0021
5269 Glutathione synthetase gshB 0.0021
1422 Serine/threonine-protein kinase 6 AURKA 0.0021
3379 Kinesin-like protein KIF11 KIF11 0.0021
3456 Heat shock protein HSP 90-beta HSP90AB1 0.002
3822 Actin, alpha skeletal muscle ACTA1 0.002
504 Mast/stem cell growth factor receptor KIT 0.002
509 Thymidine kinase TK 0.0019
570 Thymidine kinase TK 0.0019
2559 Thymidine kinase TK 0.0019
3430 Thymidine kinase tdk 0.0019
3518 Thymidine kinase TK 0.0019
5301 Thymidine kinase tdk 0.0019
5771 Thymidine kinase ORF36 0.0019
7009 Thymidine kinase ORF36 0.0019
5294 Nucleoside diphosphate kinase A NME1 0.0019
1721 Glycogen synthase kinase-3 beta GSK3B 0.0018
4773 Deoxycytidine kinase DCK 0.0018
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0017
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0017
5682 Ribonuclease pancreatic RNASE1 0.0017
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0016
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