Identification | |
---|---|
Name | Felypressin |
Accession Number | DB00093 (BIOD00114, BTD00114) |
Type | biotech |
Description | Synthetic analog of lypressin with more vasoconstrictor than antidiuretic action. It is used as a hemostatic. |
Structure |
|
Categories (*) | |
Molecular Weight | 1040.2190 |
Groups | approved |
Monoisotopic Weight | Not Available |
Pharmacology | |
Indication | For use as an alternative to adrenaline as a localising agent, provided that local ischaemia is not essential. |
Mechanism of action | Felypressin binds to the vasopressin receptor V1a. This causes contraction of the smooth muscle in the vascular bed, especially capillaries, small arterioles and venules. |
Absorption | Not Available |
Protein binding | Not Available |
Biotransformation | Not Available |
Route of elimination | Not Available |
Toxicity | Not Available |
Affected organisms |
|
Interactions | |
Drug Interactions | Not Available |
Food Interactions | Not Available |
Vasopressin V1a receptor | |
---|---|
Name | Vasopressin V1a receptor |
Gene Name | AVPR1A |
Pharmacological action | yes |
Actions | agonist |
References |
|
DTHybrid score | 0.7353 |
Id | Partner name | Gene Name | Score |
---|---|---|---|
322 | Vasopressin V2 receptor | AVPR2 | 0.366 |
850 | Vasopressin V1b receptor | AVPR1B | 0.2393 |
4512 | Cytochrome P450 3A4 | CYP3A4 | 0.052 |
1735 | Canalicular multispecific organic anion transporter 1 | ABCC2 | 0.0327 |
290 | Prostaglandin G/H synthase 2 | PTGS2 | 0.0271 |
20 | Prostaglandin G/H synthase 1 | PTGS1 | 0.0254 |
1588 | Multidrug resistance protein 1 | ABCB1 | 0.0253 |