Identification | |
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Name | Choriogonadotropin alfa |
Accession Number | DB00097 (BIOD00034, BTD00034) |
Type | biotech |
Description | Recombinant human chorionic gonadotropin with 2 subunits, alpha = 92 residues, beta = 145 residues, each with N-and O-linked carbohydrate moieties linked to ASN-52 and ASN-78 (on alpha subunit) and ASN-13, ASN-30, SER-121, SER-127, SER-132 and SER-138 (on beta subunit). The primary structure of the alpha-chain of r-hCG is identical to that of the alpha-chain of hCG, FSH and LH. |
Structure |
|
Categories (*) | |
Molecular Weight | 25719.7000 |
Groups | approved |
Monoisotopic Weight | Not Available |
Pharmacology | |
Indication | For the treatment of female infertility |
Mechanism of action | Choriogonadotropin alfa binds to the Follicle stimulating hormone receptor which results in ovulation in the absence of sufficient endogenous Luteinizing hormone. |
Absorption | The mean absolute bioavailability following a single subcutaneous injection to healthy female volunteers is about 40%. |
Protein binding | Not Available |
Biotransformation | Not Available |
Route of elimination | One-tenth of the dose is excreted in the urine. |
Toxicity | Not Available |
Affected organisms |
|
Interactions | |
Drug Interactions | Not Available |
Food Interactions | Not Available |
Lutropin-choriogonadotropic hormone receptor | |
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Name | Lutropin-choriogonadotropic hormone receptor |
Gene Name | LHCGR |
Pharmacological action | yes |
Actions | Not Available |
References |
|
DTHybrid score | 1.4276 |
Follicle-stimulating hormone receptor | |
Name | Follicle-stimulating hormone receptor |
Gene Name | FSHR |
Pharmacological action | yes |
Actions | binder |
References |
|
DTHybrid score | 1.5369 |
Id | Partner name | Gene Name | Score |
---|---|---|---|
226 | Gonadotropin-releasing hormone receptor | GNRHR | 0.3353 |
3811 | Cytochrome P450 19A1 | CYP19A1 | 0.0561 |
4165 | P2Y purinoceptor 2 | P2RY2 | 0.0522 |
2654 | Complement control protein | C3L | 0.0419 |
814 | Ryanodine receptor 1 | RYR1 | 0.0397 |
5455 | Arylsulfatase A | ARSA | 0.0388 |
5766 | NAD-dependent deacetylase sirtuin-5 | SIRT5 | 0.0378 |
2981 | Phospholipase A2, membrane associated | PLA2G2A | 0.0305 |
723 | Cytosolic phospholipase A2 | PLA2G4A | 0.0303 |
54 | Prothrombin | F2 | 0.0207 |