Identification | |||||||
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Name | Denileukin diftitox | ||||||
Accession Number | DB00004 (BIOD00084, BTD00084) | ||||||
Type | biotech | ||||||
Description | A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system. | ||||||
Structure |
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Categories (*) | |||||||
Molecular Weight | 57647.3000 | ||||||
Groups | approved | ||||||
Monoisotopic Weight | Not Available | ||||||
Pharmacology | |||||||
Indication | For treatment of cutaneous T-cell lymphoma | ||||||
Mechanism of action | Denileukin diftitox binds to the high-affinity IL-2 receptor complex. The IL-2 receptor (Tac) subunit is expressed on activated but not resting lymphocytes. The diphtheria toxin associated with Ontak then selectively kills the IL-2 bearing cells. | ||||||
Absorption | Not Available | ||||||
Protein binding | Not Available | ||||||
Biotransformation | Not Available | ||||||
Route of elimination | Not Available | ||||||
Toxicity | Not Available | ||||||
Affected organisms |
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Interactions | |||||||
Drug Interactions |
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Food Interactions | Not Available |
Interleukin-2 receptor alpha chain | |
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Name | Interleukin-2 receptor alpha chain |
Gene Name | IL2RA |
Pharmacological action | yes |
Actions | binder |
References |
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DTHybrid score | 0.9126 |
Interleukin-2 receptor subunit beta | |
Name | Interleukin-2 receptor subunit beta |
Gene Name | IL2RB |
Pharmacological action | yes |
Actions | agonist |
References |
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DTHybrid score | 0.9124 |
Cytokine receptor common gamma chain | |
Name | Cytokine receptor common gamma chain |
Gene Name | IL2RG |
Pharmacological action | unknown |
Actions | Not Available |
References |
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DTHybrid score | 0.9067 |
Id | Partner name | Gene Name | Score |
---|---|---|---|
723 | Cytosolic phospholipase A2 | PLA2G4A | 0.1598 |
3947 | Xanthine dehydrogenase/oxidase | XDH | 0.1402 |
290 | Prostaglandin G/H synthase 2 | PTGS2 | 0.1117 |
3817 | Complement C1q subcomponent subunit C | C1QC | 0.1011 |
3816 | Complement C1q subcomponent subunit B | C1QB | 0.1011 |
3815 | Complement C1q subcomponent subunit A | C1QA | 0.101 |
6013 | Cytochrome P450 2E1 | CYP2E1 | 0.1002 |
1102 | Low affinity immunoglobulin gamma Fc region receptor III-B | FCGR3B | 0.1 |
3818 | Low affinity immunoglobulin gamma Fc region receptor III-A | FCGR3A | 0.1 |
3819 | Low affinity immunoglobulin gamma Fc region receptor II-a | FCGR2A | 0.1 |
3821 | Low affinity immunoglobulin gamma Fc region receptor II-c | FCGR2C | 0.0999 |
3814 | Complement C1r subcomponent | C1R | 0.0999 |
3820 | Low affinity immunoglobulin gamma Fc region receptor II-b | FCGR2B | 0.099 |
784 | High affinity immunoglobulin gamma Fc receptor I | FCGR1A | 0.098 |
4512 | Cytochrome P450 3A4 | CYP3A4 | 0.0748 |
2782 | Complement C1s subcomponent | C1S | 0.0535 |