Identification | |
---|---|
Name | Antihemophilic Factor |
Accession Number | DB00025 (BIOD00029, BTD00029) |
Type | biotech |
Description | Human recombinant antihemophilic factor (AHF) or Factor VIII, 2332 residues, glycosylated, produced by CHO cells |
Structure |
|
Categories (*) | |
Molecular Weight | 264725.5000 |
Groups | approved |
Monoisotopic Weight | Not Available |
Pharmacology | |
Indication | For the treatment of hemophilia A, von Willebrand disease and Factor XIII deficiency. |
Mechanism of action | Antihemophilic factor (AHF) is a protein found in normal plasma which is necessary for clot formation. The administration of AHF provides an increase in plasma levels of AHF and can temporarily correct the coagulation defect of patients with hemophilia A (classical hemophilia). |
Absorption | Not Available |
Protein binding | Not Available |
Biotransformation | Not Available |
Route of elimination | Not Available |
Toxicity | Not Available |
Affected organisms |
|
Interactions | |
Drug Interactions | Not Available |
Food Interactions | Not Available |
Coagulation factor X | |
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Name | Coagulation factor X |
Gene Name | F10 |
Pharmacological action | yes |
Actions | activator |
References |
|
DTHybrid score | 2.0297 |
Coagulation factor IX | |
Name | Coagulation factor IX |
Gene Name | F9 |
Pharmacological action | yes |
Actions | cofactor |
References |
|
DTHybrid score | 0.9985 |
von Willebrand factor | |
Name | von Willebrand factor |
Gene Name | VWF |
Pharmacological action | yes |
Actions | binder |
References |
|
DTHybrid score | 1.076 |
Phytanoyl-CoA dioxygenase, peroxisomal | |
Name | Phytanoyl-CoA dioxygenase, peroxisomal |
Gene Name | PHYH |
Pharmacological action | unknown |
Actions | antagonist |
References |
|
DTHybrid score | 0.9509 |
Asialoglycoprotein receptor 2 | |
Name | Asialoglycoprotein receptor 2 |
Gene Name | ASGR2 |
Pharmacological action | unknown |
Actions | binder |
References |
|
DTHybrid score | 1.0768 |
78 kDa glucose-regulated protein | |
Name | 78 kDa glucose-regulated protein |
Gene Name | HSPA5 |
Pharmacological action | unknown |
Actions | chaperone |
References |
|
DTHybrid score | 1.0767 |
Calreticulin | |
Name | Calreticulin |
Gene Name | CALR |
Pharmacological action | unknown |
Actions | chaperone |
References |
|
DTHybrid score | 1.063 |
Calnexin | |
Name | Calnexin |
Gene Name | CANX |
Pharmacological action | unknown |
Actions | chaperone |
References |
|
DTHybrid score | 1.1319 |
ERGIC-53 protein | |
Name | ERGIC-53 protein |
Gene Name | LMAN1 |
Pharmacological action | unknown |
Actions | chaperone |
References |
|
DTHybrid score | 1.0766 |
Low-density lipoprotein receptor-related protein 1 | |
Name | Low-density lipoprotein receptor-related protein 1 |
Gene Name | LRP1 |
Pharmacological action | unknown |
Actions | modulator |
References |
|
DTHybrid score | 1.1468 |
Multiple coagulation factor deficiency protein 2 | |
Name | Multiple coagulation factor deficiency protein 2 |
Gene Name | MCFD2 |
Pharmacological action | unknown |
Actions | modulator |
References | |
DTHybrid score | 1.0774 |
Prothrombin | |
---|---|
Name | Prothrombin |
Gene Name | F2 |
Actions | activator |
References |
|
DTHybrid score | 2.1003 |
Vitamin K-dependent protein C | |
Name | Vitamin K-dependent protein C |
Gene Name | PROC |
Actions | inactivator |
References |
|
DTHybrid score | 1.2108 |