DT-Web

DB00113 - Arcitumomab


Identification
Name Arcitumomab
Accession Number DB00113 (BIOD00107, BTD00107)
Type biotech
Description Reduced Fab fragment of the murine IgG1 monoclonal antibody IMMU-4 (also called NP-4) with specificity for carcinoembryonic antigen (CEA) covalently labeled with Technitium 99. The molecule has a molecular weight of ~54,000 Daltons.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 144482.5000
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication For imaging colorectal tumors
Mechanism of action Binds selectively to cell-surface carcinoembryonic antigen (CEA) expressed on colorectal tumors.
Absorption Not Available
Protein binding Not Available
Biotransformation Most likely removed by opsonization via the reticuloendothelial system, or by human antimurine antibody production
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Carcinoembryonic antigen-related cell adhesion molecule 1
Name Carcinoembryonic antigen-related cell adhesion molecule 1
Gene Name CEACAM1
Pharmacological action unknown
Actions other/unknown
References
  • Fuster D, Maurel J, Muxi A, Setoain X, Ayuso C, Martin F, Ortega ML, Fuertes S, Pons F: Is there a role for (99m)Tc-anti-CEA monoclonal antibody imaging in the diagnosis of recurrent colorectal carcinoma? Q J Nucl Med. 2003 Jun;47(2):109-15. - Pubmed
  • Hughes K, Pinsky CM, Petrelli NJ, Moffat FL, Patt YZ, Hammershaimb L, Goldenberg DM: Use of carcinoembryonic antigen radioimmunodetection and computed tomography for predicting the resectability of recurrent colorectal cancer. Ann Surg. 1997 Nov;226(5):621-31. - Pubmed
DTHybrid score 1.0152

Predictions


Id Partner name Gene Name Score
4878 Glycoprotein hormones alpha chain CGA 0.0148
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0148
1072 Granzyme B GZMB 0.0148
4880 Membrane cofactor protein CD46 0.0148
4877 Beta-mannanase man 0.0148
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0148
4850 Beta-2-glycoprotein 1 APOH 0.0148
757 Fusion glycoprotein F0 F 0.0148
4875 Fusion glycoprotein F0 F 0.0148
4856 CD209 antigen CD209 0.0148
4889 Ig epsilon chain C region IGHE 0.0148
4189 Alpha-galactosidase A GLA 0.0148
4869 Major capsid protein A430L 0.0148
4852 Reticulon-4 receptor RTN4R 0.0148
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0148
1354 Beta-glucuronidase GUSB 0.0148
442 Envelope glycoprotein gp41 0.0148
4859 Envelope glycoprotein env 0.0148
3352 Structural polyprotein Not Available 0.0148
3628 Structural polyprotein Not Available 0.0148
4892 Structural polyprotein Not Available 0.0148
4845 ADAM 33 ADAM33 0.0148
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0148
4721 Beta-1,4-mannanase manA 0.0148
6858 Inactive carboxylesterase 4 CES1P1 0.0129
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0129
1379 Interleukin-12 subunit beta IL12B 0.0129
1184 Interferon beta IFNB1 0.0129
793 T-cell surface antigen CD2 CD2 0.0129
4861 Interleukin-6 receptor alpha chain IL6R 0.0129
4890 Hemagglutinin HA 0.0129
6566 Hemagglutinin Not Available 0.0129
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0129
554 Low-density lipoprotein receptor LDLR 0.0129
3837 Cytokine receptor common beta chain CSF2RB 0.0129
3444 Cyanovirin-N Not Available 0.0119
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0119
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0119
1859 Prostatic acid phosphatase ACPP 0.0119
852 Heparin cofactor 2 SERPIND1 0.0119
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0119
3140 Hemagglutinin-neuraminidase HN 0.0119
3609 Hemagglutinin-neuraminidase HN 0.0119
2297 Genome polyprotein Not Available 0.0119
2322 Genome polyprotein Not Available 0.0119
2694 Genome polyprotein Not Available 0.0119
2719 Genome polyprotein Not Available 0.0119
2860 Genome polyprotein Not Available 0.0119
2928 Genome polyprotein Not Available 0.0119
3160 Genome polyprotein Not Available 0.0119
3260 Genome polyprotein Not Available 0.0119
4783 Genome polyprotein Not Available 0.0119
5726 Genome polyprotein Not Available 0.0119
5779 Genome polyprotein Not Available 0.0119
5867 Genome polyprotein Not Available 0.0119
6253 Genome polyprotein Not Available 0.0119
6301 Genome polyprotein Not Available 0.0119
6380 Genome polyprotein Not Available 0.0119
6381 Genome polyprotein Not Available 0.0119
6437 Genome polyprotein Not Available 0.0119
6520 Genome polyprotein Not Available 0.0119
6521 Genome polyprotein Not Available 0.0119
6652 Genome polyprotein Not Available 0.0119
6734 Genome polyprotein Not Available 0.0119
6735 Genome polyprotein Not Available 0.0119
6736 Genome polyprotein Not Available 0.0119
6737 Genome polyprotein Not Available 0.0119
6738 Genome polyprotein Not Available 0.0119
6739 Genome polyprotein Not Available 0.0119
6744 Genome polyprotein Not Available 0.0119
6748 Genome polyprotein Not Available 0.0119
6894 Genome polyprotein Not Available 0.0119
6898 Genome polyprotein Not Available 0.0119
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0119
4666 Fucose-binding lectin PA-IIL lecB 0.0112
4787 Envelope glycoprotein gp160 env 0.0112
4820 Envelope glycoprotein gp160 env 0.0112
5727 Envelope glycoprotein gp160 env 0.0112
2372 Bifunctional tail protein 9 0.0112
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0107
3480 Mannan endo-1,4-beta-mannosidase manA 0.0104
64 Neuraminidase NA 0.0104
641 Neuraminidase NA 0.0104
2676 Neuraminidase NA 0.0104
3026 Neuraminidase NA 0.0104
3519 Neuraminidase NA 0.0104
6007 Neuraminidase NA 0.0104
595 Fibrinogen alpha chain FGA 0.0103
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.01
1439 Lactotransferrin LTF 0.01
1243 Cathepsin D CTSD 0.0098
2430 Chondroitinase B cslB 0.0095
958 Insulin-like growth factor 1 receptor IGF1R 0.0095
2581 Chondroitinase AC cslA 0.0094
309 Antithrombin-III SERPINC1 0.0094
6307 Ig gamma-2 chain C region IGHG2 0.0094
6847 Lactase-phlorizin hydrolase LCT 0.0093
6500 Phospholipase A2 PLA2G1B 0.009
2207 Rhodopsin RHO 0.0087
3814 Complement C1r subcomponent C1R 0.0082
4785 Ig gamma-1 chain C region IGHG1 0.0078
4604 Liver carboxylesterase 1 CES1 0.0078
76 Nitric-oxide synthase, brain NOS1 0.0077
952 Dipeptidyl peptidase 4 DPP4 0.0067
3923 Cholinesterase BCHE 0.0064
20 Prostaglandin G/H synthase 1 PTGS1 0.0059
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