DT-Web

DB00107 - Oxytocin


Identification
Name Oxytocin
Accession Number DB00107 (BIOD00016, BTD00016)
Type biotech
Description Synthetic 9 residue cyclic peptide. The hormone is prepared synthetically to avoid possible contamination with vasopressin (ADH) and other small polypeptides with biologic activity.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 1007.1870
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication To assist in labor, elective labor induction, uterine contraction induction
Mechanism of action Binds the oxytocin receptor which leads to an increase in intracellular calcium levels. The oxytocin-oxytocin receptor system plays an important role as an inducer of uterine contractions during parturition and of milk ejection.
Absorption Not Available
Protein binding 30%
Biotransformation hepatic oxytocinases
Route of elimination Biliary and renal
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Epinephrine Possible marked increase of arterial pressure
Phenylephrine Possible marked increase of arterial pressure
Food Interactions Not Available

Targets


Oxytocin receptor
Name Oxytocin receptor
Gene Name OXTR
Pharmacological action yes
Actions agonist
References
  • Spyranti Z, Fragiadaki M, Magafa V, Borovickova L, Spyroulias GA, Cordopatis P, Slaninova J: In position 7 L- and D-Tic-substituted oxytocin and deamino oxytocin: NMR study and conformational insights. Amino Acids. 2010 Jul;39(2):539-48. Epub 2010 Jan 27. - Pubmed
  • Frantz MC, Rodrigo J, Boudier L, Durroux T, Mouillac B, Hibert M: Subtlety of the structure-affinity and structure-efficacy relationships around a nonpeptide oxytocin receptor agonist. J Med Chem. 2010 Feb 25;53(4):1546-62. - Pubmed
  • Gimpl G, Reitz J, Brauer S, Trossen C: Oxytocin receptors: ligand binding, signalling and cholesterol dependence. Prog Brain Res. 2008;170:193-204. - Pubmed
  • Ahn TG, Han SJ, Cho YS, An TH, Pak SC, Flouret G: In vivo activity of the potent oxytocin antagonist on uterine activity in the rat. In Vivo. 2004 Nov-Dec;18(6):763-6. - Pubmed
  • Furman DJ, Chen MC, Gotlib IH: Variant in oxytocin receptor gene is associated with amygdala volume. Psychoneuroendocrinology. 2011 Jan 3. - Pubmed
DTHybrid score 1.8991
Oxytocin-neurophysin 1
Name Oxytocin-neurophysin 1
Gene Name OXT
Pharmacological action unknown
Actions binder
References
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Land H, Grez M, Ruppert S, Schmale H, Rehbein M, Richter D, Schutz G: Deduced amino acid sequence from the bovine oxytocin-neurophysin I precursor cDNA. Nature. 1983 Mar 24-30;302(5906):342-4. - Pubmed
  • Rao VV, Loffler C, Battey J, Hansmann I: The human gene for oxytocin-neurophysin I (OXT) is physically mapped to chromosome 20p13 by in situ hybridization. Cytogenet Cell Genet. 1992;61(4):271-3. - Pubmed
DTHybrid score 1.0911

Enzymes


Prolyl endopeptidase
Name Prolyl endopeptidase
Gene Name PREP
Actions substrate
References
  • Irazusta J, Silveira PF, Gil J, Varona A, Casis L: Effects of hydrosaline treatments on prolyl endopeptidase activity in rat tissues. Regul Pept. 2001 Sep 15;101(1-3):141-7. - Pubmed
  • Bausback HH, Ward PE: Vascular, post proline cleaving enzyme: metabolism of vasoactive peptides. Adv Exp Med Biol. 1986;198 Pt A:397-404. - Pubmed
  • Yoshimoto T, Nishimura T, Kita T, Tsuru D: Post-proline cleaving enzyme (prolyl endopeptidase) from bovine brain. J Biochem. 1983 Oct;94(4):1179-90. - Pubmed
DTHybrid score 1.8847

Predictions


Id Partner name Gene Name Score
6928 Prolyl endopeptidase Not Available 1.8847
5241 Probable thiol peroxidase tpx 0.042
5239 Exopolyphosphatase ppx 0.042
4037 Hypothetical protein GPX1 0.0419
4297 Hypothetical protein SP_1951 0.0419
4521 Hypothetical protein BC_2969 0.0419
4540 Hypothetical protein TM_1070 0.0419
4555 Hypothetical protein MT1739 0.0419
4569 Hypothetical protein mshD 0.0419
4578 Hypothetical protein PA3270 0.0419
4747 Hypothetical protein PA3967 0.0419
5177 Hypothetical protein TM_0096 0.0419
5194 Hypothetical protein PA1204 0.0419
5240 Hypothetical protein Rv2991 0.0419
5370 Hypothetical protein TM_1158 0.0419
5710 Hypothetical protein Tb927.5.1360 0.0419
2750 Aspartate 1-decarboxylase panD 0.0365
4440 NADH peroxidase npr 0.0337
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0218
4340 Hypothetical conserved protein GK2698 0.021
6484 Hypothetical conserved protein TT_C0834 0.021
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.021
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.021
1434 Protein DJ-1 PARK7 0.021
4341 Beta crystallin B1 CRYBB1 0.021
4339 Sucrose phosphorylase sucP 0.021
2688 Peptide deformylase def 0.0183
2708 Peptide deformylase def 0.0183
3004 Peptide deformylase def 0.0183
4337 Peptide deformylase def 0.0183
4338 Peptide deformylase def 0.0183
5368 Peptide deformylase def 0.0183
5371 Peptide deformylase def 0.0183
6375 Peptide deformylase def 0.0183
6378 Peptide deformylase def 0.0183
6379 Peptide deformylase def 0.0183
6776 Peptide deformylase def 0.0183
6900 Peptide deformylase def 0.0183
3421 Hydroxyethylthiazole kinase thiM 0.0183
4343 Alpha-glucosidase aglA 0.0168
3105 M-phase inducer phosphatase 2 CDC25B 0.0168
2840 Beta-lactamase IMP-1 Not Available 0.0147
687 Tyrosine-protein phosphatase non-receptor type 1 PTPN1 0.0093
2240 Cell division protein kinase 2 CDK2 0.0078
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