DT-Web

DB00036 - Coagulation factor VIIa


Identification
Name Coagulation factor VIIa
Accession Number DB00036 (BIOD00006, BTD00006)
Type biotech
Description Recombinant human coagulation Factor VIIa (rFVIIa), intended for promoting hemostasis by activating the extrinsic pathway of the coagulation cascade.1 NovoSeven is a vitamin K-dependent glycoprotein consisting of 406 amino acid residues. Cloned and expressed in hamster kidney cells, the protein is catalytically active in a two-chain form.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 45079.1000
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication For treatment of hemorrhagic complications in hemophilia A and B
Mechanism of action NovoSeven activates the coagulation or clotting cascade by cleaving Factor IX and Factor X, which activates them and then leads to activation of thrombin and fibrin.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Coagulation factor X
Name Coagulation factor X
Gene Name F10
Pharmacological action unknown
Actions Not Available
References
  • Malinvaud G: [Reflections on the use of PPSB fraction (Prothrombin-proconvertin-Stuart factor-antihemophilic factor B)] Transfusion (Paris). 1966;9(3):245-54. - Pubmed
  • BLATRIX C, SOULIER JP: [Preparation of a fraction rich in prothrombin, proconvertin, Stuart factor and antihemophilic factor B (P.P.B. fraction)] Pathol Biol (Paris). 1959 Dec;7:2477-86. - Pubmed
  • HERMANSKY F, VITEK J: The role of proconvertin and Stuart factor in the inactivation of tissue thromboplastin by serum. Experientia. 1960 Oct 15;16:455-6. - Pubmed
  • GAERTNER H, CAEN J: [FUNCTIONAL RELATION BETWEEN ERYTHROPLASTIN (ERYTHROCYTE COAGULANT FACTOR) AND PLASMA FACTORS: PROACCELERIN (V), PROCONVERTIN (VII) AND STUART FACTOR(X).] Acta Physiol Pol. 1964 Mar-Apr;15:237-43. - Pubmed
  • DIDISHEIM P, LOEB J, BLATRIX C, SOULIER JP: Preparation of a human plasma fraction rich in prothrombin, proconvertin, Stuart factor, and PTC and a study of its activity and toxicity in rabbits and man. J Lab Clin Med. 1959 Feb;53(2):322-30. - Pubmed
DTHybrid score 1.6731
Serine protease hepsin
Name Serine protease hepsin
Gene Name HPN
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0273
Tissue factor pathway inhibitor
Name Tissue factor pathway inhibitor
Gene Name TFPI
Pharmacological action unknown
Actions Not Available
References
  • Mine S, Yamazaki T, Miyata T, Hara S, Kato H: Structural mechanism for heparin-binding of the third Kunitz domain of human tissue factor pathway inhibitor. Biochemistry. 2002 Jan 8;41(1):78-85. - Pubmed
  • Narita M, Bu G, Olins GM, Higuchi DA, Herz J, Broze GJ Jr, Schwartz AL: Two receptor systems are involved in the plasma clearance of tissue factor pathway inhibitor in vivo. J Biol Chem. 1995 Oct 20;270(42):24800-4. - Pubmed
  • Stassens P, Bergum PW, Gansemans Y, Jespers L, Laroche Y, Huang S, Maki S, Messens J, Lauwereys M, Cappello M, Hotez PJ, Lasters I, Vlasuk GP: Anticoagulant repertoire of the hookworm Ancylostoma caninum. Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2149-54. - Pubmed
  • Lee AY, Vlasuk GP: Recombinant nematode anticoagulant protein c2 and other inhibitors targeting blood coagulation factor VIIa/tissue factor. J Intern Med. 2003 Oct;254(4):313-21. - Pubmed
  • Hansen CB, Pyke C, Petersen LC, Rao LV: Tissue factor-mediated endocytosis, recycling, and degradation of factor VIIa by a clathrin-independent mechanism not requiring the cytoplasmic domain of tissue factor. Blood. 2001 Mar 15;97(6):1712-20. - Pubmed
DTHybrid score 0.6155
Vitamin K-dependent gamma-carboxylase
Name Vitamin K-dependent gamma-carboxylase
Gene Name GGCX
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Bouwman CA, Van Dam E, Fase KM, Koppe JG, Seinen W, Thijssen HH, Vermeer C, Van den Berg M: Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin or 2,2',4,4',5,5'-hexachlorobiphenyl on vitamin K-dependent blood coagulation in male and female WAG/Rij-rats. Chemosphere. 1999 Feb;38(3):489-505. - Pubmed
DTHybrid score 0.7927
Coagulation factor VII
Name Coagulation factor VII
Gene Name F7
Pharmacological action unknown
Actions Not Available
References
  • Perera L, Darden TA, Pedersen LG: Probing the structural changes in the light chain of human coagulation factor VIIa due to tissue factor association. Biophys J. 1999 Jul;77(1):99-113. - Pubmed
  • Shapiro A: Inhibitor treatment: state of the art. Semin Hematol. 2001 Oct;38(4 Suppl 12):26-34. - Pubmed
  • Shapiro A: Inhibitor treatment: state of the art. Dis Mon. 2003 Jan;49(1):22-38. - Pubmed
  • Siddiqui MA, Scott LJ: Recombinant factor VIIa (Eptacog Alfa): a review of its use in congenital or acquired haemophilia and other congenital bleeding disorders. Drugs. 2005;65(8):1161-77. - Pubmed
  • Rizoli SB, Chughtai T: The emerging role of recombinant activated Factor VII (rFVIIa) in the treatment of blunt traumatic haemorrhage. Expert Opin Biol Ther. 2006 Jan;6(1):73-81. - Pubmed
DTHybrid score 1.9643
Tissue factor
Name Tissue factor
Gene Name F3
Pharmacological action unknown
Actions Not Available
References
  • HERMANSKY F, VITEK J: The role of proconvertin and Stuart factor in the inactivation of tissue thromboplastin by serum. Experientia. 1960 Oct 15;16:455-6. - Pubmed
  • Rogers KS, Barton CL, Benson PA, Green RA: Effects of single-dose L-asparaginase on coagulation values in healthy dogs and dogs with lymphoma. Am J Vet Res. 1992 Apr;53(4):580-4. - Pubmed
  • Christensen NJ: Measurements of some blood clotting factors using a centrifugal analyser (Multistat III). Scand J Clin Lab Invest. 1983 Oct;43(6):521-6. - Pubmed
DTHybrid score 1.3503

Predictions


Id Partner name Gene Name Score
54 Prothrombin F2 0.2067
1719 Heparanase HPSE 0.1867
309 Antithrombin-III SERPINC1 0.1768
2058 P-selectin SELP 0.1638
798 Osteocalcin BGLAP 0.1481
3176 Trypsin-1 PRSS1 0.1305
183 Vascular endothelial growth factor A VEGFA 0.1237
19 Coagulation factor VIII F8 0.1109
3831 Low-density lipoprotein receptor-related protein 1 LRP1 0.0838
5212 Carboxylesterase 2 estB 0.073
5211 Extracellular subtilisin-like serine proteinase Not Available 0.0729
3490 Sigma factor sigB regulation protein rsbQ rsbQ 0.0581
1547 Coagulation factor XI F11 0.0559
1074 Urokinase-type plasminogen activator PLAU 0.0541
1615 Chymase CMA1 0.0528
2517 Subtilisin BPN' apr 0.0524
1245 Vitamin K-dependent protein S PROS1 0.0442
400 Coagulation factor IX F9 0.0319
5461 Coagulation factor IX F9 0.0319
1959 Platelet factor 4 PF4 0.0299
3865 Serpin B6 SERPINB6 0.0299
1986 Ceruloplasmin CP 0.0299
422 Vitamin K-dependent protein C PROC 0.0273
604 Vitamin K-dependent protein Z PROZ 0.0272
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0272
3833 Plasma serine protease inhibitor SERPINA5 0.026
46 Coagulation factor V F5 0.0236
2021 Thrombomodulin THBD 0.0235
2072 Endothelial protein C receptor PROCR 0.023
267 Plasminogen activator inhibitor 1 SERPINE1 0.0196
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0182
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0172
3917 Methylenetetrahydrofolate reductase MTHFR 0.0164
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.016
6020 Aldehyde oxidase AOX1 0.0153
6182 Cytochrome P450 2J2 CYP2J2 0.0145
3947 Xanthine dehydrogenase/oxidase XDH 0.014
1757 Myeloperoxidase MPO 0.0118
5718 Cytochrome P450 2A6 CYP2A6 0.011
4200 Cytochrome P450 1A2 CYP1A2 0.0108
6024 Cytochrome P450 1A1 CYP1A1 0.0104
6013 Cytochrome P450 2E1 CYP2E1 0.0099
3842 Multiple coagulation factor deficiency protein 2 MCFD2 0.007
3841 ERGIC-53 protein LMAN1 0.007
3840 Asialoglycoprotein receptor 2 ASGR2 0.007
1847 78 kDa glucose-regulated protein HSPA5 0.007
1635 von Willebrand factor VWF 0.007
4118 Cytochrome P450 3A5 CYP3A5 0.0067
1588 Multidrug resistance protein 1 ABCB1 0.0063
1516 Calnexin CANX 0.0061
4512 Cytochrome P450 3A4 CYP3A4 0.0055
3830 Calreticulin CALR 0.005
3839 Phytanoyl-CoA dioxygenase, peroxisomal PHYH 0.0049
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0042
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0042
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0042
4019 Excitatory amino acid transporter 4 SLC1A6 0.0042
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0042
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0042
4026 Aspartyl aminopeptidase DNPEP 0.0042
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0042
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0042
1912 Excitatory amino acid transporter 1 SLC1A3 0.0042
4016 Excitatory amino acid transporter 5 SLC1A7 0.0042
1047 Excitatory amino acid transporter 2 SLC1A2 0.0042
922 Glutamate receptor 4 GRIA4 0.0042
664 Glutamate decarboxylase 2 GAD2 0.0042
3890 Glutamate decarboxylase 2 GAD2 0.0042
926 Metabotropic glutamate receptor 7 GRM7 0.0042
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0042
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0042
927 Metabotropic glutamate receptor 8 GRM8 0.0042
925 Metabotropic glutamate receptor 4 GRM4 0.0042
4020 Glutamyl aminopeptidase ENPEP 0.0042
4018 Glutamate receptor delta-2 subunit GRID2 0.0042
4027 Glutamate receptor delta-1 subunit GRID1 0.0042
4017 5-oxoprolinase OPLAH 0.0042
917 Glutaminase kidney isoform, mitochondrial GLS 0.0036
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0036
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0036
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0036
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0036
5 Glutaminase liver isoform, mitochondrial GLS2 0.0036
665 Phosphoserine aminotransferase PSAT1 0.0036
4652 Phosphoserine aminotransferase serC 0.0036
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0036
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0036
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0036
5261 Phosphoribosylformylglycinamidine synthase purL 0.0036
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0036
420 Glutamate decarboxylase 1 GAD1 0.0036
3900 Glutamate decarboxylase 1 GAD1 0.0036
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0035
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0035
625 Glutamate carboxypeptidase 2 FOLH1 0.0033
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0033
916 Metabotropic glutamate receptor 1 GRM1 0.0033
3877 Growth-inhibiting protein 18 GIG18 0.0033
1671 Excitatory amino acid transporter 3 SLC1A1 0.0033
923 Glutamate receptor 3 GRIA3 0.0032
763 Tyrosine aminotransferase TAT 0.0031
5493 Tyrosine aminotransferase Not Available 0.0031
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0031
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0031
735 Alanine aminotransferase 1 GPT 0.0031
3904 Alanine aminotransferase 2 GPT2 0.0031
426 Aspartate aminotransferase, mitochondrial GOT2 0.0031
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0031
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.003
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.003
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.003
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0029
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0029
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0029
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0029
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0028
705 Glutamate receptor 1 GRIA1 0.0028
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0027
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0027
33 Cystine/glutamate transporter SLC7A11 0.0027
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0027
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0027
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0027
3426 Glutamine synthetase glnA 0.0027
3987 Glutamine synthetase GLUL 0.0027
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0026
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0022
4924 Cytochrome P450 2C8 CYP2C8 0.0022
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0022
738 Monocarboxylate transporter 1 SLC16A1 0.0021
6016 Cytochrome P450 2C19 CYP2C19 0.0021
4757 Cytochrome P450 2C9 CYP2C9 0.002
6151 Monocarboxylate transporter 10 SLC16A10 0.002
921 Glutamate receptor 2 GRIA2 0.0019
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