DT-Web

DB00097 - Choriogonadotropin alfa


Identification
Name Choriogonadotropin alfa
Accession Number DB00097 (BIOD00034, BTD00034)
Type biotech
Description Recombinant human chorionic gonadotropin with 2 subunits, alpha = 92 residues, beta = 145 residues, each with N-and O-linked carbohydrate moieties linked to ASN-52 and ASN-78 (on alpha subunit) and ASN-13, ASN-30, SER-121, SER-127, SER-132 and SER-138 (on beta subunit). The primary structure of the alpha-chain of r-hCG is identical to that of the alpha-chain of hCG, FSH and LH.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 25719.7000
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication For the treatment of female infertility
Mechanism of action Choriogonadotropin alfa binds to the Follicle stimulating hormone receptor which results in ovulation in the absence of sufficient endogenous Luteinizing hormone.
Absorption The mean absolute bioavailability following a single subcutaneous injection to healthy female volunteers is about 40%.
Protein binding Not Available
Biotransformation Not Available
Route of elimination One-tenth of the dose is excreted in the urine.
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Lutropin-choriogonadotropic hormone receptor
Name Lutropin-choriogonadotropic hormone receptor
Gene Name LHCGR
Pharmacological action yes
Actions Not Available
References
  • Bodek G, Vierre S, Rivero-Muller A, Huhtaniemi I, Ziecik AJ, Rahman NA: A novel targeted therapy of Leydig and granulosa cell tumors through the luteinizing hormone receptor using a hecate-chorionic gonadotropin beta conjugate in transgenic mice. Neoplasia. 2005 May;7(5):497-508. - Pubmed
  • Gromoll J, Wistuba J, Terwort N, Godmann M, Muller T, Simoni M: A new subclass of the luteinizing hormone/chorionic gonadotropin receptor lacking exon 10 messenger RNA in the New World monkey (Platyrrhini) lineage. Biol Reprod. 2003 Jul;69(1):75-80. Epub 2003 Feb 19. - Pubmed
  • Lin W, Bernard MP, Cao D, Myers RV, Kerrigan JE, Moyle WR: Follitropin receptors contain cryptic ligand binding sites. Mol Cell Endocrinol. 2007 Jan 2;260-262:83-92. Epub 2006 Oct 23. - Pubmed
DTHybrid score 1.4276
Follicle-stimulating hormone receptor
Name Follicle-stimulating hormone receptor
Gene Name FSHR
Pharmacological action yes
Actions binder
References
  • Jameson JL: Inherited disorders of the gonadotropin hormones. Mol Cell Endocrinol. 1996 Dec 20;125(1-2):143-9. - Pubmed
  • Lin W, Bernard MP, Cao D, Myers RV, Kerrigan JE, Moyle WR: Follitropin receptors contain cryptic ligand binding sites. Mol Cell Endocrinol. 2007 Jan 2;260-262:83-92. Epub 2006 Oct 23. - Pubmed
  • Tao YX, Segaloff DL: Chapter 5 Follicle Stimulating Hormone Receptor Mutations and Reproductive Disorders. Prog Mol Biol Transl Sci. 2009;89C:115-131. Epub 2009 Oct 7. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.5369

Predictions


Id Partner name Gene Name Score
226 Gonadotropin-releasing hormone receptor GNRHR 0.3353
3811 Cytochrome P450 19A1 CYP19A1 0.0561
4165 P2Y purinoceptor 2 P2RY2 0.0522
2654 Complement control protein C3L 0.0419
814 Ryanodine receptor 1 RYR1 0.0397
5455 Arylsulfatase A ARSA 0.0388
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0378
2981 Phospholipase A2, membrane associated PLA2G2A 0.0305
723 Cytosolic phospholipase A2 PLA2G4A 0.0303
54 Prothrombin F2 0.0207
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