Identification | |
---|---|
Name | Menotropins |
Accession Number | DB00032 (BIOD00018, BTD00018) |
Type | biotech |
Description | Mixture of luteinizing hormone and follicle stimulating hormone extracted from the urine of postmeonopausal women. Composed of LH with 2 subunits, alpha = 92 residues, beta = 121 residues and FSH with 2 subunits, alpha = 92 residues, beta=111 residues |
Structure |
|
Categories (*) | |
Molecular Weight | 23390.3000 |
Groups | approved |
Monoisotopic Weight | Not Available |
Pharmacology | |
Indication | For the treatment of female infertility |
Mechanism of action | Being a combination drug, Menotropins bind to the Follicle stimulating hormone receptor (which results in ovulation in the absence of sufficient endogenous Luteinizing hormone)and It also binds to the LH receptor, thereby stimulating proper hormone release. The drug contains both FSH and LH,therefore, it induces ovarian follicular growth and development as well as gonadal steroid production in women who do not have ovarian failure.FSH is the primary driver of follicular recruitment and growth in early folliculogenesis, while LH is important for ovarian steroidogenesis and is involved in the physiological events leading to development of a competent pre-ovulatory follicle |
Absorption | Not Available |
Protein binding | Not Available |
Biotransformation | Not Available |
Route of elimination | Not Available |
Toxicity | Not Available |
Affected organisms |
|
Interactions | |
Drug Interactions | Not Available |
Food Interactions | Not Available |
Follicle-stimulating hormone receptor | |
---|---|
Name | Follicle-stimulating hormone receptor |
Gene Name | FSHR |
Pharmacological action | yes |
Actions | binder |
References |
|
DTHybrid score | 1.5369 |
Lutropin-choriogonadotropic hormone receptor | |
Name | Lutropin-choriogonadotropic hormone receptor |
Gene Name | LHCGR |
Pharmacological action | yes |
Actions | Not Available |
References |
|
DTHybrid score | 1.4276 |
Id | Partner name | Gene Name | Score |
---|---|---|---|
226 | Gonadotropin-releasing hormone receptor | GNRHR | 0.3353 |
3811 | Cytochrome P450 19A1 | CYP19A1 | 0.0561 |
4165 | P2Y purinoceptor 2 | P2RY2 | 0.0522 |
2654 | Complement control protein | C3L | 0.0419 |
814 | Ryanodine receptor 1 | RYR1 | 0.0397 |
5455 | Arylsulfatase A | ARSA | 0.0388 |
5766 | NAD-dependent deacetylase sirtuin-5 | SIRT5 | 0.0378 |
2981 | Phospholipase A2, membrane associated | PLA2G2A | 0.0305 |
723 | Cytosolic phospholipase A2 | PLA2G4A | 0.0303 |
54 | Prothrombin | F2 | 0.0207 |