Identification | |
---|---|
Name | Lutropin alfa |
Accession Number | DB00044 (BIOD00056, BTD00056) |
Type | biotech |
Description | Recombinant human luteinizing hormone produced in yeast with 2 subunits, alpha = 92 residues, beta = 121 residues |
Structure |
|
Categories (*) | |
Molecular Weight | 23390.3000 |
Groups | approved |
Monoisotopic Weight | Not Available |
Pharmacology | |
Indication | For treatment of female infertility |
Mechanism of action | Binds to the luteinizing hormone receptor which then activates adenylate cylcase through G protein mediation. Adenylate cyclase then activates many other pathways leading to steroid hormone production and other follicle maturation processes. |
Absorption | Not Available |
Protein binding | Not Available |
Biotransformation | Not Available |
Route of elimination | Total body clearance is approximately 2 to 3 L/h with less than 5 percent of the dose being excreted unchanged renally. |
Toxicity | Not Available |
Affected organisms |
|
Interactions | |
Drug Interactions | Not Available |
Food Interactions | Not Available |
Lutropin-choriogonadotropic hormone receptor | |
---|---|
Name | Lutropin-choriogonadotropic hormone receptor |
Gene Name | LHCGR |
Pharmacological action | yes |
Actions | agonist |
References |
|
DTHybrid score | 1.1013 |
Id | Partner name | Gene Name | Score |
---|---|---|---|
226 | Gonadotropin-releasing hormone receptor | GNRHR | 0.3353 |
430 | Follicle-stimulating hormone receptor | FSHR | 0.2925 |
3811 | Cytochrome P450 19A1 | CYP19A1 | 0.0561 |