DT-Web

DB00064 - Serum albumin iodonated


Identification
Name Serum albumin iodonated
Accession Number DB00064 (BIOD00089, BTD00089)
Type biotech
Description A diagnostic radiopharmaceutical containing iodinated I 131 albumin for intravenous imaging. Following intravenous injection, radioiodinated albumin human is uniformly distributed throughout the intravascular pool within 10 minutes; extravascular distribution takes place more slowly (2 days). Indicated for use in determinations of total blood and plasma volumes, cardiac output, cardiac and pulmonary blood volumes and circulation times
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 66472.2000
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication For determination of total blood and plasma volumes
Mechanism of action Serum albumin acts as a high molecular weight, very soluble osmolyte
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Apolipoprotein E
Name Apolipoprotein E
Gene Name APOE
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Wang L, Li CM, Rudolf M, Curcio CA, Peng D, Liu X, Zeng S: [Gene expression of apolipoprotein and lipids synthesis and secretion in RPE-J cells] Yan Ke Xue Bao. 2006 Dec;22(4):244-51. - Pubmed
  • Cano NJ, Saingra Y, Dupuy AM, Lorec-Penet AM, Portugal H, Lairon D, Cristol JP, Come A, Le Brun A, Atlan P, Leverve XM: Intradialytic parenteral nutrition: comparison of olive oil versus soybean oil-based lipid emulsions. Br J Nutr. 2006 Jan;95(1):152-9. - Pubmed
DTHybrid score 1.3523
Serum amyloid A protein
Name Serum amyloid A protein
Gene Name SAA1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Danesh J, Muir J, Wong YK, Ward M, Gallimore JR, Pepys MB: Risk factors for coronary heart disease and acute-phase proteins. A population-based study. Eur Heart J. 1999 Jul;20(13):954-9. - Pubmed
  • Danesh J, Whincup P, Walker M, Lennon L, Thomson A, Appleby P, Gallimore JR, Pepys MB: Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses. BMJ. 2000 Jul 22;321(7255):199-204. - Pubmed
  • Grehan S, Uhlar CM, Sim RB, Herbert J, Whitehead AS: Expression of a biologically active recombinant mouse IL-1 receptor antagonist and its use in vivo to modulate aspects of the acute phase response. J Immunol. 1997 Jul 1;159(1):369-78. - Pubmed
DTHybrid score 1.3528
AMBP protein
Name AMBP protein
Gene Name AMBP
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.3523

Predictions


Id Partner name Gene Name Score
1757 Myeloperoxidase MPO 0.2636
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.2477
4757 Cytochrome P450 2C9 CYP2C9 0.1591
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