DT-Web

DB00020 - Sargramostim


Identification
Name Sargramostim
Accession Number DB00020 (BIOD00035, BTD00035)
Type biotech
Description Human, recombinant GM-CSF, expressed in yeast. Glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 14434.5000
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication For the treatment of cancer and bone marrow transplant
Mechanism of action Sargramostim binds to the Granulocyte-macrophage colony stimulating factor receptor (GM-CSF-R-alpha or CSF2R) which stimulates a JAK2 STAT1/STAT3 signal transduction pathway. This leads to the production of hemopoietic cells and neutrophils
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Granulocyte-macrophage colony-stimulating factor receptor alpha chain
Name Granulocyte-macrophage colony-stimulating factor receptor alpha chain
Gene Name CSF2RA
Pharmacological action yes
Actions agonist
References
  • Wang Y, Cai D, Brendel C, Barett C, Erben P, Manley PW, Hochhaus A, Neubauer A, Burchert A: Adaptive secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) mediates imatinib and nilotinib resistance in BCR/ABL+ progenitors via JAK-2/STAT-5 pathway activation. Blood. 2007 Mar 1;109(5):2147-55. Epub 2006 Nov 7. - Pubmed
  • Chen J, Carcamo JM, Golde DW: The alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor interacts with c-Kit and inhibits c-Kit signaling. J Biol Chem. 2006 Aug 4;281(31):22421-6. Epub 2006 Jun 7. - Pubmed
  • Lencz T, Morgan TV, Athanasiou M, Dain B, Reed CR, Kane JM, Kucherlapati R, Malhotra AK: Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia. Mol Psychiatry. 2007 Jun;12(6):572-80. Epub 2007 Mar 20. - Pubmed
  • Xiao R, Zhang R, Wang YL, Zhu ZL, Chen T, Yang JH: [Expression of soluble GM-CSF-Ralpha in patients with acute myeloid leukemia] Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2006 Apr;14(2):225-7. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.6181
Interleukin-3 receptor alpha chain
Name Interleukin-3 receptor alpha chain
Gene Name IL3RA
Pharmacological action yes
Actions agonist
References
  • Eksioglu EA, Mahmood SS, Chang M, Reddy V: GM-CSF promotes differentiation of human dendritic cells and T lymphocytes toward a predominantly type 1 proinflammatory response. Exp Hematol. 2007 Aug;35(8):1163-71. Epub 2007 Jun 11. - Pubmed
  • Sakhno LV, Leplina OIu, Tikhonova MA, Raspai ZhM, Gileva IP, Nikonov SD, Zhdanov OA, Ostanin AA, Chernykh ER: [Characteristics of A-interferon-generated dendritic cells in patients with pulmonary tuberculosis] Probl Tuberk Bolezn Legk. 2007;(3):42-6. - Pubmed
  • Ward KA, Stewart LA, Schwarer AP: CD34+-derived CD11c+ + + BDCA-1+ + CD123+ + DC: expansion of a phenotypically undescribed myeloid DC1 population for use in adoptive immunotherapy. Cytotherapy. 2006;8(2):130-40. - Pubmed
  • Lencz T, Morgan TV, Athanasiou M, Dain B, Reed CR, Kane JM, Kucherlapati R, Malhotra AK: Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia. Mol Psychiatry. 2007 Jun;12(6):572-80. Epub 2007 Mar 20. - Pubmed
DTHybrid score 1.618
Cytokine receptor common beta chain
Name Cytokine receptor common beta chain
Gene Name CSF2RB
Pharmacological action yes
Actions agonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Shen Y, Baker E, Callen DF, Sutherland GR, Willson TA, Rakar S, Gough NM: Localization of the human GM-CSF receptor beta chain gene (CSF2RB) to chromosome 22q12.2-->q13.1. Cytogenet Cell Genet. 1992;61(3):175-7. - Pubmed
DTHybrid score 1.4009
Syndecan-2
Name Syndecan-2
Gene Name SDC2
Pharmacological action unknown
Actions agonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Modrowski D, Basle M, Lomri A, Marie PJ: Syndecan-2 is involved in the mitogenic activity and signaling of granulocyte-macrophage colony-stimulating factor in osteoblasts. J Biol Chem. 2000 Mar 31;275(13):9178-85. - Pubmed
DTHybrid score 1.6182
Bone-marrow proteoglycan
Name Bone-marrow proteoglycan
Gene Name PRG2
Pharmacological action unknown
Actions Not Available
References
  • Menon K, Wu Y, Haas J, Sahu SK, Yang B, Zaheer A: Diminished degradation of myelin basic protein by anti-sulfatide antibody and interferon-gamma in myelin from glia maturation factor-deficient mice. Neurosci Res. 2007 Jun;58(2):156-63. Epub 2007 Feb 22. - Pubmed
  • Letuve S, Lajoie-Kadoch S, Audusseau S, Rothenberg ME, Fiset PO, Ludwig MS, Hamid Q: IL-17E upregulates the expression of proinflammatory cytokines in lung fibroblasts. J Allergy Clin Immunol. 2006 Mar;117(3):590-6. Epub 2006 Feb 8. - Pubmed
  • Kang JH, Lee DH, Seo HM, Park JS, Nam KH, Shin SY, Park CS, Chung IY: Regulation of Functional Phenotypes of Cord-blood-derived Eosinophils by {gamma}-secretase Inhibitor. Am J Respir Cell Mol Biol. 2007 Jun 28;. - Pubmed
DTHybrid score 1.6183

Predictions


Id Partner name Gene Name Score
4878 Glycoprotein hormones alpha chain CGA 0.0148
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0148
4850 Beta-2-glycoprotein 1 APOH 0.0148
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0148
1072 Granzyme B GZMB 0.0148
4880 Membrane cofactor protein CD46 0.0148
4189 Alpha-galactosidase A GLA 0.0148
4877 Beta-mannanase man 0.0148
4852 Reticulon-4 receptor RTN4R 0.0148
4856 CD209 antigen CD209 0.0148
442 Envelope glycoprotein gp41 0.0148
4859 Envelope glycoprotein env 0.0148
4889 Ig epsilon chain C region IGHE 0.0148
4869 Major capsid protein A430L 0.0148
757 Fusion glycoprotein F0 F 0.0148
4875 Fusion glycoprotein F0 F 0.0148
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0148
1354 Beta-glucuronidase GUSB 0.0148
3352 Structural polyprotein Not Available 0.0148
3628 Structural polyprotein Not Available 0.0148
4892 Structural polyprotein Not Available 0.0148
4845 ADAM 33 ADAM33 0.0148
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0148
4721 Beta-1,4-mannanase manA 0.0148
1184 Interferon beta IFNB1 0.0129
793 T-cell surface antigen CD2 CD2 0.0129
6858 Inactive carboxylesterase 4 CES1P1 0.0129
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0129
4861 Interleukin-6 receptor alpha chain IL6R 0.0129
1379 Interleukin-12 subunit beta IL12B 0.0129
554 Low-density lipoprotein receptor LDLR 0.0129
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0129
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0129
4890 Hemagglutinin HA 0.0129
6566 Hemagglutinin Not Available 0.0129
3444 Cyanovirin-N Not Available 0.0119
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0119
1859 Prostatic acid phosphatase ACPP 0.0119
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0119
852 Heparin cofactor 2 SERPIND1 0.0119
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0119
3140 Hemagglutinin-neuraminidase HN 0.0119
3609 Hemagglutinin-neuraminidase HN 0.0119
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0119
2297 Genome polyprotein Not Available 0.0119
2322 Genome polyprotein Not Available 0.0119
2694 Genome polyprotein Not Available 0.0119
2719 Genome polyprotein Not Available 0.0119
2860 Genome polyprotein Not Available 0.0119
2928 Genome polyprotein Not Available 0.0119
3160 Genome polyprotein Not Available 0.0119
3260 Genome polyprotein Not Available 0.0119
4783 Genome polyprotein Not Available 0.0119
5726 Genome polyprotein Not Available 0.0119
5779 Genome polyprotein Not Available 0.0119
5867 Genome polyprotein Not Available 0.0119
6253 Genome polyprotein Not Available 0.0119
6301 Genome polyprotein Not Available 0.0119
6380 Genome polyprotein Not Available 0.0119
6381 Genome polyprotein Not Available 0.0119
6437 Genome polyprotein Not Available 0.0119
6520 Genome polyprotein Not Available 0.0119
6521 Genome polyprotein Not Available 0.0119
6652 Genome polyprotein Not Available 0.0119
6734 Genome polyprotein Not Available 0.0119
6735 Genome polyprotein Not Available 0.0119
6736 Genome polyprotein Not Available 0.0119
6737 Genome polyprotein Not Available 0.0119
6738 Genome polyprotein Not Available 0.0119
6739 Genome polyprotein Not Available 0.0119
6744 Genome polyprotein Not Available 0.0119
6748 Genome polyprotein Not Available 0.0119
6894 Genome polyprotein Not Available 0.0119
6898 Genome polyprotein Not Available 0.0119
4666 Fucose-binding lectin PA-IIL lecB 0.0112
2372 Bifunctional tail protein 9 0.0112
4787 Envelope glycoprotein gp160 env 0.0112
4820 Envelope glycoprotein gp160 env 0.0112
5727 Envelope glycoprotein gp160 env 0.0112
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0107
3480 Mannan endo-1,4-beta-mannosidase manA 0.0104
64 Neuraminidase NA 0.0103
641 Neuraminidase NA 0.0103
2676 Neuraminidase NA 0.0103
3026 Neuraminidase NA 0.0103
3519 Neuraminidase NA 0.0103
6007 Neuraminidase NA 0.0103
595 Fibrinogen alpha chain FGA 0.0103
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.01
1439 Lactotransferrin LTF 0.01
1243 Cathepsin D CTSD 0.0098
2430 Chondroitinase B cslB 0.0095
958 Insulin-like growth factor 1 receptor IGF1R 0.0095
6307 Ig gamma-2 chain C region IGHG2 0.0093
309 Antithrombin-III SERPINC1 0.0093
2581 Chondroitinase AC cslA 0.0093
6847 Lactase-phlorizin hydrolase LCT 0.0093
6500 Phospholipase A2 PLA2G1B 0.009
2207 Rhodopsin RHO 0.0087
3814 Complement C1r subcomponent C1R 0.0082
4785 Ig gamma-1 chain C region IGHG1 0.0078
4604 Liver carboxylesterase 1 CES1 0.0078
76 Nitric-oxide synthase, brain NOS1 0.0077
952 Dipeptidyl peptidase 4 DPP4 0.0067
3923 Cholinesterase BCHE 0.0064
20 Prostaglandin G/H synthase 1 PTGS1 0.0059
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