Identification | |
---|---|
Name | OspA lipoprotein |
Accession Number | DB00045 (BIOD00054, BTD00054) |
Type | biotech |
Description | Vaccine against Lyme disease that contains lipoprotein OspA, an outer surface protein of Borrelia burgdorferi sensu stricto ZS7, as expressed by Escherichia coli. Lipoprotein OspA is a single polypeptide chain of 257 amino acids with lipids covalently bonded to the N terminus. It is conjugated with alum (aluminum hydroxide) as an adjuvant. |
Structure |
|
Categories (*) | |
Molecular Weight | 27743.1000 |
Groups | approved |
Monoisotopic Weight | Not Available |
Pharmacology | |
Indication | For prophylactic treatment of Lyme Disease |
Mechanism of action | OspA lipoprotein, an outer surface protein of the bacteria Borrelia burgdorferi sensu stricto ZS7, is used to stimulate the production of specific antibodies against B. burgdorferi. It is used as a vaccination against Lyme Disease, a disease carried by ticks. |
Absorption | Not Available |
Protein binding | Not Available |
Biotransformation | Not Available |
Route of elimination | Not Available |
Toxicity | Not Available |
Affected organisms |
|
Interactions | |
Drug Interactions | Not Available |
Food Interactions | Not Available |
Toll-like receptor 2 | |
---|---|
Name | Toll-like receptor 2 |
Gene Name | TLR2 |
Pharmacological action | yes |
Actions | other/unknown |
References |
|
DTHybrid score | 1.125 |
Id | Partner name | Gene Name | Score |
---|---|---|---|
2939 | Peptide methionine sulfoxide reductase msrA | msrA | 0.1223 |
2888 | DNA-repair protein XRCC4 | XRCC4 | 0.1222 |
2906 | Coatomer subunit gamma | COPG | 0.1222 |
2433 | Capsid protein P40 | UL80 | 0.0981 |
3569 | Capsid protein P40 | BVRF2 | 0.0981 |
2297 | Genome polyprotein | Not Available | 0.0828 |
2322 | Genome polyprotein | Not Available | 0.0828 |
2694 | Genome polyprotein | Not Available | 0.0828 |
2719 | Genome polyprotein | Not Available | 0.0828 |
2860 | Genome polyprotein | Not Available | 0.0828 |
2928 | Genome polyprotein | Not Available | 0.0828 |
3160 | Genome polyprotein | Not Available | 0.0828 |
3260 | Genome polyprotein | Not Available | 0.0828 |
4783 | Genome polyprotein | Not Available | 0.0828 |
5726 | Genome polyprotein | Not Available | 0.0828 |
5779 | Genome polyprotein | Not Available | 0.0828 |
5867 | Genome polyprotein | Not Available | 0.0828 |
6253 | Genome polyprotein | Not Available | 0.0828 |
6301 | Genome polyprotein | Not Available | 0.0828 |
6380 | Genome polyprotein | Not Available | 0.0828 |
6381 | Genome polyprotein | Not Available | 0.0828 |
6437 | Genome polyprotein | Not Available | 0.0828 |
6520 | Genome polyprotein | Not Available | 0.0828 |
6521 | Genome polyprotein | Not Available | 0.0828 |
6652 | Genome polyprotein | Not Available | 0.0828 |
6734 | Genome polyprotein | Not Available | 0.0828 |
6735 | Genome polyprotein | Not Available | 0.0828 |
6736 | Genome polyprotein | Not Available | 0.0828 |
6737 | Genome polyprotein | Not Available | 0.0828 |
6738 | Genome polyprotein | Not Available | 0.0828 |
6739 | Genome polyprotein | Not Available | 0.0828 |
6744 | Genome polyprotein | Not Available | 0.0828 |
6748 | Genome polyprotein | Not Available | 0.0828 |
6894 | Genome polyprotein | Not Available | 0.0828 |
6898 | Genome polyprotein | Not Available | 0.0828 |
864 | Gag-Pol polyprotein | gag-pol | 0.0787 |
2237 | Gag-Pol polyprotein | gag-pol | 0.0787 |
2326 | Gag-Pol polyprotein | gag-pol | 0.0787 |
2451 | Gag-Pol polyprotein | gag-pol | 0.0787 |
2901 | Gag-Pol polyprotein | gag-pol | 0.0787 |
3165 | Gag-Pol polyprotein | gag-pol | 0.0787 |
3722 | Gag-Pol polyprotein | gag-pol | 0.0787 |
6306 | Gag-Pol polyprotein | gag-pol | 0.0787 |
6624 | Gag-Pol polyprotein | gag-pol | 0.0787 |
291 | Nitric-oxide synthase, endothelial | NOS3 | 0.0566 |