DT-Web

DB00102 - Becaplermin


Identification
Name Becaplermin
Accession Number DB00102 (BIOD00053, BTD00053)
Type biotech
Description Becaplermin is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet derived growth factor (PDGF) into the yeast, Saccharomyces cerevisiae. Becaplermin has a molecular weight of approximately 25 KD and is a homodimer composed of two identical polypeptide chains that are bound together by disulfide bonds
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 12294.4000
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication For topical treatment of skin ulcers (from diabetes)
Mechanism of action Binds to the beta platelet-derived growth factor (PDGF) receptor, a tyrosine kinase receptor. PDGF is known to exist as a dimer, and activates its signaling pathway by a ligand induced receptor dimerization and autophosphorylation. PDGF receptors also contain many auto-phosphorylation sites, which serve to mediate binding of SH2 sites and subsequently signal corresponding pathways. There are five different isoforms of PDGF that activate through two different receptors (alpha and beta).
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Beta platelet-derived growth factor receptor
Name Beta platelet-derived growth factor receptor
Gene Name PDGFRB
Pharmacological action yes
Actions Not Available
References
  • Papanas N, Maltezos E: Becaplermin gel in the treatment of diabetic neuropathic foot ulcers. Clin Interv Aging. 2008;3(2):233-40. - Pubmed
DTHybrid score 0.4173
Alpha platelet-derived growth factor receptor
Name Alpha platelet-derived growth factor receptor
Gene Name PDGFRA
Pharmacological action unknown
Actions Not Available
References
  • Abdiu A, Walz TM, Nishikawa BK, Wingren S, Larsson SE, Wasteson A: Human malignant fibrous histiocytomas in vitro: growth characteristics and their association with expression of mRNA for platelet-derived growth factor, transforming growth factor-alpha and their receptors. Eur J Cancer. 1998 Dec;34(13):2094-100. - Pubmed
  • Ebert M, Yokoyama M, Friess H, Kobrin MS, Buchler MW, Korc M: Induction of platelet-derived growth factor A and B chains and over-expression of their receptors in human pancreatic cancer. Int J Cancer. 1995 Sep 4;62(5):529-35. - Pubmed
  • Miller-Kasprzak E, Niemir ZI, Czekalski S: [Structure and function of PDGF-R-alpha and its expression in normal kidney and kidney diseases] Przegl Lek. 2002;59(10):826-31. - Pubmed
  • Heidaran MA, Pierce JH, Lombardi D, Ruggiero M, Gutkind JS, Matsui T, Aaronson SA: Deletion or substitution within the alpha platelet-derived growth factor receptor kinase insert domain: effects on functional coupling with intracellular signaling pathways. Mol Cell Biol. 1991 Jan;11(1):134-42. - Pubmed
  • Yu J, Liu XW, Kim HR: Platelet-derived growth factor (PDGF) receptor-alpha-activated c-Jun NH2-terminal kinase-1 is critical for PDGF-induced p21WAF1/CIP1 promoter activity independent of p53. J Biol Chem. 2003 Dec 5;278(49):49582-8. Epub 2003 Sep 23. - Pubmed
DTHybrid score 0.4324
Alpha-2-macroglobulin
Name Alpha-2-macroglobulin
Gene Name A2M
Pharmacological action unknown
Actions Not Available
References
  • Lizonova A, Bizik J, Grofova M, Vaheri A: Coexpression of tumor-associated alpha 2-macroglobulin and growth factors in human melanoma cell lines. J Cell Biochem. 1990 Aug;43(4):315-25. - Pubmed
  • Bonner JC, Osornio-Vargas AR: Differential binding and regulation of platelet-derived growth factor A and B chain isoforms by alpha 2-macroglobulin. J Biol Chem. 1995 Jul 7;270(27):16236-42. - Pubmed
DTHybrid score 0.9595

Predictions


Id Partner name Gene Name Score
2155 Insulin-degrading enzyme IDE 0.2835
1952 Alpha-2-antiplasmin SERPINF2 0.2355
2146 Fibronectin FN1 0.2354
504 Mast/stem cell growth factor receptor KIT 0.1108
26 Vascular endothelial growth factor receptor 3 FLT4 0.0866
32 Vascular endothelial growth factor receptor 1 FLT1 0.0836
407 Vascular endothelial growth factor receptor 2 KDR 0.0768
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.063
165 FL cytokine receptor FLT3 0.0541
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0503
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0492
1588 Multidrug resistance protein 1 ABCB1 0.0488
3856 Fibroblast growth factor receptor 3 FGFR3 0.0467
4512 Cytochrome P450 3A4 CYP3A4 0.043
1618 High affinity nerve growth factor receptor NTRK1 0.0388
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0387
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0366
4118 Cytochrome P450 3A5 CYP3A5 0.0345
5787 Angiopoietin-1 receptor TEK 0.0329
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0327
936 Ephrin type-A receptor 2 EPHA2 0.0324
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0318
823 Fibroblast growth factor receptor 2 FGFR2 0.03
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0296
4924 Cytochrome P450 2C8 CYP2C8 0.0274
5798 Mitogen-activated protein kinase 11 MAPK11 0.0265
4200 Cytochrome P450 1A2 CYP1A2 0.0263
6107 Cytochrome P450 3A7 CYP3A7 0.0259
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.025
4119 Cytochrome P450 2D6 CYP2D6 0.025
1864 RET proto-oncogene RET 0.0242
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0241
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0241
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.024
760 Fibroblast growth factor 1 FGF1 0.023
2164 Multidrug resistance-associated protein 4 ABCC4 0.022
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0195
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0193
6016 Cytochrome P450 2C19 CYP2C19 0.0185
4757 Cytochrome P450 2C9 CYP2C9 0.0177
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0168
2216 Fibroblast growth factor receptor 4 FGFR4 0.0159
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0154
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0148
1063 Signal transducer and activator of transcription 5B STAT5B 0.0148
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0143
6824 Tyrosine-protein kinase Lyn LYN 0.0137
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0131
6030 Cytochrome P450 2B6 CYP2B6 0.0122
484 Tyrosine-protein kinase ABL2 ABL2 0.0118
1181 Alpha-1-acid glycoprotein 1 ORM1 0.011
6144 Solute carrier family 22 member 2 SLC22A2 0.0099
6145 Solute carrier family 22 member 1 SLC22A1 0.0096
20 Prostaglandin G/H synthase 1 PTGS1 0.0093
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.009
587 Serum albumin ALB 0.0087
1898 Cytochrome P450 1B1 CYP1B1 0.0069
776 Bile salt export pump ABCB11 0.0068
6024 Cytochrome P450 1A1 CYP1A1 0.0056
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